دورية أكاديمية
أعرض في EDS

Antimicrobial activity of the Lacticaseibacillus rhamnosus CRL 2244 and its impact on the phenotypic and transcriptional responses in carbapenem resistant Acinetobacter baumannii.

التفاصيل البيبلوغرافية
العنوان: Antimicrobial activity of the Lacticaseibacillus rhamnosus CRL 2244 and its impact on the phenotypic and transcriptional responses in carbapenem resistant Acinetobacter baumannii.
المؤلفون: Rodriguez C; Centro de Referencia Para Lactobacilos (CERELA), CONICET, San Miguel de Tucumán, Tucumán, Argentina., Ramlaoui D; Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton (CSUF), 800 N State College Blvd, Fullerton, CA, 92831, USA., Georgeos N; Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton (CSUF), 800 N State College Blvd, Fullerton, CA, 92831, USA., Gasca B; Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton (CSUF), 800 N State College Blvd, Fullerton, CA, 92831, USA., Leal C; Centro de Referencia Para Lactobacilos (CERELA), CONICET, San Miguel de Tucumán, Tucumán, Argentina., Subils T; Instituto de Procesos Biotecnológicos y Químicos de Rosario (IPROBYQ, CONICET-UNR), Rosario, Argentina., Tuttobene MR; Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Rosario, Argentina., Sieira R; Fundación Instituto Leloir-IIBBA CONICET, Buenos Aires, Argentina., Salzameda NT; Department of Chemistry and Biochemistry, College of Natural Science and Mathematics, CSUF, Fullerton, USA., Bonomo RA; Research Service and GRECC, Department of Veterans Affairs Medical Center, Louis Stokes Cleveland, Cleveland, OH, 44106, USA.; Departments of Medicine, Pharmacology, Molecular Biology and Microbiology, Biochemistry, Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, OH, 44106, USA., Raya R; Centro de Referencia Para Lactobacilos (CERELA), CONICET, San Miguel de Tucumán, Tucumán, Argentina., Ramirez MS; Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton (CSUF), 800 N State College Blvd, Fullerton, CA, 92831, USA. msramirez@fullerton.edu.
المصدر: Scientific reports [Sci Rep] 2023 Aug 31; Vol. 13 (1), pp. 14323. Date of Electronic Publication: 2023 Aug 31.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Acinetobacter baumannii*/genetics , Lacticaseibacillus rhamnosus* , Lactobacillales*, Lacticaseibacillus ; Anti-Bacterial Agents/pharmacology ; Cell Death ; Carbapenems/pharmacology
مستخلص: Carbapenem-resistant Acinetobacter baumannii (CRAB) is a recognized nosocomial pathogen with limited antibiotic treatment options. Lactic acid bacteria (LAB) constitute a promising therapeutic alternative. Here we studied the antibacterial properties of a collection of LAB strains using phenotypic and transcriptomic analysis against A. baumannii clinical strains. One strain, Lacticaseibacillus rhamnosus CRL 2244, demonstrated a potent inhibitory capacity on A. baumannii with a significant killing activity. Scanning electron microscopy images showed changes in the morphology of A. baumannii with an increased formation of outer membrane vesicles. Significant changes in the expression levels of a wide variety of genes were also observed. Interestingly, most of the modified genes were involved in a metabolic pathway known to be associated with the survival of A. baumannii. The paa operon, Hut system, and fatty acid degradation were some of the pathways that were induced. The analysis reveals the impact of Lcb. rhamnosus CRL 2244 on A. baumannii response, resulting in bacterial stress and subsequent cell death. These findings highlight the antibacterial properties of Lcb. rhamnosus CRL 2244 and its potential as an alternative or complementary strategy for treating infections. Further exploration and development of LAB as a treatment option could provide valuable alternatives for combating CRAB infections.
(© 2023. Springer Nature Limited.)
التعليقات: Update of: Res Sq. 2023 Jul 21;:. (PMID: 37503046)
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معلومات مُعتمدة: R01 AI100560 United States AI NIAID NIH HHS; R01 AI063517 United States AI NIAID NIH HHS; I01 BX001974 United States BX BLRD VA; SC3 GM125556 United States GM NIGMS NIH HHS; R01 AI072219 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Carbapenems)
تواريخ الأحداث: Date Created: 20230831 Date Completed: 20230904 Latest Revision: 20231123
رمز التحديث: 20231123
مُعرف محوري في PubMed: PMC10471627
DOI: 10.1038/s41598-023-41334-8
PMID: 37653052
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-023-41334-8