دورية أكاديمية
Kidney failure outcomes in children and young adults with sickle cell disease in the United States Renal Data System.
| العنوان: | Kidney failure outcomes in children and young adults with sickle cell disease in the United States Renal Data System. |
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| المؤلفون: | Zahr RS; Division of Pediatric Nephrology and Hypertension, University of Tennessee Health Science Center, Memphis, TN, USA. rzahr@uthsc.edu., Ataga KI; Center for Sickle Cell Disease, University of Tennessee Health Science Center, Memphis, TN, USA., Lebensburger JD; Division of Pediatric Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL, USA., Winer JC; Division of Academic Hospital Medicine, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA. |
| المصدر: | Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2024 Feb; Vol. 39 (2), pp. 619-623. Date of Electronic Publication: 2023 Sep 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-198X (Electronic) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Berlin : Springer International Original Publication: Berlin : Springer International, c1987- |
| مواضيع طبية MeSH: | Kidney Failure, Chronic*/epidemiology , Kidney Failure, Chronic*/etiology , Kidney Failure, Chronic*/therapy , Anemia, Sickle Cell*/complications , Anemia, Sickle Cell*/epidemiology , Anemia, Sickle Cell*/therapy, Child ; Humans ; Young Adult ; United States/epidemiology ; Renal Dialysis ; Retrospective Studies ; Kidney |
| مستخلص: | Background: Children and young adults with sickle cell disease (SCD) develop kidney disease early in childhood, with some patients progressing to require dialysis and kidney transplantation. The prevalence and outcomes of children with kidney failure (chronic kidney disease stage 5) due to SCD are not well described. This study aimed to assess the outcome of children and young adults with SCD with kidney failure compared to matched children and young adults without SCD with kidney failure in a large national database. Methods: Utilizing the United States Renal Data System (USRDS), we retrospectively examined kidney failure outcomes in children and young adults with SCD from 1998 to 2019. Results: We identified 97 patients with SCD who developed kidney failure and identified 96 matched controls with a median age of 19 years (IQR 17, 21) at the time of kidney failure diagnosis. SCD patients had significantly shorter survival (8.4 years vs. 14.0 years, p < 0.001) and had a longer waiting time for their first transplant when compared to matched non-SCD kidney failure patients (12.1 years vs. 7.3 years, p < 0.001). Conclusions: Children and young adults with SCD kidney failure have significantly higher mortality when matched to non-SCD kidney failure children and experience a longer mean time to kidney transplant. (© 2023. The Author(s), under exclusive licence to International Pediatric Nephrology Association.) |
| التعليقات: | Update of: Res Sq. 2023 May 26;:. (PMID: 37292764) |
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| معلومات مُعتمدة: | K23 HL157554 United States HL NHLBI NIH HHS; K23HL157554 United States HL NHLBI NIH HHS; K23HL157554 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: Dialysis; Outcomes; Sickle cell disease; Transplant |
| تواريخ الأحداث: | Date Created: 20230831 Date Completed: 20231219 Latest Revision: 20240202 |
| رمز التحديث: | 20240202 |
| مُعرف محوري في PubMed: | PMC10752499 |
| DOI: | 10.1007/s00467-023-06136-0 |
| PMID: | 37653351 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-198X |
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| DOI: | 10.1007/s00467-023-06136-0 |