دورية أكاديمية
Endogenous estradiol contributes to vascular endothelial dysfunction in premenopausal women with type 1 diabetes.
| العنوان: | Endogenous estradiol contributes to vascular endothelial dysfunction in premenopausal women with type 1 diabetes. |
|---|---|
| المؤلفون: | Simon AB; Georgia Prevention Institute, Medical College of Georgia, Augusta University, 1120 15th Street, HS-1707, Augusta, GA, 30912, Georgia., Derella CC; Georgia Prevention Institute, Medical College of Georgia, Augusta University, 1120 15th Street, HS-1707, Augusta, GA, 30912, Georgia., Blackburn M; Georgia Prevention Institute, Medical College of Georgia, Augusta University, 1120 15th Street, HS-1707, Augusta, GA, 30912, Georgia., Thomas J; Georgia Prevention Institute, Medical College of Georgia, Augusta University, 1120 15th Street, HS-1707, Augusta, GA, 30912, Georgia., Layman LC; Section of Reproductive Endocrinology, Infertility, & Genetics, Department of Obstetrics & Gynecology, Medical College of Georgia, Augusta University, Augusta, GA, Georgia., Nicholson MS; Department of Endocrinology, Medical College of Georgia, Augusta University, Augusta, GA, Georgia., Waller J; Department of Biostatistics and Data Science, Medical College of Georgia, Augusta University, Augusta, GA, Georgia., Elmarakby A; Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, Georgia., Saad KM; Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, Georgia., Harris RA; Georgia Prevention Institute, Medical College of Georgia, Augusta University, 1120 15th Street, HS-1707, Augusta, GA, 30912, Georgia. ryharris@augusta.edu. |
| المصدر: | Cardiovascular diabetology [Cardiovasc Diabetol] 2023 Sep 07; Vol. 22 (1), pp. 243. Date of Electronic Publication: 2023 Sep 07. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101147637 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2840 (Electronic) Linking ISSN: 14752840 NLM ISO Abbreviation: Cardiovasc Diabetol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2002- |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 1*/diagnosis , Diabetes Mellitus, Type 1*/drug therapy , Vascular Diseases*, Female ; Animals ; Estradiol ; Thiobarbituric Acid Reactive Substances ; Estrogens |
| مستخلص: | Background: Endogenous estrogen is cardio-protective in healthy premenopausal women. Despite this favorable action of estrogen, animal models depict a detrimental effect of estradiol on vascular function in the presence of diabetes. The present study sought to determine the role of endogenous estradiol on endothelial function in women with type 1 diabetes. Method: 32 women with type 1 diabetes (HbA Results: Overall, estradiol was significantly increased during the LF phase compared to M in both type 1 diabetes (Δestradiol = 75 ± 86 pg/mL) and controls (Δestradiol = 71 ± 76 pg/mL); however, an increase in TBARS was only observed in patients with type 1 diabetes (ΔTBARS = 3 ± 13 µM) compared to controls (ΔTBARS = 0 ± 4 µM). FMD was similar (p = 0.406) between groups at M. In addition, FMD increased significantly from M to the LF phase in controls (p = 0.024), whereas a decrease was observed in type 1 diabetes. FMD was greater (p = 0.015) in patients using HBC compared to those not on HBC, independent of menstrual cycle phase. Conclusion: Endogenous estradiol increases oxidative stress and contributes to endothelial dysfunction in women with diabetes. Additionally, HBC use appears to be beneficial to endothelial function in type 1 diabetes. (© 2023. BioMed Central Ltd., part of Springer Nature.) |
