دورية أكاديمية
PI3K Signaling Pathways as a Molecular Target for Glioblastoma Multiforme.
| العنوان: | PI3K Signaling Pathways as a Molecular Target for Glioblastoma Multiforme. |
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| المؤلفون: | da Silva ALL; Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas, AC. Simões campus, Maceió, 57072-900, Brazil.; Laboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas, AC. Simões campus, Maceió, 57072-900, Brazil., de Araújo TPG; Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas, AC. Simões campus, Maceió, 57072-900, Brazil., de Albuquerque Ferreira SC; Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas, AC. Simões campus, Maceió, 57072-900, Brazil., Leite AB; Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas, AC. Simões campus, Maceió, 57072-900, Brazil., da Silva JKS; Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas, AC. Simões campus, Maceió, 57072-900, Brazil., Albuquerque LWN; Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas, AC. Simões campus, Maceió, 57072-900, Brazil., de Lima ARV; Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas, AC. Simões campus, Maceió, 57072-900, Brazil., Barros HCS; Municipal Secretary of Health of Maceio, Governo do estado de Alagoas, Brazil., Silva LR; Biological and Molecular Chemistry Research Group, Institute of Chemistry and Biotechnology, Federal University of Alagoas, AC. Simões campus, Maceió, 57072-900, Brazil., da Silva-Júnior EF; Biological and Molecular Chemistry Research Group, Institute of Chemistry and Biotechnology, Federal University of Alagoas, AC. Simões campus, Maceió, 57072-900, Brazil.; Laboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas, AC. Simões campus, Maceió, 57072-900, Brazil., de Araújo-Júnior JX; Laboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas, AC. Simões campus, Maceió, 57072-900, Brazil., Neto VM; Paulo Niemeyer State Brain Institute, Study and Research Center, Brain Biomedicine Laboratory, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., de Queiroz AC; Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas, AC. Simões campus, Maceió, 57072-900, Brazil., Alexandre-Moreira MS; Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas, AC. Simões campus, Maceió, 57072-900, Brazil. |
| المصدر: | Current protein & peptide science [Curr Protein Pept Sci] 2024; Vol. 25 (1), pp. 12-26. |
| نوع المنشور: | Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 100960529 Publication Model: Print Cited Medium: Internet ISSN: 1875-5550 (Electronic) Linking ISSN: 13892037 NLM ISO Abbreviation: Curr Protein Pept Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers Original Publication: Hilversum, Netherlands ; Boca Raton, FL : Bentham Science Publishers, c2000- |
| مواضيع طبية MeSH: | Glioblastoma*/drug therapy , Glioblastoma*/genetics , Glioblastoma*/metabolism , Brain Neoplasms*/drug therapy , Brain Neoplasms*/genetics , Brain Neoplasms*/pathology, Humans ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction |
| مستخلص: | Glioblastoma multiforme (GBM) is the most common type of cancer that affects the central nervous system (CNS). It currently accounts for about 2% of diagnosed malignant tumors worldwide, with 296,000 new cases reported per year. The first-choice treatment consists of surgical resection, radiotherapy, and adjuvant chemotherapy, which increases patients' survival by 15 months. New clinical and pre-clinical research aims to improve this prognosis by proposing the search for new drugs that effectively eliminate cancer cells, circumventing problems such as resistance to treatment. One of the promising therapeutic strategies in the treatment of GBM is the inhibition of the phosphatidylinositol 3-kinase (PI3K) pathway, which is closely related to the process of tumor carcinogenesis. This review sought to address the main scientific studies of synthetic or natural drug prototypes that target specific therapy co-directed via the PI3K pathway, against human glioblastoma. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: Glioblastoma; cancer; oncology.; pharmacology; phosphatidylinositol 3-kinase (PI3K); therapy |
| المشرفين على المادة: | EC 2.7.1.- (Phosphatidylinositol 3-Kinases) |
| تواريخ الأحداث: | Date Created: 20230901 Date Completed: 20240201 Latest Revision: 20240201 |
| رمز التحديث: | 20240201 |
| DOI: | 10.2174/1389203724666230830125102 |
| PMID: | 37653631 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-5550 |
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| DOI: | 10.2174/1389203724666230830125102 |