دورية أكاديمية
Comparison and effect of moxibustion and acupuncture on Nogo/NgR signaling pathway in rats with cerebral ischemia/reperfusion injury.
العنوان: | Comparison and effect of moxibustion and acupuncture on Nogo/NgR signaling pathway in rats with cerebral ischemia/reperfusion injury. |
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المؤلفون: | Min YJ; School of Traditional Chinese Medicine, Nanchang Medical College, Nanchang, 330052, Jiangxi, China.; Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, Jiangxi, China., Yao HH; Shanghai Eighth People's Hospital, Shanghai, 200235, Shanghai, China., Wang L; School of Traditional Chinese Medicine, Nanchang Medical College, Nanchang, 330052, Jiangxi, China., Cheng LH; Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, Jiangxi, China., Hong ES; Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, Jiangxi, China. |
المصدر: | Journal of traditional and complementary medicine [J Tradit Complement Med] 2023 Mar 22; Vol. 13 (5), pp. 430-440. Date of Electronic Publication: 2023 Mar 22 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier B.V. on behalf of the Center for Food and Biomolecules, National Taiwan University Country of Publication: Netherlands NLM ID: 101605474 Publication Model: eCollection Cited Medium: Print ISSN: 2225-4110 (Print) Linking ISSN: 22254110 NLM ISO Abbreviation: J Tradit Complement Med Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: Amsterdam : Elsevier B.V. on behalf of the Center for Food and Biomolecules, National Taiwan University Original Publication: Philadelphia, PA : [Taipei] : Wolters Kluwer Health, Medknow ; Committee on Chinese Medicine and Pharmacy |
مستخلص: | Background and Aim: In China, acupuncture and moxibustion have been used effectively to treat various diseases for thousands of years. However, the evidence for a difference in the efficacies of moxibustion and acupuncture in cerebral infarction treatment is scarce. We aimed to compare the effects of acupuncture and moxibustion treatment on the Nogo/NgR signaling pathway in rats with cerebral ischemia/reperfusion (I/R) injury. Experimental Procedure: Eighty male SD rats were randomly divided into five groups, based on treatment received: sham surgery (sham group), middle cerebral artery occlusion (MCAO, MCAO group), MCAO and NEP(1-40) inhibitor injection (MCAO + block group), MCAO and moxibustion (MCAO + moxi group), and MCAO and minimal acupuncture (MCAO + MA group). Neurological status was evaluated before treatment, and cerebral infarction volume (IV) and neurological function; Nogo-A, NgR, p75NTR, and LINGO-1 expressions; and NgR and LINGO-1 co-expression were assessed after treatment. Results and Conclusion: After treatment, barring Nogo-A mRNA and protein expression in the MCAO + block group, the Longa score and IV significantly decreased; Nogo-A, NgR, p75NTR, and LINGO-1 mRNA and protein expressions as well as NgR and LINGO-1 co-expression significantly decreased in cerebral tissues; whereas the BWT score increased (P < 0.01) in the MCAO + moxi group, compared with the MCAO group. Except for NgR and LINGO-1 protein expressions, there were no significant differences in the abovementioned parameters between rats that underwent acupuncture and moxibustion. Acupuncture and moxibustion have similar effects on Nogo/NgR signaling pathway inhibition after cerebral infarction. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.) |
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فهرسة مساهمة: | Keywords: Cerebral infarction; Myelin; Neural death; Neural restoration |
تواريخ الأحداث: | Date Created: 20230911 Latest Revision: 20230913 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10491986 |
DOI: | 10.1016/j.jtcme.2023.03.006 |
PMID: | 37693099 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2225-4110 |
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DOI: | 10.1016/j.jtcme.2023.03.006 |