دورية أكاديمية
أعرض في EDS

Plerixafor in autologous stem cell transplantation: Does it affect engraftment kinetics?

التفاصيل البيبلوغرافية
العنوان: Plerixafor in autologous stem cell transplantation: Does it affect engraftment kinetics?
المؤلفون: Serin I; University of Health Sciences, Istanbul Training and Research Hospital, Department of Hematology, Istanbul, Turkey. Electronic address: serinistemi@hotmail.com., Sevindik OG; Istanbul Medipol University, Faculty of Medicine, Department of Hematology, Istanbul, Turkey., Balik Aydin B; Istanbul Medipol University, Faculty of Medicine, Department of Hematology, Istanbul, Turkey., Melek E; Istanbul Medipol University, Faculty of Medicine, Department of Hematology, Istanbul, Turkey., Mutlu YG; Istanbul Medipol University, Faculty of Medicine, Department of Hematology, Istanbul, Turkey., Bilgen H; Istanbul Medipol University, Faculty of Medicine, Department of Hematology, Istanbul, Turkey., Bekoz H; Istanbul Medipol University, Faculty of Medicine, Department of Hematology, Istanbul, Turkey., Kaynar L; Istanbul Medipol University, Faculty of Medicine, Department of Hematology, Istanbul, Turkey.
المصدر: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis [Transfus Apher Sci] 2023 Dec; Vol. 62 (6), pp. 103809. Date of Electronic Publication: 2023 Sep 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Pergamon Country of Publication: England NLM ID: 101095653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-0502 (Print) Linking ISSN: 14730502 NLM ISO Abbreviation: Transfus Apher Sci
أسماء مطبوعة: Original Publication: Oxford : Pergamon : Elsevier Science, c2001-
مواضيع طبية MeSH: Hematopoietic Stem Cell Transplantation*/methods , Heterocyclic Compounds*/pharmacology , Heterocyclic Compounds*/therapeutic use , Febrile Neutropenia* , Multiple Myeloma*/therapy, Adult ; Humans ; Hematopoietic Stem Cell Mobilization/methods ; Transplantation, Autologous ; Granulocyte Colony-Stimulating Factor/pharmacology ; Antigens, CD34/metabolism
مستخلص: Plerixafor increases stem cell mobilization by reversibly binding to the chemokine receptor CXCR4. In our study, we examined the results of mobilization with plerixafor and granulocyte colony-stimulating factor (G-CSF) and revealed their effects on autologous stem cell transplantation (ASCT) engraftment kinetics. The study included all cases of ASCT performed in the Adult Bone Marrow Transplantation Unit of xxx University between January 2014 and January 2022. It included a total of 300 patients. The total number of CD34 + cells collected was 7.44 ± 4.19 in patients with plerixafor and 9.53 ± 6.09 in patients without plerixafor. The mean neutrophil and platelet engraftment took longer in plerixafor-mobilized patients (neutrophil: 12 ± 4.1 vs. 10.2 ± 2.7 days; platelet: 21.6 ± 13.9 vs. 14.2 ± 5.9 days; p = 0.008 and p = 0.002). The number of febrile neutropenia attacks was significantly higher in plerixafor-mobilized patients (p = 0.04). In the chemo-mobilized patient subgroup, plerixafor-mobilized patients experienced more febrile neutropenia attacks (p = 0.04). The mean time to both neutrophil and platelet engraftment was longer in patients mobilized with plerixafor. In the subgroup of patients with MM, the mean time to platelet engraftment was longer in patients mobilized with plerixafor. Plerixafor and its effect on engraftment kinetics should be evaluated with further studies in a larger population with survival analysis.
Competing Interests: Competing interests The authors declare that they have no competing interests.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Engraftment; Mobilization; Plerixafor; Prognosis; Stem cell transplantation
المشرفين على المادة: 0 (Heterocyclic Compounds)
143011-72-7 (Granulocyte Colony-Stimulating Factor)
0 (Antigens, CD34)
تواريخ الأحداث: Date Created: 20230910 Date Completed: 20231206 Latest Revision: 20231206
رمز التحديث: 20231206
DOI: 10.1016/j.transci.2023.103809
PMID: 37690861
قاعدة البيانات: MEDLINE
الوصف
تدمد:1473-0502
DOI:10.1016/j.transci.2023.103809