دورية أكاديمية
Unintended Consequences: Risk of Opportunistic Infections Associated With Long-term Glucocorticoid Therapies in Adults.
| العنوان: | Unintended Consequences: Risk of Opportunistic Infections Associated With Long-term Glucocorticoid Therapies in Adults. |
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| المؤلفون: | Chastain DB; Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Albany, Georgia, USA., Spradlin M; Division of Medical Oncology, University of Colorado School of Medicine, Aurora, Colorado, USA., Ahmad H; Division of Medical Oncology, University of Colorado School of Medicine, Aurora, Colorado, USA., Henao-Martínez AF; Division of Infectious Diseases, University of Colorado, Aurora, Colorado, USA. |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2024 Apr 10; Vol. 78 (4), pp. e37-e56. |
| نوع المنشور: | Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | Glucocorticoids*/adverse effects , Opportunistic Infections*/epidemiology , Opportunistic Infections*/etiology, Adult ; Humans ; Immunosuppressive Agents/adverse effects ; Anti-Inflammatory Agents |
| مستخلص: | Glucocorticoids are widespread anti-inflammatory medications used in medical practice. The immunosuppressive effects of systemic glucocorticoids and increased susceptibility to infections are widely appreciated. However, the dose-dependent model frequently used may not accurately predict the risk of infection in all patients treated with long-term glucocorticoids. In this review, we examine the risks of opportunistic infections (OIs) in patients requiring glucocorticoid therapy by evaluating the influence of the glucocorticoid dose, duration, and potency, combined with biological and host clinical factors and concomitant immunosuppressive therapy. We propose strategies to prevent OIs, which involve screening, antimicrobial prophylaxis, and immunizations. While this review focuses on patients with autoimmune, inflammatory, or neoplastic diseases, the potential risks and preventative strategies are likely applicable to other populations. Clinicians should actively assess the benefit-harm ratios of systemic glucocorticoids and implement preventive efforts to decrease their associated infections complications. Competing Interests: Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: Pneumocystis carinii; glucocorticoids; immune system diseases; infections; opportunistic infections |
| المشرفين على المادة: | 0 (Glucocorticoids) 0 (Immunosuppressive Agents) 0 (Anti-Inflammatory Agents) |
| تواريخ الأحداث: | Date Created: 20230905 Date Completed: 20240412 Latest Revision: 20240412 |
| رمز التحديث: | 20240412 |
| DOI: | 10.1093/cid/ciad474 |
| PMID: | 37669916 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
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| DOI: | 10.1093/cid/ciad474 |