دورية أكاديمية
Synapse organizers as molecular codes for synaptic plasticity.
| العنوان: | Synapse organizers as molecular codes for synaptic plasticity. |
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| المؤلفون: | Connor SA; Department of Biology, York University, Toronto, ON M3J 1P3, Canada. Electronic address: saconnor@yorku.ca., Siddiqui TJ; PrairieNeuro Research Centre, Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, MB R3E 0Z3, Canada; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada; The Children's Hospital Research Institute of Manitoba, Winnipeg, MB R3E 3P4, Canada; Program in Biomedical Engineering, University of Manitoba, Winnipeg, MB, Canada. Electronic address: tabrez.siddiqui@umanitoba.ca. |
| المصدر: | Trends in neurosciences [Trends Neurosci] 2023 Nov; Vol. 46 (11), pp. 971-985. Date of Electronic Publication: 2023 Aug 29. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Applied Science Publishing Country of Publication: England NLM ID: 7808616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-108X (Electronic) Linking ISSN: 01662236 NLM ISO Abbreviation: Trends Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Barking : Elsevier Applied Science Publishing Original Publication: Amsterdam, New York, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Synapses*/physiology , Neuronal Plasticity*/physiology, Humans ; Brain ; Cognition |
| مستخلص: | Synapse organizing proteins are multifaceted molecules that coordinate the complex processes of brain development and plasticity at the level of individual synapses. Their importance is demonstrated by the major brain disorders that emerge when their function is compromised. The mechanisms whereby the various families of organizers govern synapses are diverse, but converge on the structure, function, and plasticity of synapses. Therefore, synapse organizers regulate how synapses adapt to ongoing activity, a process central for determining the developmental trajectory of the brain and critical to all forms of cognition. Here, we explore how synapse organizers set the conditions for synaptic plasticity and the associated molecular events, which eventually link to behavioral features of neurodevelopmental and neuropsychiatric disorders. We also propose central questions on how synapse organizers influence network function through integrating nanoscale and circuit-level organization of the brain. Competing Interests: Declaration of interests The authors declare no competing interests in relation to this work. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| معلومات مُعتمدة: | PJT-463249 Canada CIHR |
| فهرسة مساهمة: | Keywords: MAM domain-containing GPI anchor; leucine-rich-repeat transmembrane neuronal proteins; long-term depression; long-term potentiation; neurexin; neurodevelopment; neuroligin; neuropsychiatric disorders; synapse organizing proteins; synaptic adhesion molecules |
| تواريخ الأحداث: | Date Created: 20230831 Date Completed: 20231023 Latest Revision: 20231027 |
| رمز التحديث: | 20231028 |
| DOI: | 10.1016/j.tins.2023.08.001 |
| PMID: | 37652840 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1878-108X |
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| DOI: | 10.1016/j.tins.2023.08.001 |