دورية أكاديمية
أعرض في EDS

Screening the Extract of Laportea bulbifera (Sieb. et Zucc.) Wedd. Based on Active Component Content, Its Antioxidant Capacity and Exploration of Hepatoprotective Activity in Rats.

التفاصيل البيبلوغرافية
العنوان: Screening the Extract of Laportea bulbifera (Sieb. et Zucc.) Wedd. Based on Active Component Content, Its Antioxidant Capacity and Exploration of Hepatoprotective Activity in Rats.
المؤلفون: Feng J; College of Pharmacy, Yanbian University, Yanji 133000, China.; Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China., Sun Y; College of Pharmacy, Yanbian University, Yanji 133000, China.; Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China., Wei Z; Institute of Scientific and Technical Information of Jilin, Changchun 130033, China., Sun H; Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China., Li L; College of Pharmacy, Yanbian University, Yanji 133000, China.; Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China., Zhu J; Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China.; Key Laboratory of Evaluation and Application of Changbai Mountain Biological Gerplasm Resources of Jilin Province, Tonghua 134002, China., Xia G; College of Pharmacy, Yanbian University, Yanji 133000, China.; Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China.; Key Laboratory of Evaluation and Application of Changbai Mountain Biological Gerplasm Resources of Jilin Province, Tonghua 134002, China., Zang H; College of Pharmacy, Yanbian University, Yanji 133000, China.; Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China.; Key Laboratory of Evaluation and Application of Changbai Mountain Biological Gerplasm Resources of Jilin Province, Tonghua 134002, China.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2023 Aug 25; Vol. 28 (17). Date of Electronic Publication: 2023 Aug 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Antioxidants*/pharmacology , Urticaceae*, Humans ; Animals ; Rats ; Methanol ; Solvents ; Biological Assay ; Ethanol ; Phenols/pharmacology
مستخلص: Laportea bulbifera (Sieb. et Zucc.) Wedd., a plant with a long history of medicinal use, possesses uncertainly defined medicament portions while its antioxidant capacity remains largely unexplored. To gain a better understanding of its medicinal value, this study focused on investigating the Laportea bulbifera aboveground part (LBAP) and the Laportea bulbifera root (LBR). Through an assessment of the bioactive compound content, a significant finding emerged: the LBR exhibited notably higher levels of these bioactive phytochemicals compared to the LBAP. This observation was further reinforced by the antioxidant assays, which demonstrated the superiority of the LBR's antioxidant capacity. The experimental results unequivocally indicate that the root is the optimal medicament portion for Laportea bulbifera . Furthermore, it was discovered that the presence of alcohol in the extraction solvent significantly enhanced the extraction of active ingredients, with the methanol extract of LBR performing the best among the extracts tested. Consequently, this extract was selected for further research. Leveraging cutting-edge UHPLC-ESI-Q-TOF-MS technology, the methanol extract of LBR was meticulously analyzed, revealing the presence of 41 compounds, primarily belonging to the phenolics and fatty acids. Remarkably, stability experiments demonstrated that the phenolics in the methanol extract maintained their stability across various pH values and during in vitro simulations of the human digestive system, albeit showing gradual degradation under high temperatures. Furthermore, the oxidative stability tests conducted on oils revealed the potential of the methanol extract as a stabilizer for olive oil and sunflower oil. Moreover, oral acute toxicity studies confirmed the low toxicity of the methanol extract, further supporting its safe use for medicinal purposes. Of particular note, histopathological examination and biochemical analysis affirmed the remarkable protective effects of the methanol extract against d-galactosamine-induced liver damage. These findings underscore the therapeutic potential of the methanol extract from the LBR in the treatment of diseases associated with oxidative imbalance.