| References: | Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, et al. Global Burden of Cardiovascular Diseases and Risk factors, 1990–2019: Update from the GBD 2019 study. J Am Coll Cardiol. 2020;76(25):2982–3021. (PMID: 10.1016/j.jacc.2020.11.010333091757755038) Mosca L, Barrett-Connor E, Wenger NK. Sex/gender differences in cardiovascular disease prevention: what a difference a decade makes. Circulation. 2011;124(19):2145–54. (PMID: 10.1161/CIRCULATIONAHA.110.968792220649583362050) Lee SI, Patel M, Jones CM, Narendran P. Cardiovascular disease and type 1 diabetes: prevalence, prediction and management in an ageing population. Ther Adv Chronic Dis. 2015;6(6):347–74. (PMID: 10.1177/2040622315598502265688114622313) Lind M, Svensson AM, Kosiborod M, Gudbjörnsdottir S, Pivodic A, Wedel H, et al. Glycemic control and excess mortality in type 1 diabetes. N Engl J Med. 2014;371(21):1972–82. (PMID: 10.1056/NEJMoa140821425409370) Iorga A, Cunningham CM, Moazeni S, Ruffenach G, Umar S, Eghbali M. The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy. Biol Sex Differ. 2017;8(1):33. (PMID: 10.1186/s13293-017-0152-8290659275655818) Huxley RR, Peters SA, Mishra GD, Woodward M. Risk of all-cause mortality and vascular events in women versus men with type 1 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2015;3(3):198–206. (PMID: 10.1016/S2213-8587(14)70248-725660575) de Ritter R, de Jong M, Vos RC, van der Kallen CJH, Sep SJS, Woodward M, et al. Sex differences in the risk of vascular disease associated with diabetes. Biol Sex Differ. 2020;11(1):1. (PMID: 10.1186/s13293-019-0277-z319002286942348) Braffett BH, Bebu I, El Ghormli L, Cowie CC, Sivitz WI, Pop-Busui R, et al. Cardiometabolic risk factors and Incident Cardiovascular Disease events in women vs men with type 1 diabetes. JAMA Netw Open. 2022;5(9):e2230710. (PMID: 10.1001/jamanetworkopen.2022.30710360744619459657) Mihm M, Gangooly S, Muttukrishna S. The normal menstrual cycle in women. Anim Reprod Sci. 2011;124(3–4):229–36. (PMID: 10.1016/j.anireprosci.2010.08.03020869180) Khalil RA. Estrogen, vascular estrogen receptor and hormone therapy in postmenopausal vascular disease. Biochem Pharmacol. 2013;86(12):1627–42. (PMID: 10.1016/j.bcp.2013.09.02424099797) White RE. Estrogen and vascular function. Vascul Pharmacol. 2002;38(2):73–80. (PMID: 10.1016/S0306-3623(02)00129-512379953) Borrás C, Gambini J, López-Grueso R, Pallardó FV, Viña J. Direct antioxidant and protective effect of estradiol on isolated mitochondria. Biochim Biophys Acta. 2010;1802(1):205–11. (PMID: 10.1016/j.bbadis.2009.09.00719751829) Bruno RM, Bianchini E, Faita F, Taddei S, Ghiadoni L. Intima media thickness, pulse wave velocity, and flow mediated dilation. Cardiovasc Ultrasound. 2014;12:34. (PMID: 10.1186/1476-7120-12-34251489014154051) Harris RA, Tedjasaputra V, Zhao J, Richardson RS. Premenopausal women exhibit an inherent protection of endothelial function following a high-fat meal. Reprod Sci. 2012;19(2):221–8. (PMID: 10.1177/1933719111418125223837603343134) Adkisson EJ, Casey DP, Beck DT, Gurovich AN, Martin JS, Braith RW. Central, peripheral and resistance arterial reactivity: fluctuates during the phases of the menstrual cycle. Exp Biol Med (Maywood). 2010;235(1):111–8. (PMID: 10.1258/ebm.2009.00918620404025) Williams MR, Westerman RA, Kingwell BA, Paige J, Blombery PA, Sudhir K, et al. Variations in endothelial function and arterial compliance during the menstrual cycle. J Clin Endocrinol Metab. 2001;86(11):5389–95. (PMID: 10.1210/jcem.86.11.801311701712) Hashimoto M, Akishita M, Eto M, Ishikawa M, Kozaki K, Toba K, et al. Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex and menstrual cycle. Circulation. 1995;92(12):3431–5. (PMID: 10.1161/01.CIR.92.12.34318521564) Brandão AHF, Serra PJ, Zanolla K, Cabral ACV, Geber S. Variation of endothelial function during the menstrual cycle evaluated by flow-mediated dilatation of brachial artery. JBRA Assist Reprod. 2014;18(4):148–50. (PMID: 10.5935/1518-0557.20140022357617449239413) Shenouda N, Priest SE, Rizzuto VI, MacDonald MJ. Brachial artery endothelial function is stable across a menstrual and oral contraceptive pill cycle but lower in premenopausal women than in age-matched men. Am J Physiol Heart Circ Physiol. 