Long exposure to a mixture of endocrine disruptors prediposes the ventral prostate of rats to preneoplastic lesions.

التفاصيل البيبلوغرافية
العنوان:	Long exposure to a mixture of endocrine disruptors prediposes the ventral prostate of rats to preneoplastic lesions.
المؤلفون:	Sousa TC; Graduate Program in Animal Science, Western São Paulo University (UNOESTE), Rodovia Raposo Tavares, Km 572 - Bairro Do Limoeiro, Presidente Prudente, SP, Brazil., de Souza LP; Faculty of Healthy Sciences, Western São Paulo University (UNOESTE), R. José Bongiovani, 700 - Cidade Universitária, Presidente Prudente, SP, Brazil., Ricardo MLS; Graduate Program in Animal Science, Western São Paulo University (UNOESTE), Rodovia Raposo Tavares, Km 572 - Bairro Do Limoeiro, Presidente Prudente, SP, Brazil., Yoshigae AY; Graduate Program in Animal Science, Western São Paulo University (UNOESTE), Rodovia Raposo Tavares, Km 572 - Bairro Do Limoeiro, Presidente Prudente, SP, Brazil., Hinokuma KD; Graduate Program in Animal Science, Western São Paulo University (UNOESTE), Rodovia Raposo Tavares, Km 572 - Bairro Do Limoeiro, Presidente Prudente, SP, Brazil., Gorzoni ABR; Graduate Program in Animal Science, Western São Paulo University (UNOESTE), Rodovia Raposo Tavares, Km 572 - Bairro Do Limoeiro, Presidente Prudente, SP, Brazil., de Aquino AM; Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, United States., Scarano WR; Department of Functional and Structural Biology, IBB/UNESP, Rubião Junior, Botucatu, SP, Brasil., de Sousa Castillho AC; Graduate Program in Animal Science, Western São Paulo University (UNOESTE), Rodovia Raposo Tavares, Km 572 - Bairro Do Limoeiro, Presidente Prudente, SP, Brazil., Tavares MEA; Experimental Laboratory of Exercise Biology (LEBioEx), São Paulo State University (UNESP), Presidente Prudente, SP, Brazil., Veras ASC; Experimental Laboratory of Exercise Biology (LEBioEx), São Paulo State University (UNESP), Presidente Prudente, SP, Brazil., Teixeira GR; Experimental Laboratory of Exercise Biology (LEBioEx), São Paulo State University (UNESP), Presidente Prudente, SP, Brazil., Nai GA; Graduate Program in Animal Science, Western São Paulo University (UNOESTE), Rodovia Raposo Tavares, Km 572 - Bairro Do Limoeiro, Presidente Prudente, SP, Brazil.; Graduate Program in Health Science, Western São Paulo University (UNOESTE), Rodovia Raposo Tavares, km 572 - Bairro do Limoeiro, Presidente Prudente, SP, CEP 19067-175, Brazil., de Oliveira Mendes L; Graduate Program in Animal Science, Western São Paulo University (UNOESTE), Rodovia Raposo Tavares, Km 572 - Bairro Do Limoeiro, Presidente Prudente, SP, Brazil. leobio85@gmail.com.; Graduate Program in Health Science, Western São Paulo University (UNOESTE), Rodovia Raposo Tavares, km 572 - Bairro do Limoeiro, Presidente Prudente, SP, CEP 19067-175, Brazil. leobio85@gmail.com.
المصدر:	Environmental science and pollution research international [Environ Sci Pollut Res Int] 2023 Oct; Vol. 30 (47), pp. 104015-104028. Date of Electronic Publication: 2023 Sep 11.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE
أسماء مطبوعة:	Publication: <2013->: Berlin : Springer Original Publication: Landsberg, Germany : Ecomed
مواضيع طبية MeSH:	Endocrine Disruptors*/toxicity, Humans ; Pregnancy ; Female ; Rats ; Animals ; Male ; Rats, Sprague-Dawley ; Prostate ; Corn Oil/pharmacology ; Hormones
مستخلص:	Endocrine disruptors (ED) are compounds dispersed in the environment that modify hormone biosynthesis, affecting hormone-dependent organs such as the prostate. Studies have only focused on evaluating the effects of ED alone or in small groups and short intervals and have not adequately portrayed human exposure. Therefore, we characterized the prostate histoarchitecture of rats exposed to an ED mixture (ED Mix) mimicking human exposure. Pregnant females of the Sprague-Dawley strain were randomly distributed into two experimental groups: Control group (vehicle: corn oil, by gavage) and ED Mix group: received 32.11 mg/kg/day of the ED mixture diluted in corn oil (2 ml/kg), by gavage, from gestational day 7 (DG7) to post-natal day 21 (DPN21). After weaning at DPN22, the male pups continued to receive the complete DE mixture until they were 220 days old when they were euthanized. The ED Mix decreased the epithelial compartment, increased the fractal dimension, and decreased glandular dilation. In addition, low-grade prostatic intraepithelial neoplasia was observed in addition to regions of epithelial atrophy in the group exposed to the ED Mix. Exposure to the mixture decreased both types I and III collagen area in the stroma. We concluded that the ED Mix was able to cause alterations in the prostatic histoarchitecture and induce the appearance of preneoplastic lesions. (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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معلومات مُعتمدة:	2018/24044-0 Fundação de Amparo à Pesquisa do Estado de São Paulo
فهرسة مساهمة:	Keywords: Collagen; Ecotoxicology; Endocrine disruptors; Environmental exposure; Prostate gland; Prostatic intraepithelial neoplasia
المشرفين على المادة:	0 (Endocrine Disruptors) 8001-30-7 (Corn Oil) 0 (Hormones)
تواريخ الأحداث:	Date Created: 20230911 Date Completed: 20231023 Latest Revision: 20231023
رمز التحديث:	20231215
DOI:	10.1007/s11356-023-29768-z
PMID:	37697193
قاعدة البيانات:	MEDLINE

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تدمد:	1614-7499
DOI:	10.1007/s11356-023-29768-z