References: Molecules. 2022 Apr 08;27(8):. (PMID: 35458611)
Front Pharmacol. 2021 Nov 16;12:756724. (PMID: 34867374)
J Wound Care. 2020 Oct 1;29(Sup10a):S4-S8. (PMID: 33016847)
Metabolites. 2018 Nov 27;8(4):. (PMID: 30486444)
Nat Rev Gastroenterol Hepatol. 2021 Jan;18(1):40-55. (PMID: 32764740)
Food Chem. 2022 Jul 30;383:132531. (PMID: 35413752)
Food Chem. 2014 Feb 15;145:57-65. (PMID: 24128449)
Org Lett. 2018 Sep 21;20(18):5861-5865. (PMID: 30192550)
J Ethnopharmacol. 2019 Aug 10;240:111940. (PMID: 31071423)
Sci Rep. 2020 Jun 17;10(1):9762. (PMID: 32555290)
Inflamm Bowel Dis. 2022 Aug 1;28(8):1280-1288. (PMID: 35312776)
Life (Basel). 2023 May 29;13(6):. (PMID: 37374056)
J Ethnopharmacol. 2011 Nov 18;138(2):523-9. (PMID: 22001857)
Rapid Commun Mass Spectrom. 2011 Dec 30;25(24):3690-6. (PMID: 22468326)
Food Chem. 2021 Aug 15;353:129488. (PMID: 33714793)
Molecules. 2014 Jul 04;19(7):9535-51. (PMID: 25000465)
EXCLI J. 2013 Oct 28;12:894-906. (PMID: 27092035)
Angew Chem Int Ed Engl. 2013 Jan 2;52(1):310-4. (PMID: 23055437)
Medchemcomm. 2019 May 31;10(7):1192-1196. (PMID: 31741729)
J Ethnopharmacol. 2019 Jul 15;239:111854. (PMID: 30954614)
Arch Toxicol. 2020 Mar;94(3):651-715. (PMID: 32180036)
Molecules. 2023 Mar 27;28(7):. (PMID: 37049747)
Molecules. 2022 Nov 21;27(22):. (PMID: 36432187)
Nat Prod Res. 2022 Oct;36(19):5048-5052. (PMID: 33858290)
Fungal Biol. 2022 Oct;126(10):674-686. (PMID: 36116899)
Phytochem Anal. 2022 Apr;33(3):402-426. (PMID: 34907611)
Biomed Pharmacother. 2023 Apr;160:114413. (PMID: 36805187)
Chemosphere. 2021 May;271:129499. (PMID: 33445014)
Food Chem X. 2022 Mar 16;14:100285. (PMID: 35342880)
Free Radic Res. 2003 Mar;37(3):309-16. (PMID: 12688426)
Nutrients. 2021 Jan 19;13(1):. (PMID: 33477894)
Chem Biodivers. 2022 Jul;19(7):e202200070. (PMID: 35620918)
Biomed Pharmacother. 2020 May;125:110020. (PMID: 32106375)
Biomed Pharmacother. 2021 Aug;140:111596. (PMID: 34126315)
Bioorg Chem. 2019 Aug;89:103043. (PMID: 31200287)
Molecules. 2022 Jul 27;27(15):. (PMID: 35956760)
Food Chem. 2019 Mar 30;277:279-288. (PMID: 30502146)
Joint Bone Spine. 2019 Oct;86 Suppl 1:eS2-eS103. (PMID: 31791545)
Nat Prod Res. 2019 Apr;33(8):1233-1236. (PMID: 29683369)
Molecules. 2019 Jan 02;24(1):. (PMID: 30609767)
Biomed Chromatogr. 2020 Feb;34(2):e4734. (PMID: 31692001)
Phytomedicine. 2023 Jan;108:154498. (PMID: 36272383)
Molecules. 2022 Oct 21;27(20):. (PMID: 36296710)
Food Chem. 2022 Nov 15;394:133461. (PMID: 35728467)
معلومات مُعتمدة: YDZJ202301ZYTS171 Science and Technology Development Plan Project of Jilin Province; YDZJ202201ZYTS186 Science and Technology Development Plan Project of Jilin Province
فهرسة مساهمة: Keywords: Laportea bulbifera (Sieb. et Zucc.) Wedd.; antioxidant activity; liver damage; phytochemical analysis
المشرفين على المادة: 0 (Antioxidants)
Y4S76JWI15 (Methanol)
0 (Solvents)
3K9958V90M (Ethanol)
0 (Phenols)
تواريخ الأحداث: Date Created: 20230909 Date Completed: 20230911 Latest Revision: 20230911
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10488916
DOI: 10.3390/molecules28176256
PMID: 37687084
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules28176256