دورية أكاديمية
Ionophores.
| العنوان: | Ionophores. |
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| المؤلفون: | Fritz SA; Department of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, 1620 Denison Avenue, 228 Coles Hall, Manhattan, KS 66506, USA. Electronic address: scottfritz@vet.k-state.edu., Hall JO; Cattle Technical Services, Huvepharma Inc., 525 Westpark Dr, Suite 230, Peachtree City, GA 30269, USA. |
| المصدر: | The Veterinary clinics of North America. Equine practice [Vet Clin North Am Equine Pract] 2024 Apr; Vol. 40 (1), pp. 161-166. Date of Electronic Publication: 2023 Sep 09. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders Country of Publication: United States NLM ID: 8511904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-4224 (Electronic) Linking ISSN: 07490739 NLM ISO Abbreviation: Vet Clin North Am Equine Pract Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia : W.B. Saunders, c1985- |
| مواضيع طبية MeSH: | Horse Diseases*, Humans ; Animals ; Horses ; Ionophores/pharmacology ; Diet |
| مستخلص: | Ionophores are a class of polyether antibiotics that are commonly used as anticoccidial agents and growth promotants in ruminant diets. Ionophores transport ions across lipid membranes and down concentration gradients, which results in mitochondrial destruction, reduced cellular energy production, and ultimately cell death. Cardiomyocytes are the primary target in equine patients when exposed to toxic concentrations and the clinical disease syndrome is related to myocardial damage. Animals can survive acute exposures but can have permanent heart damage that may result in acute death at future time points. Animals that survive a poisoning incident may live productive breeding lives, but physical performance can be greatly impacted. Animals with myocardial damage are at risk of sudden death and pose a risk to riders. Competing Interests: Disclosure The authors have no disclosures to make. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Heart failure; Horse; Ionophores; Monensin; Toxicity |
| المشرفين على المادة: | 0 (Ionophores) |
| تواريخ الأحداث: | Date Created: 20230911 Date Completed: 20240311 Latest Revision: 20240311 |
| رمز التحديث: | 20240311 |
| DOI: | 10.1016/j.cveq.2023.08.001 |
| PMID: | 37696707 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1558-4224 |
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| DOI: | 10.1016/j.cveq.2023.08.001 |