2018;315(2):H366–h74. (PMID: 10.1152/ajpheart.00102.201829727219) White RE, Han G, Dimitropoulou C, Zhu S, Miyake K, Fulton D, et al. Estrogen-induced contraction of coronary arteries is mediated by superoxide generated in vascular smooth muscle. Am J Physiol Heart Circ Physiol. 2005;289(4):H1468–75. (PMID: 10.1152/ajpheart.01173.200416162867) Britton LE, Alspaugh A, Greene MZ, McLemore MR. CE: an evidence-based update on Contraception. Am J Nurs. 2020;120(2):22–33. (PMID: 10.1097/01.NAJ.0000654304.29632.a7319774147533104) Teal S, Edelman A. Contraception Selection, Effectiveness, and adverse Effects: a review. JAMA. 2021;326(24):2507–18. (PMID: 10.1001/jama.2021.2139234962522) Rivera R, Yacobson I, Grimes D. The mechanism of action of hormonal contraceptives and intrauterine contraceptive devices. Am J Obstet Gynecol. 1999;181(5 Pt 1):1263–9. (PMID: 10.1016/S0002-9378(99)70120-110561657) Kaminski P, Szpotanska-Sikorska M, Wielgos M. Cardiovascular risk and the use of oral contraceptives. Neuro Endocrinol Lett. 2013;34(7):587–9. (PMID: 24464000) Harris RA, Nishiyama SK, Wray DW, Richardson RS. Ultrasound assessment of flow-mediated dilation. Hypertension. 2010;55(5):1075–85. (PMID: 10.1161/HYPERTENSIONAHA.110.15082120351340) Lakens D. Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Front Psychol. 2013;4:863. (PMID: 10.3389/fpsyg.2013.00863243244493840331) Cutolo M, Capellino S, Sulli A, Serioli B, Secchi ME, Villaggio B, et al. Estrogens and autoimmune diseases. Ann N Y Acad Sci. 2006;1089:538–47. (PMID: 10.1196/annals.1386.04317261796) Losordo DW, Isner JM. Estrogen and angiogenesis: a review. Arterioscler Thromb Vasc Biol. 2001;21(1):6–12. (PMID: 10.1161/01.ATV.21.1.611145928) García-Gómez E, Vázquez-Martínez ER, Reyes-Mayoral C, Cruz-Orozco OP, Camacho-Arroyo I, Cerbón M. Regulation of inflammation pathways and Inflammasome by Sex Steroid Hormones in Endometriosis. Front Endocrinol (Lausanne). 2019;10:935. (PMID: 10.3389/fendo.2019.0093532063886) Green DJ, Jones H, Thijssen D, Cable NT, Atkinson G. Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter? Hypertension. 2011;57(3):363–9. (PMID: 10.1161/HYPERTENSIONAHA.110.16701521263128) Katerndahl DA, Realini JP, Cohen PA. Oral contraceptive use and cardiovascular disease: is the relationship real or due to study bias? J Fam Pract. 1992;35(2):147–57. (PMID: 1386621) Stampfer MJ, Willett WC, Colditz GA, Speizer FE, Hennekens CH. A prospective study of past use of oral contraceptive agents and risk of cardiovascular diseases. N Engl J Med. 1988;319(20):1313–7. (PMID: 10.1056/NEJM1988111731920043185634) Chen Z, Yuhanna IS, Galcheva-Gargova Z, Karas RH, Mendelsohn ME, Shaul PW. Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen. J Clin Invest. 1999;103(3):401–6. (PMID: 10.1172/JCI53479927501407904) Brenner PF, Mishell DR Jr, Stanczyk FZ, Goebelsmann U. Serum levels of d-norgestrel, luteinizing hormone, follicle-stimulating hormone, estradiol, and progesterone in women during and following ingestion of combination oral contraceptives containing dl-norgestrel. Am J Obstet Gynecol. 1977;129(2):133–40. (PMID: 10.1016/0002-9378(77)90733-5900174) Duffy DM, Ko C, Jo M, Brannstrom M, Curry TE. Ovulation: parallels with inflammatory processes. Endocr Rev. 2019;40(2):369–416. (PMID: 10.1210/er.2018-0007530496379) |
| معلومات مُعتمدة: | R01 HL137087 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: Diabetes; Endothelial function; Estrogen; Oral contraceptives |
| المشرفين على المادة: | 4TI98Z838E (Estradiol) 0 (Thiobarbituric Acid Reactive Substances) 0 (Estrogens) |
| تواريخ الأحداث: | Date Created: 20230907 Date Completed: 20230911 Latest Revision: 20231119 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10486136 |
| DOI: | 10.1186/s12933-023-01966-6 |
| PMID: | 37679748 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1475-2840 |
|---|---|
| DOI: | 10.1186/s12933-023-01966-6 |