دورية أكاديمية
Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first-pass skin metabolism of the hair dye, 4-amino-2-hydroxytoluene.
العنوان: | Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first-pass skin metabolism of the hair dye, 4-amino-2-hydroxytoluene. |
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المؤلفون: | Brandmair K; Beiersdorf AG, Unnastraße 48, D-20253, Hamburg, Germany., Tao TP; TissUse GmbH, Oudenarder Str. 16, D-13347, Berlin, Germany., Gerlach S; Beiersdorf AG, Unnastraße 48, D-20253, Hamburg, Germany., Przibilla J; Pharmacelsus GmbH, Science Park 2, D-66123, Saarbrücken, Germany., Schepky A; Beiersdorf AG, Unnastraße 48, D-20253, Hamburg, Germany., Marx U; TissUse GmbH, