دورية أكاديمية
Multidrug resistant and multivirulent avian bacterial pathogens: tackling experimental leg disorders using phytobiotics and antibiotics alone or in combination.
| العنوان: | Multidrug resistant and multivirulent avian bacterial pathogens: tackling experimental leg disorders using phytobiotics and antibiotics alone or in combination. |
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| المؤلفون: | Awad NFS; Department of Avian and Rabbit Medicine, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt., Abd El-Hamid MI; Department of Microbiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt. Electronic address: mero_micro2006@yahoo.com., Nabil NM; Reference Laboratory for Veterinary Quality Control on Poultry Production (RLQP), Animal Health Research Institute (AHRI), Agriculture Research Center (ARC), Dokki, Giza 12618, Egypt., Tawakol MM; Reference Laboratory for Veterinary Quality Control on Poultry Production (RLQP), Animal Health Research Institute (AHRI), Agriculture Research Center (ARC), Dokki, Giza 12618, Egypt., Eid S; Department of Bacteriology, Reference Laboratory for Veterinary Quality Control on Poultry Production (RLQP), Animal Health Research Institute (AHRI), Agriculture Research Center (ARC), Dokki, Giza 12618, Egypt., Al-Zaban MI; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Farouk H; Reference Laboratory for Veterinary Quality Control on Poultry Production (RLQP), Animal Health Research Institute (AHRI), Agriculture Research Center (ARC), Dokki, Giza 12618, Egypt., Zakai SA; Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Elkelish A; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia; Department of Botany, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt., Ibrahim MS; Department of Poultry Diseases, Animal Health Research Institute (AHRI), Mansoura Laboratory, Agriculture Research Center (ARC), Mansoura, Egypt., Mahmoud HA; Department of Bacteriology, Animal Health Research Institute (AHRI), Mansoura Laboratory, Agriculture Research Center (ARC), Mansoura, Egypt., Salem SM; Department of Pathology, Animal Health Research Institute (AHRI), Zagazig Branch, Agriculture Research Center (ARC), Zagazig 44516, Egypt., Ismail HM; Department of Pathology, Animal Health Research Institute (AHRI), Mansoura Laboratory, Agriculture Research Center (ARC), Mansoura, Egypt., Hamed RI; Department of Poultry Diseases, Reference Laboratory for Quality Control on Poultry Production (RLQP), Animal Health Research Institute (AHRI), Zagazig Branch, Agriculture Research Center (ARC), Zagazig 44516, Egypt. |
| المصدر: | Poultry science [Poult Sci] 2023 Nov; Vol. 102 (11), pp. 102889. Date of Electronic Publication: 2023 Jun 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 0401150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-3171 (Electronic) Linking ISSN: 00325791 NLM ISO Abbreviation: Poult Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : [Cambridge, UK] : Elsevier Original Publication: Champaign Il : Poultry Science Association |
| مواضيع طبية MeSH: | Methicillin-Resistant Staphylococcus aureus* , Anti-Infective Agents*/pharmacology , Staphylococcal Infections*/veterinary, Animals ; Anti-Bacterial Agents/pharmacology ; Chickens/microbiology ; Escherichia coli ; Staphylococcus aureus ; Poultry ; Salmonella ; Ducks/microbiology ; Clavulanic Acid/pharmacology ; Amoxicillin/pharmacology ; Microbial Sensitivity Tests/veterinary |
| مستخلص: | Locomotor disorders caused by multidrug-resistant (MDR) bacterial pathogens denote one of the most detrimental issues that collectively threaten the poultry industry leading to pronounced economic losses across the world. Hence, searching for effective alternatives, especially those extracted from plant origins became of great priority targeting a partial or complete replacement of chemical antimicrobials to tackle their developing resistance. Therefore, we aimed to determine the prevalence and antimicrobial resistance of Staphylococcus aureus (S. aureus), Salmonella species, Mycoplasma synoviae (M. synoviae), and Escherichia coli (E. coli) recovered from 500 broilers and ducks (250 each) with locomotor disorders in various farms in Dakahlia and Sharkia Governorates, Egypt. Additionally, we assessed, for the first time, the in vitro antimicrobial effectiveness of marjoram, garlic, ginger and cinnamon essential oils (EOs) against MDR and multivirulent bacterial isolates as well as the in vivo efficiency of the most effective antibiotics and EOs either separately or in combination in the treatment of experimentally induced poultry leg disorders. The overall prevalence rates of S. aureus, E. coli, Salmonella species, and M. synoviae were 54, 48, 36, and 2%, respectively. Salmonella species and S. aureus prevailed among ducks and broilers (36 and 76%, respectively). Notably, MDR was observed in 100, 91.7, 81.1, and 78.5% of M. synoviae, E. coli, Salmonella, and S. aureus isolates, respectively. Our in vitro results displayed that marjoram was the most forceful EO against MDR and multivirulent chicken vancomycin-resistant S. aureus (VRSA) and duck S. Typhimurium isolates. The current in vivo results declared that marjoram in combination with florfenicol or amoxicillin/clavulanic acid succeeded in relieving the induced duck and chicken leg disorders caused by S. Typhimurium and VRSA, respectively. This was evidenced by improvement in the clinical and histopathological pictures with a reduction of bacterial loads in the experimental birds. Our encountered successful in vitro and in vivo synergistic effectiveness of marjoram combined with florfenicol or amoxicillin/clavulanic acid recommends their therapeutic application for leg disorders and offers opportunities for reducing the antibiotics usage in the poultry industry. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: S. aureus; Salmonella; leg disorder; marjoram; poultry |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 9J97307Y1H (florfenicol) 0 (Anti-Infective Agents) 23521W1S24 (Clavulanic Acid) 804826J2HU (Amoxicillin) |
| تواريخ الأحداث: | Date Created: 20230904 Date Completed: 20231023 Latest Revision: 20231023 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10491818 |
| DOI: | 10.1016/j.psj.2023.102889 |
| PMID: | 37666144 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1525-3171 |
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| DOI: | 10.1016/j.psj.2023.102889 |