دورية أكاديمية
Delays in treatment initiation and conclusion in women with stage IA to IIIB cervical cancer: A survival study in a hospital-based cohort from a developing country.
| العنوان: | Delays in treatment initiation and conclusion in women with stage IA to IIIB cervical cancer: A survival study in a hospital-based cohort from a developing country. |
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| المؤلفون: | da Silva IF; Department of Epidemiology and Quantitative Methods in Health, National School of public Health, Oswaldo Cruz Foundation, Brazil; Graduate Program of Environmental Public Health, Nation al School of public Health, Oswaldo Cruz Foundation, Brazil. Electronic address: ilceferreira@yahoo.com.br., da Silva IF; Graduate Program of Environmental Public Health, Nation al School of public Health, Oswaldo Cruz Foundation, Brazil., Saraceni V; Superintendence of Health Surveillance, Municipal Health Secretariat of Rio de Janeiro, Rio de Janeiro, Brazil., Koifman RJ; Department of Epidemiology and Quantitative Methods in Health, National School of public Health, Oswaldo Cruz Foundation, Brazil; Graduate Program of Environmental Public Health, Nation al School of public Health, Oswaldo Cruz Foundation, Brazil. |
| المصدر: | Cancer epidemiology [Cancer Epidemiol] 2023 Oct; Vol. 86, pp. 102450. Date of Electronic Publication: 2023 Sep 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101508793 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-783X (Electronic) Linking ISSN: 18777821 NLM ISO Abbreviation: Cancer Epidemiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier |
| مستخلص: | Aim: To evaluate the effect of delays in stage IA to IIIB cervical cancer treatment initiation and conclusion on hospital-based survival among Brazilian women. Methods: A retrospective follow-up study was conducted in a stage IA to IIIB cervical cancer cohort treated from 2012 and 2014 and followed until December 31, 2017 in Rio de Janeiro. Delay in treatment initiation definition was defined based on the Brazilian law of 60 days for treatment initiation after diagnosis. Delay in treatment conclusion was defined based on the literature and sample distributions: < 120/121-200/> 200 days. The endpoint was death(from all causes or cervical cancer). Death causes and dates were obtained by a record linkage procedure between the hospital cancer registry and the Mortality Information System. Global 36-month survival and HRs were estimated by the KaplanMeier method and proportional Cox regression models, respectively. Results: From 865 patients, 269(31.1%) died over the median follow-up time of 27 months. Delay on treatment initiation(>60-days) was 92.8%, while the delay in treatment conclusion(>120 days) was 87.5%. Overall survival was 61.3% (<60-days:62.6%; 61-90 days:63.5%). Among stage IIB-IIIB, women treated < 60-days presented 40.1% survival, while 61-90-days had 52.5%, and > 90-days had 53.3%. Delays in treatment conclusion significantly reduced survival[72.2%(<120-days) to 60.7%(>200-days)]. Multivariate analysis showed that delays in treatment initiation did not affect 36-month death risk. Compared to women concluding treatment in < 120-days, those taking 121-200-days or > 200-days showed increases in death risk of 89%(95%CI:1.10-3.24) and 111%(95%CI:1.31-3.39), respectively, regardless of age, stage, treatment protocol, and time to treatment initiation. Conclusion: Delays in cervical cancer treatment conclusion (but not treatment initiation) affected 36-month survival and death risk among Brazilians. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Brazil; Cervical cancer; Delays in treatment; Epidemiology; Hospital-based cohort |
| تواريخ الأحداث: | Date Created: 20230907 Latest Revision: 20231005 |
| رمز التحديث: | 20231006 |
| DOI: | 10.1016/j.canep.2023.102450 |
| PMID: | 37678095 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1877-783X |
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| DOI: | 10.1016/j.canep.2023.102450 |