دورية أكاديمية
TLR4/ MyD88/NF-κB signaling pathway involved in the protective effect of diacerein against lung fibrosis in rats.
| العنوان: | TLR4/ MyD88/NF-κB signaling pathway involved in the protective effect of diacerein against lung fibrosis in rats. |
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| المؤلفون: | Abdel-Aziz AM; Department of Pharmacology, Faculty of Medicine, Minia University, Minia, Egypt., Fathy EM; Department of Pharmacology, Faculty of Medicine, Minia University, Minia, Egypt., Hafez HM; Department of Pharmacology, Faculty of Medicine, Minia University, Minia, Egypt., Ahmed AF; Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minia, Egypt.; Department of Histology and Cell Biology, Misr University for Science and Technology, 6th of October City, Egypt., Mohamed MZ; Department of Pharmacology, Faculty of Medicine, Minia University, Minia, Egypt. |
| المصدر: | Human & experimental toxicology [Hum Exp Toxicol] 2023 Jan-Dec; Vol. 42, pp. 9603271231200213. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publications Country of Publication: England NLM ID: 9004560 Publication Model: Print Cited Medium: Internet ISSN: 1477-0903 (Electronic) Linking ISSN: 09603271 NLM ISO Abbreviation: Hum Exp Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : SAGE Publications Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical Division, Macmillan Press, c1990- |
| مواضيع طبية MeSH: | NF-kappa B*/metabolism , Pulmonary Fibrosis*/chemically induced , Pulmonary Fibrosis*/drug therapy , Pulmonary Fibrosis*/prevention & control, Rats ; Male ; Animals ; Myeloid Differentiation Factor 88/metabolism ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Toll-Like Receptor 4/metabolism ; Signal Transduction ; Transforming Growth Factor beta/metabolism ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use |
| مستخلص: | Purpose: Pulmonary fibrosis (PF) is an inescapable problem. Diacerein, a chondro-protective drug, has antioxidant and anti-inflammatory effects. Its effect on PF injury has not yet been fully clarified. Therefore, the current study aimed to detect its protective effect on lung tissue with the explanation of possible underlying mechanisms. Methods: Adult male albino rats were assigned to four groups: control group, diacerein control group, PF non-treated group, and PF diacerein pretreated group. Lung tissue oxidative stress parameters, inflammatory biomarkers mainly Toll-like receptors-4 (TLR4), and myeloid differentiation factor 88 (MyD88) levels were determined. Histopathological examination of lung tissue and immunohistochemical studies of nuclear factor-kappa B (NF-κB), and transforming growth factor- β (TGF-β) were also done. Results: Diacerein pretreatment has the ability to restore the PF damaging effect, proved by the reduction of the oxidative stress and lung tissue inflammation via downregulation of TLR4/NF-κB signaling pathway together with the restoration of TGF-β level and improvement of the histopathological and immunohistochemical study findings in the lung tissue. Conclusion: These results suggested the protective effect of diacerein on PF relies on its antioxidant and anti-inflammatory effects reducing TLR4/NF-κB signaling pathway. |
| فهرسة مساهمة: | Keywords: Diacerein; inflammatory pathway; oxidative stress; pulmonary fibrosis |
| المشرفين على المادة: | 0 (NF-kappa B) 0 (Myeloid Differentiation Factor 88) 0 (Antioxidants) 0 (Toll-Like Receptor 4) 0 (Transforming Growth Factor beta) 0 (Anti-Inflammatory Agents) |
| تواريخ الأحداث: | Date Created: 20230904 Date Completed: 20231102 Latest Revision: 20231102 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1177/09603271231200213 |
| PMID: | 37664986 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1477-0903 |
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| DOI: | 10.1177/09603271231200213 |