دورية أكاديمية
Correlation of ultrasound features with Bcl-2 protein expression in basal cell carcinomas (BCCs).
| العنوان: | Correlation of ultrasound features with Bcl-2 protein expression in basal cell carcinomas (BCCs). |
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| المؤلفون: | Luo PP; Department of Ultrasound, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong, China., Chen YX; Department of Ultrasound, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong, China., Zhong ZR; Department of Ultrasound, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong, China., Feng MC; Department of Ultrasound, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong, China., Wang J; Department of Pathology, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong, China., Liang JF; Department of Ultrasound, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong, China. |
| المصدر: | Journal of clinical ultrasound : JCU [J Clin Ultrasound] 2023 Nov-Dec; Vol. 51 (9), pp. 1615-1621. Date of Electronic Publication: 2023 Sep 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Subscription Services, Inc Country of Publication: United States NLM ID: 0401663 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0096 (Electronic) Linking ISSN: 00912751 NLM ISO Abbreviation: J Clin Ultrasound Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005-> : Hoboken, N.J. : Wiley Subscription Services, Inc. Original Publication: Denver, Colo. : Norman House, c1973- |
| مواضيع طبية MeSH: | Carcinoma, Basal Cell*/diagnostic imaging , Carcinoma, Basal Cell*/metabolism , Carcinoma, Basal Cell*/pathology , Skin Neoplasms*/diagnostic imaging , Skin Neoplasms*/pathology, Humans ; Retrospective Studies ; Ultrasonography |
| مستخلص: | Background: The expression of the Bcl-2 protein is frequently observed in basal cell carcinomas (BCCs), making it a significant biological marker and potential therapeutic target. Skin ultrasonography offers a noninvasive means of obtaining anatomical information about cutaneous tumors. Objectives: The purpose of this study was to investigate the correlation between ultrasound features and Bcl-2 expression in BCCs, to provide a reference for developing pharmacological treatment plans. Methods: According to the Bcl-2 protein expression, 74 BCCs confirmed by surgical pathology were divided into high Bcl-2 expression BCCs (HB-BCCs) and low Bcl-2 expression BCCs (LB-BCCs). Preoperative lesion ultrasound features were analyzed retrospectively based on Liang's criteria, which included the following features: shape, surface, keratinization, base, infiltration level, internal echogenicity, distribution of hyperechoic spots, posterior echogenic changes, internal Doppler signal, and lesion size (maximum diameter and infiltration depth). The differences of two groups were compared using a chi-square test or a paired t-test. Results: Based on ultrasound features, cystic areas were more frequent in LB-BCCs (χ 2 = 7.015, P = .008). Furthermore, LB-BCCs exhibited greater infiltration depth than HB-BCCs (4.86 ± 2.12 mm vs. 2.72 ± 1.40 mm, P = .000), had a higher propensity to infiltrate the subcutaneous tissue (χ 2 = 12.422, P = .002), and displayed a more abundant internal Doppler signal within the lesions (χ 2 = 24.696, P = .000). Conversely, maximum diameter of the lesions, shape, surface, keratinization, base, hyperechoic spots distribution, and posterior echogenic changes of the lesions did not differ significantly between the two groups. Conclusions: Ultrasound features are correlated with Bcl-2 protein expression level in BCCs. LB-BCCs show greater infiltration depth, subcutaneous infiltration, more cystic changes and more abundant internal Doppler signal than HB-BCCs, which may suggest a potential basis for drug selection in BCC chemotherapy. (© 2023 Wiley Periodicals LLC.) |
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| معلومات مُعتمدة: | 2020B1078 Social Public Welfare and Basic Research Projects of Zhongshan city (Medical and Health Care) |
| فهرسة مساهمة: | Keywords: Bcl-2 protein expression; basal cell carcinoma; correlation; ultrasound features |
| تواريخ الأحداث: | Date Created: 20230908 Date Completed: 20231122 Latest Revision: 20231122 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1002/jcu.23554 |
| PMID: | 37680166 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-0096 |
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| DOI: | 10.1002/jcu.23554 |