دورية أكاديمية
Response and local control in patients treated with low-dose radiotherapy for tumoral mycosis fungoides.
| العنوان: | Response and local control in patients treated with low-dose radiotherapy for tumoral mycosis fungoides. |
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| المؤلفون: | Pena J; Center for Dermatology Research, Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Cull D; Center for Dermatology Research, Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Strowd LC; Center for Dermatology Research, Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Vaidya R; Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC, USA., Seegars MB; Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, USA., Ahn C; Center for Dermatology Research, Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.; Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Winkfield KM; Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, USA., Hughes RT; Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC, USA. |
| المصدر: | Leukemia & lymphoma [Leuk Lymphoma] 2023 Dec; Vol. 64 (13), pp. 2202-2207. Date of Electronic Publication: 2023 Sep 06. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 9007422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2403 (Electronic) Linking ISSN: 10268022 NLM ISO Abbreviation: Leuk Lymphoma Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [Philadelphia, PA] : Taylor & Francis Original Publication: Chur ; New York : London, UK : Harwood Academic Publishers ; Distributed by STBS, 1989- |
| مواضيع طبية MeSH: | Skin Neoplasms*/radiotherapy , Skin Neoplasms*/pathology , Mycosis Fungoides*/diagnosis , Mycosis Fungoides*/radiotherapy , Mycosis Fungoides*/pathology, Humans ; Treatment Outcome |
| مستخلص: | Low-dose radiotherapy (LDRT), defined in this study as 2 fractions of 4 Gy delivered on consecutive days, is an effective option for local palliation of mycosis fungoides (MF), but its efficacy for tumoral lesions (TL) needs investigation. We assessed response and local control (LC) rates for patients treated with LDRT for MF and compared these outcomes between TL and non-TL. A total of 73 lesions in 18 patients treated with LDRT between 2013-2020 were analyzed. Response was defined as complete response (CR), partial response (PR), or no response (NR). In the non-TL versus TL groups, CR was observed in 16.7% v. 4.0%, PR in 81.2% v. 80.0%, NR in 2.1% v. 16.0%, respectively. 2-year LC was 100% for non-TL and 61% for TLs ( p < 0.01). LDRT yields excellent response and lesion control for non-TLs and is associated with lower response rates and LC for TLs. |
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| معلومات مُعتمدة: | UL1 TR001420 United States TR NCATS NIH HHS |
| فهرسة مساهمة: | Keywords: Cutaneous t-cell lymphoma; dermatopathology; oncology; radiation therapy; tumor Local Abstract: [plain-language-summary] Low-dose radiation therapy yields excellent response and lesion control for non-tumoral lesions. |
| تواريخ الأحداث: | Date Created: 20230906 Date Completed: 20231225 Latest Revision: 20240730 |
| رمز التحديث: | 20240730 |
| مُعرف محوري في PubMed: | PMC10873100 |
| DOI: | 10.1080/10428194.2023.2254435 |
| PMID: | 37671707 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1029-2403 |
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| DOI: | 10.1080/10428194.2023.2254435 |