دورية أكاديمية
Discovery of novel benzofuran-based derivatives as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease: Design, synthesis, biological evaluation, molecular docking and 3D-QSAR investigation.
العنوان: | Discovery of novel benzofuran-based derivatives as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease: Design, synthesis, biological evaluation, molecular docking and 3D-QSAR investigation. |
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المؤلفون: | Abd El-Karim SS; Department of Therapeutic Chemistry, National Research Centre, P.O. Box 12262 El-Bohouth St, Cairo, Egypt. Electronic address: ssabdelkarim@gmail.com., Anwar MM; Department of Therapeutic Chemistry, National Research Centre, P.O. Box 12262 El-Bohouth St, Cairo, Egypt. Electronic address: manal.hasan52@live.com., Ahmed NS; Department of Therapeutic Chemistry, National Research Centre, P.O. Box 12262 El-Bohouth St, Cairo, Egypt., Syam YM; Department of Therapeutic Chemistry, National Research Centre, P.O. Box 12262 El-Bohouth St, Cairo, Egypt., Elseginy SA; Green Chemistry Department, Chemical Industries Research Division, National Research Centre, P. O. Box 12622, El-Bohouth St, Dokki, Cairo, Egypt., Aly HF; Department of Therapeutic Chemistry, National Research Centre, P.O. Box 12262 El-Bohouth St, Cairo, Egypt., Younis EA; Department of Therapeutic Chemistry, National Research Centre, P.O. Box 12262 El-Bohouth St, Cairo, Egypt., Khalil WKB; Department of Cell Biology, National Research Centre, P.O. Box 12262 El-Bohouth St, Dokki, Cairo, Egypt., Ahmed KA; Pathology Departments, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt., Mohammed FF; Pathology Departments, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt., Rizk M; Department of Therapeutic Chemistry, National Research Centre, P.O. Box 12262 El-Bohouth St, Cairo, Egypt. |
المصدر: | European journal of medicinal chemistry [Eur J Med Chem] 2023 Nov 15; Vol. 260, pp. 115766. Date of Electronic Publication: 2023 Aug 28. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Paris : Editions Scientifiques Elsevier Original Publication: Paris, S.E.C.T. [etc.] |
مواضيع طبية MeSH: | Alzheimer Disease*/drug therapy , Benzofurans*/pharmacology, Animals ; Rats ; Cholinesterase Inhibitors/pharmacology ; Donepezil ; Acetylcholinesterase ; Molecular Docking Simulation ; Quantitative Structure-Activity Relationship ; Glutathione |
مستخلص: | A series of novel benzofuran-based compounds 7a-s were designed, synthesized, and investigated in vitro as acetylcholinesterase inhibitors (AChEIs). Compounds 7c and 7e displayed promising inhibitory activity with IC Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Masson SAS. All rights reserved.) |
فهرسة مساهمة: | Keywords: 3D-QSAR; Acetylcholinesterase inhibitors; Alzheimer's disease; Benzofuran; Donepezil; Molecular docking |
المشرفين على المادة: | 0 (Cholinesterase Inhibitors) 8SSC91326P (Donepezil) EC 3.1.1.7 (Acetylcholinesterase) 0 (Benzofurans) GAN16C9B8O (Glutathione) |
تواريخ الأحداث: | Date Created: 20230907 Date Completed: 20230918 Latest Revision: 20230918 |
رمز التحديث: | 20230918 |
DOI: | 10.1016/j.ejmech.2023.115766 |
PMID: | 37678141 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1768-3254 |
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DOI: | 10.1016/j.ejmech.2023.115766 |