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Anatomical characterisation of three different psychosurgical targets in the subthalamic area: from the basal ganglia to the limbic system.

التفاصيل البيبلوغرافية
العنوان: Anatomical characterisation of three different psychosurgical targets in the subthalamic area: from the basal ganglia to the limbic system.
المؤلفون: Santin MDN; Sorbonne Université, Institut du Cerveau-Paris Brain Institute- ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, 75013, Paris, France., Tempier N; Sorbonne Université, Institut du Cerveau-Paris Brain Institute- ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, 75013, Paris, France., Belaid H; Service de Neurochirurgie, Hôpital Fondation Adolphe de Rothschild, 29 rue Manin, Paris, France., Zenoni M; Sorbonne Université, Institut du Cerveau-Paris Brain Institute- ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, 75013, Paris, France., Dumas S; Oramacell, Paris, France., Wallén-Mackenzie Å; Department of Organismal Biology, Unit of Comparative Physiology, Uppsala University, S-756 32, Uppsala, Sweden., Bardinet E; Sorbonne Université, Institut du Cerveau-Paris Brain Institute- ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, 75013, Paris, France., Destrieux C; UMR Inserm U1253, IBrain, Université de Tours, Tours, France.; Laboratoire d'Anatomie, Faculté de Médecine, Université François Rabelais, Tours, France., François C; Sorbonne Université, Institut du Cerveau-Paris Brain Institute- ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, 75013, Paris, France., Karachi C; Sorbonne Université, Institut du Cerveau-Paris Brain Institute- ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, 75013, Paris, France. carine.karachi@gmail.com.; AP-HP, Hôpital de la Pitié-Salpêtrière, Service de Neurochirurgie, Paris, France. carine.karachi@gmail.com.
المصدر: Brain structure & function [Brain Struct Funct] 2023 Nov; Vol. 228 (8), pp. 1977-1992. Date of Electronic Publication: 2023 Sep 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101282001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1863-2661 (Electronic) Linking ISSN: 18632653 NLM ISO Abbreviation: Brain Struct Funct Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer-Verlag, c2007-
مواضيع طبية MeSH: Limbic System* , Basal Ganglia*, Humans ; Animals ; Brain ; Medial Forebrain Bundle ; Dopamine ; Macaca
مستخلص: Effective neural stimulation for the treatment of severe psychiatric disorders needs accurate characterisation of surgical targets. This is especially true for the medial subthalamic region (MSR) which contains three targets: the anteromedial STN for obsessive compulsive disorder (OCD), the medial forebrain bundle (MFB) for depression and OCD, and the "Sano triangle" for pathological aggressiveness. Blocks containing the subthalamic area were obtained from two human brains. After obtaining 11.7-Tesla MRI, blocks were cut in regular sections for immunohistochemistry. Fluorescent in situ hybridisation was performed on the macaque MSR. Electron microscopic observation for synaptic specialisation was performed on human and macaque subthalamic fresh samples. Images of human brain sections were reconstructed in a cryoblock which was registered on the MRI and histological slices were then registered. The STN contains glutamatergic and fewer GABAergic neurons and has no strict boundary with the adjacent MSR. The anteromedial STN has abundant dopaminergic and serotoninergic innervation with very sparse dopaminergic neurons. The MFB is composed of dense anterior dopaminergic and posterior serotoninergic fibres, and fewer cholinergic and glutamatergic fibres. Medially, the Sano triangle presumably contains orexinergic terminals from the hypothalamus, and neurons with strong nuclear oestrogen receptor-alpha staining with a decreased anteroposterior and mediolateral gradient of staining. These findings provide new insight regarding MSR cells and their fibre specialisation, forming a transition zone between the basal ganglia and the limbic systems. Our 3D reconstruction enabled us to visualize the main histological features of the three targets which should enable better targeting and understanding of neuromodulatory stimulation results in severe psychiatric conditions.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Deep brain stimulation; Immunohistochemistry; Medial forebrain bundle; Psychiatric disease; Sano triangle; Subthalamic nucleus
المشرفين على المادة: VTD58H1Z2X (Dopamine)
تواريخ الأحداث: Date Created: 20230905 Date Completed: 20230925 Latest Revision: 20230925
رمز التحديث: 20240514
DOI: 10.1007/s00429-023-02691-2
PMID: 37668733
قاعدة البيانات: MEDLINE
الوصف
تدمد:1863-2661
DOI:10.1007/s00429-023-02691-2