دورية أكاديمية
Spatial and phylogenetic patterns reveal hidden infection sources of Bacillus anthracis in an anthrax outbreak in Son La province, Vietnam.
| العنوان: | Spatial and phylogenetic patterns reveal hidden infection sources of Bacillus anthracis in an anthrax outbreak in Son La province, Vietnam. |
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| المؤلفون: | Metrailer MC; Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, FL, USA; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA., Hoang TTH; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Jiranantasak T; Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, FL, USA; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA., Luong T; Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, FL, USA; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Hoa LM; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Ngoc DB; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Pham QT; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Pham VK; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Hung TTM; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Huong VTL; Department of Animal Health, Hanoi, Viet Nam., Pham TL; Department of Animal Health, Hanoi, Viet Nam., Ponciano JM; Department of Biology, University of Florida, USA., Hamerlinck G; Department of Geography, University of Florida, Gainesville, FL, USA., Dang DA; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Norris MH; Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, FL, USA; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA., Blackburn JK; Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, FL, USA; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA. Electronic address: jkblackburn@ufl.edu. |
| المصدر: | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2023 Oct; Vol. 114, pp. 105496. Date of Electronic Publication: 2023 Sep 07. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101084138 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1567-7257 (Electronic) Linking ISSN: 15671348 NLM ISO Abbreviation: Infect Genet Evol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier Science, c2001- |
| مواضيع طبية MeSH: | Anthrax*/epidemiology , Anthrax*/veterinary , Anthrax*/microbiology , Bacillus anthracis*, Animals ; Humans ; Phylogeny ; Vietnam/epidemiology ; Nuclear Family ; Polymorphism, Single Nucleotide ; Genotype ; Disease Outbreaks |
| مستخلص: | Bacillus anthracis, the bacterial cause of anthrax, is a zoonosis affecting livestock and wildlife often spilling over into humans. In Vietnam, anthrax has been nationally reportable since 2015 with cases occurring annually, mostly in the northern provinces. In April 2022, an outbreak was reported in Son La province following the butchering of a water buffalo, Bubalus bubalis. A total of 137 humans from three villages were likely exposed to contaminated meat from the animal. Early epidemiological investigations suggested a single animal was involved in all exposures. Five B. anthracis isolates were recovered from human clinical cases along with one from the buffalo hide, another from associated maggots, and one from soil at the carcass site. The isolates were whole genome sequenced, allowing global, regional, and local molecular epidemiological analyses of the outbreak strains. All recovered B. anthracis belong to the A.Br.001/002 lineage based on canonical single nucleotide polymorphism analysis (canSNP). Although not previously identified in Vietnam, this lineage has been identified in the nearby countries of China, India, Indonesia, Thailand, as well as Australia. A twenty-five marker multi-locus variable number tandem repeat analysis (MLVA-25) was used to investigate the relationship between human, soil, and buffalo strains. Locally, four MLVA-25 genotypes were identified from the eight isolates. This level of genetic diversity is unusual for the limited geography and timing of cases and differs from past literature using MLVA-25. The coupled spatial and phylogenetic data suggest this outbreak originated from multiple, likely undetected, animal sources. These findings were further supported by local news reports that identified at least two additional buffalo deaths beyond the initial animal sampled in response to the human cases. Future outbreak response should include intensive surveillance for additional animal cases and additional molecular epidemiological traceback to identify pathogen sources. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: MLVA-25; Molecular epidemiology; Outbreak; Vietnam; Zoonosis; anthrax |
| تواريخ الأحداث: | Date Created: 20230907 Date Completed: 20231002 Latest Revision: 20231003 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.meegid.2023.105496 |
| PMID: | 37678701 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1567-7257 |
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| DOI: | 10.1016/j.meegid.2023.105496 |