دورية أكاديمية
Heartache in a Bottle: Understanding Alcoholic Cardiomyopathy.
| العنوان: | Heartache in a Bottle: Understanding Alcoholic Cardiomyopathy. |
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| المؤلفون: | Ihekire NL; Internal Medicine, Windsor University School of Medicine, Cayon, KNA., Okobi OE; Family Medicine, Medficient Health Systems, Laurel, USA.; Family Medicine, Lakeside Medical Center, Belle Glade, USA., Adedoye EA; Internal Medicine, Mater Dei Hospital, Msida, MLT., Akahara PF; Family Medicine, Inglewood Medical Centre, Edmonton, CAN., Onyekwere AO; School of Medicine, Richmond Gabriel University, Kingstown, VCT., Afrifa-Yamoah J; Internal Medicine, Korle Bu Teaching Hospital, Accra, GHA., Akinyemi FB; Internal Medicine, Windsor University School of Medicine, Cayon, KNA. |
| المصدر: | Cureus [Cureus] 2023 Aug 03; Vol. 15 (8), pp. e42886. Date of Electronic Publication: 2023 Aug 03 (Print Publication: 2023). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Palo Alto, CA : Cureus, Inc. |
| مستخلص: | Alcoholic cardiomyopathy (ACM) is a cardiac ailment marked by impaired contraction and dilation of one or both ventricles of the heart. The extent of daily alcohol intake and duration of alcohol abuse are linked to the development of ACM, although the exact thresholds and timeline for alcohol misuse to induce heart dysfunction remain uncertain. Thus, the objective of this systematic review is to comprehensively evaluate the existing knowledge on the specific disease entity, particularly in light of the ongoing issue of alcohol misuse, with the intention of determining if recent advancements and discoveries have significantly altered the understanding of this condition compared to the past century. This systematic review involved a literature search that was conducted on PubMed to identify suitable and appropriate literature for the study. The inclusion criteria encompassed articles that focused on ACM or the relationship between alcohol abuse and cardiac dysfunction, involved human subjects or relevant animal models, were written in the English language, and were published within the last 10 years. The exclusion criteria included duplicates, case reports, letters, editorials, and reviews not specifically addressing ACM. As a result, a total of 18 articles were included in this systematic review. The risk of bias was assessed through the use of the Cochrane risk-of-bias tool for clinical trials. The findings of this systematic review indicated that the likelihood of ACM occurrence significantly rose when the consumption of over 80 g of alcohol per day occurred for at least five years. The systematic review further revealed that ACM is associated with various detrimental changes in the cellular, structural, and histological aspects of the heart muscles, even though the specific clinical and histological characteristics of ACM have yet to be established. In individuals with an extensive history of excessive alcohol abuse, the diagnosis of ACM was reached through the exclusion of other potential causes of the condition. The fundamental approach to treatment lies in abstaining from alcohol. It is crucial to manage symptoms in individuals with secondary heart failure and address any related complications. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Ihekire et al.) |
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| فهرسة مساهمة: | Keywords: alcohol; alcohol-induced cardiomyopathy; alcoholic cardiomyopathy (acm); alcoholic heart disease; dilated cardiomyopathy (dcm) |
| تواريخ الأحداث: | Date Created: 20230904 Latest Revision: 20230905 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC10474910 |
| DOI: | 10.7759/cureus.42886 |
| PMID: | 37664402 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2168-8184 |
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| DOI: | 10.7759/cureus.42886 |