دورية أكاديمية
Gut Microbiota and Cognitive Function Among Women Living with HIV.
| العنوان: | Gut Microbiota and Cognitive Function Among Women Living with HIV. |
|---|---|
| المؤلفون: | Hua S; Department of Population Health, Division of Epidemiology, New York University Grossman School of Medicine, New York, NY, USA.; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Peters BA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Lee S; Department of Anesthesiology, Nuvance Health, Norwalk Hospital, Norwalk, CT, USA., Fitzgerald K; Johns Hopkins University School of Medicine, Baltimore, MD, USA., Wang Z; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Sollecito CC; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA., Grassi E; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA., Wiek F; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA., St Peter L; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA., D'Souza G; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Weber KM; Hektoen Institute of Medicine/Cook County Health, Chicago, IL, USA., Kaplan RC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Gustafson D; Department of Neurology, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA., Sharma A; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA., Burk RD; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA., Rubin LH; Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Qi Q; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. |
| المصدر: | Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2023; Vol. 95 (3), pp. 1147-1161. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; Washington : IOS Press, c1998- |
| مواضيع طبية MeSH: | HIV Infections*/complications , Gastrointestinal Microbiome*/genetics , Alzheimer Disease*/complications , Cognitive Dysfunction*/genetics, Humans ; Female ; Cross-Sectional Studies ; Cognition |
| مستخلص: | Background: Altered gut microbiota has been associated with cognitive dysfunction and Alzheimer's disease, but little is known among people living with HIV. Objective: To examine associations between gut microbiota and cognitive impairment among women with or without HIV. Methods: This is a cross-sectional study of 446 women (302 HIV+) who had completed a neuropsychological test battery and stool sample collected within 1 year. Gut microbiota composition was quantified using 16SV4 rRNA gene sequencing and microbial functional pathways were predicted using PICRUSt. Cognitive domains included attention, executive function, learning, memory, fluency, processing speed, and motor function. Cognitive impairment was defined as two or more domains with T scores < 1 SD below mean. ANCOM-II was used to identify taxa and functional pathways associated with cognitive impairment, and the associations were further examined by multivariable logistic regression. Results: In overall sample, adjusting for multiple covariates including HIV status, we found that higher abundance of Methanobrevibacter, Odoribacter, Pyramidobacter, Eubacterium, Ruminococcus, and Gemmiger, and lower abundance of Veillonella were associated with cognitive impairment. The associations between these taxa and cognitive impairment were more profound in HIV+ women compared to HIV- women. Most associations with bacterial taxa were observed for learning and memory. We found accompanying microbial functional differences associated with cognitive impairment, including twelve enriched pathways and three depleted pathways. Conclusions: In women with or without HIV infection, this study identified multiple altered gut bacterial taxa and functional pathways associated with cognitive impairment, supporting the potential role of gut microbiota in cognitive dysfunction and Alzheimer's disease. |
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| معلومات مُعتمدة: | U01 AI035004 United States AI NIAID NIH HHS; U01 HL146208 United States HL NHLBI NIH HHS; K01 HL160146 United States HL NHLBI NIH HHS; R01 HL126543 United States HL NHLBI NIH HHS; U01 HL146192 United States HL NHLBI NIH HHS; U01 HL146242 United States HL NHLBI NIH HHS; P30 AI124414 United States AI NIAID NIH HHS; U01 HL146194 United States HL NHLBI NIH HHS; U01 HL146241 United States HL NHLBI NIH HHS; P30 AI027767 United States AI NIAID NIH HHS; P30 AI050409 United States AI NIAID NIH HHS; U01 HL146333 United States HL NHLBI NIH HHS; U01 HL146245 United States HL NHLBI NIH HHS; R01 MD011389 United States MD NIMHD NIH HHS; U01 HL146205 United States HL NHLBI NIH HHS; R01 HL095140 United States HL NHLBI NIH HHS; P30 MH116867 United States MH NIMH NIH HHS; R01 HL083760 United States HL NHLBI NIH HHS; R01 HL132794 United States HL NHLBI NIH HHS; K01 HL129892 United States HL NHLBI NIH HHS; R01 HL170904 United States HL NHLBI NIH HHS; P30 AI073961 United States AI NIAID NIH HHS; U01 HL146201 United States HL NHLBI NIH HHS; U01 HL146193 United States HL NHLBI NIH HHS; R01 HL140976 United States HL NHLBI NIH HHS; U01 HL146204 United States HL NHLBI NIH HHS; U01 HL146202 United States HL NHLBI NIH HHS; UL1 TR001881 United States TR NCATS NIH HHS; P30 CA013330 United States CA NCI NIH HHS; UL1 TR000004 United States TR NCATS NIH HHS; U01 HL146240 United States HL NHLBI NIH HHS; U01 HL146203 United States HL NHLBI NIH HHS; K01 HL137557 United States HL NHLBI NIH HHS; UL1 TR003098 United States TR NCATS NIH HHS; P30 AI050410 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: Alzheimer’s disease; HIV; cognitive impairment; gut microbiome; human; women |
| تواريخ الأحداث: | Date Created: 20230904 Date Completed: 20231003 Latest Revision: 20240617 |
| رمز التحديث: | 20240617 |
| مُعرف محوري في PubMed: | PMC10771810 |
| DOI: | 10.3233/JAD-230117 |
| PMID: | 37661881 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-8908 |
|---|---|
| DOI: | 10.3233/JAD-230117 |