دورية أكاديمية

A novel inclusion complex of oxybenzone with C -methylresorcin[4]arene deters skin permeation.

التفاصيل البيبلوغرافية
العنوان: A novel inclusion complex of oxybenzone with C -methylresorcin[4]arene deters skin permeation.
المؤلفون: Kang X; James L. Winkle College of Pharmacy, University of Cincinnati 231 Albert Sabin Way, MSB 3109 C Cincinnati OH USA kumariha@ucmail.uc.edu., Eisenhart A; Department of Chemistry, College of Arts and Science, University of Cincinnati 155 B McMicken Hall Cincinnati OH 45221 USA., Dar AA; James L. Winkle College of Pharmacy, University of Cincinnati 231 Albert Sabin Way, MSB 3109 C Cincinnati OH USA kumariha@ucmail.uc.edu., Mittapalli RR; James L. Winkle College of Pharmacy, University of Cincinnati 231 Albert Sabin Way, MSB 3109 C Cincinnati OH USA kumariha@ucmail.uc.edu., Greenwood A; Department of Chemistry, College of Arts and Science, University of Cincinnati 155 B McMicken Hall Cincinnati OH 45221 USA., Alsheddi L; James L. Winkle College of Pharmacy, University of Cincinnati 231 Albert Sabin Way, MSB 3109 C Cincinnati OH USA kumariha@ucmail.uc.edu., Beck TL; Department of Chemistry, College of Arts and Science, University of Cincinnati 155 B McMicken Hall Cincinnati OH 45221 USA., Li SK; James L. Winkle College of Pharmacy, University of Cincinnati 231 Albert Sabin Way, MSB 3109 C Cincinnati OH USA kumariha@ucmail.uc.edu., Kumari H; James L. Winkle College of Pharmacy, University of Cincinnati 231 Albert Sabin Way, MSB 3109 C Cincinnati OH USA kumariha@ucmail.uc.edu.
المصدر: RSC advances [RSC Adv] 2023 Aug 31; Vol. 13 (37), pp. 25846-25852. Date of Electronic Publication: 2023 Aug 31 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Cambridge [England] : Royal Society of Chemistry, [2011]-
مستخلص: Oxybenzone (OXB), a very widely used sunscreen ingredient has the potential to block both UVA and UVB but can penetrate through skin. Studies have revealed its presence in the blood and urine of most humans, which may lead to long-term health effects. As the confined cavities of macrocycles can alter the physical and chemical properties of encapsulated guests, in this study, we investigated the formation of host-guest complexes between C -methylresorcin[4]arene and OXB. Combined experimental (NMR spectroscopy, UV/vis absorption, and fluorescence spectroscopy) and theoretical investigation confirmed the formation of a weak host-guest complex that had a 1 : 1 stoichiometry. Furthermore, skin permeation testing revealed that complexation by C -methylresorcin[4]arene significantly reduced the skin permeation of OXB which can potentially limit the harmful effects of this organic sunscreen.
Competing Interests: There are no conflicts to declare.
(This journal is © The Royal Society of Chemistry.)
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تواريخ الأحداث: Date Created: 20230904 Latest Revision: 20230905
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10468953
DOI: 10.1039/d3ra01890c
PMID: 37664192
قاعدة البيانات: MEDLINE
الوصف
تدمد:2046-2069
DOI:10.1039/d3ra01890c