دورية أكاديمية

What is the effect of Tribulus terrestris on testicular morphology and sperm production? An experimental study in the rat model.

التفاصيل البيبلوغرافية
العنوان: What is the effect of Tribulus terrestris on testicular morphology and sperm production? An experimental study in the rat model.
المؤلفون: Da Silva MHA; Urogenital Research Unit, Rio de Janeiro State University, Rio de Janeiro 20551-030, RJ, Brazil., Buys-Gonçalves GF, Estrada JHDR, Sampaio FJB, de Souza DB
المصدر: Asian journal of andrology [Asian J Androl] 2024 Jan 01; Vol. 26 (1), pp. 67-70. Date of Electronic Publication: 2023 Aug 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Shanghai Materia Medica Country of Publication: China NLM ID: 100942132 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7262 (Electronic) Linking ISSN: 1008682X NLM ISO Abbreviation: Asian J Androl Subsets: MEDLINE
أسماء مطبوعة: Publication: Shanghai : Shanghai Materia Medica
Original Publication: Beijing : Science Press,
مواضيع طبية MeSH: Tribulus* , Testis*/drug effects , Testis*/anatomy & histology , Testis*/pathology , Spermatozoa*/drug effects , Sperm Motility*/drug effects , Plant Extracts*/pharmacology, Animals ; Male ; Rats ; Sperm Count ; Rats, Wistar ; Spermatogenesis/drug effects ; Seminiferous Tubules/drug effects ; Organ Size/drug effects
مستخلص: The objective of this study was to investigate whether treatment with Tribulus terrestris (Tt) has any impact on the testicular morphology and function in a rodent model. Twenty male rats were divided into a control group and a group receiving 100 mg kg -1 body weight of Tt supplementation. After 40 days of experiment, the animals were submitted to euthanasia; epididymal tail spermatozoa were collected; and spermatozoa concentration, motility, and viability were analyzed. In addition, testicles were collected and processed for histomorphometrical analyses. Data were compared using the Student's t -test and considered significant when P < 0.05. Spermatozoa concentration, motility, and viability showed no difference between the groups. Further, testicular weight and volume, seminiferous tubule diameter, tunica propria surface density, seminiferous epithelium surface density, and intertubular compartment surface density were statistically similar between the groups. However, seminiferous epithelium height and tubular lumen surface density were augmented in animals treated with Tt. Treatment with Tt does not cause a major impact on testicular morphology, promoting only subtle modifications. No difference on spermatozoa parameters was observed.
(Copyright © 2023 Copyright: © The Author(s)(2023).)
References: Kumari M, Singh P. Tribulus terrestris improves metronidazole-induced impaired fertility in the male mice. Afr Health Sci 2018;18:645–52.
Salgado RM, Marques-Silva MH, Gonçalves E, Mathias AC, Aguiar JG, et al. Effect of oral administration of Tribulus terrestris extract on semen quality and body fat index of infertile men. Andrologia 2017;49:e12655.
Haghmorad D, Mahmoudi MB, Haghighi P, Alidadiani P, Shahvazian E, et al. Improvement of fertility parameters with Tribulus terrestris and Anacyclus pyrethrum treatment in male rats. Int Braz J Urol 2019;45:1043–54.
Shalaby MA, Hammouda AA. Assessment of protective and anti-oxidant properties of Tribulus terrestris fruits against testicular toxicity in rats. J Intercult Ethnopharmacol 2014;3:113–8.
Roaiah MF, Elkhayat YI, Abd El Salam MA, Din SF. Prospective analysis on the effect of botanical medicine ( Tribulus terrestris ) on serum testosterone level and semen parameters in males with unexplained infertility. J Diet Suppl 2017;14:25–31.
Fernández-Lázaro D, Mielgo-Ayuso J, Del Valle Soto M, Adams DP, González-Bernal JJ, et al. The effects of 6 weeks of Tribulus terrestris L. Supplementation on body composition, hormonal response, perceived exertion, and CrossFit ® performance: a randomized, single-blind, placebo-controlled study. Nutrients 2021;13:3969.
Fernández-Lázaro D, Fernandez-Lazaro CI, Seco-Calvo J, Garrosa E, Adams DP, et al. Effects of Tribulus terrestris L. On sport and health biomarkers in physically active adult males: a systematic review. Int J Environ Res Public Health 2022;19:9533.
Gauthaman K, Ganesan AP. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction –an evaluation using primates, rabbit and rat. Phytomedicine 2008;15:44–54.
Adeldust H, Farzinpour A, Farshad A, Rostamzadeh J, Lopez-Bejar M. Increased sperm cell production in ageing roosters by an oral treatment with an aromatase inhibitor and a natural herbal extract designed for improving fertility. Reprod Domest Anim 2017;52:58–60.
Kavitha P, Ramesh R, Subramanian P. Histopathological changes in Poecilia latipinna male gonad due to Tribulus terrestris administration. In Vitro Cell Dev Biol Anim 2012;48:306–12.
Arafa MH, Amin DM, Samir GM, Atteia HH. Protective effects of Tribulus terrestris extract and angiotensin blockers on testis steroidogenesis in copper overloaded rats. Ecotoxicol Environ Saf 2019;178:113–22.
Chorosho SH, Malik N, Panesar G, Kumari P, Jangra S, et al. Phytochemicals: alternative for infertility treatment and associated conditions. Oxid Med Cell Longev 2023 2023;1327562.
Santos HO, Cadegiani FA, Forbes SC. Nonpharmacological interventions for the management of testosterone and sperm parameters: a scoping review. Clin Ther 2022;44:1129–49.
Sabzeie MM, Ayen E, Soleimanzadeh A, Bucak MN. Tribulus terrestris aqueous extract supplementation effects on sperm characteristics and anti-oxidant status during chilled storage of canine semen. Vet Res Forum 2023;14:71–7.
GamalEl Din SF. Role of Tribulus terrestris in male infertility: is it real or fiction?. J Diet Suppl 2018;15:1010–3.
Qureshi A, Naughton DP, Petroczi A. A systematic review on the herbal extract Tribulus terrestris and the roots of its putative aphrodisiac and performance enhancing effect. J Diet Suppl 2014;11:64–79.
Baker ME. Endocrine activity of plant-derived compounds: an evolutionary perspective. Proc Soc Exp Biol Med 1995;208:131–8.
Yin L, Wang Q, Wang X, Song LN. Effects of Tribulus terrestris saponins on exercise performance in overtraining rats and the underlying mechanisms. Can J Physiol Pharmacol 2016;94:1193–201.
Ribeiro CT, De Souza DB, Costa WS, Pereira-Sampaio MA, Sampaio FJ. Effects of testicular transfixation on seminiferous tubule morphology and sperm parameters of prepubertal, pubertal, and adult rats. Theriogenology 2015;84:1142–8.
Scherle W. A simple method for volumetry of organs in quantitative stereology. Mikroskopie 1970;26:57–60.
Ribeiro CT, De Souza DB, Medeiros JL Jr, Costa WS, Pereira-Sampaio MA, et al. Pneumoperitoneum induces morphological alterations in the rat testicle. Acta Cir Bras 2013;28:419–22.
Ribeiro CT, De Souza DB, Costa WS, Sampaio FJ, Pereira-Sampaio MA. Immediate and late effects of chronic stress in the testes of prepubertal and adult rats. Asian J Androl 2018;20:385–90.
Ribeiro CT, Milhomem R, De Souza DB, Costa WS, Sampaio FJ, et al. Effect of antioxidants on outcome of testicular torsion in rats of different ages. J Urol 2014;191:1578–84.
Felix-Patrício B, De Souza DB, Gregório BM, Costa WS, Sampaio FJ. How to quantify penile corpus cavernosum structures with histomorphometry: comparison of two methods. Biomed Res Int 2015 2015;832156.
Nair AB, Jacob S. A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm 2016;7:27–31.
المشرفين على المادة: 0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20230911 Date Completed: 20240701 Latest Revision: 20240701
رمز التحديث: 20240701
مُعرف محوري في PubMed: PMC10846837
DOI: 10.4103/aja202340
PMID: 37695239
قاعدة البيانات: MEDLINE
الوصف
تدمد:1745-7262
DOI:10.4103/aja202340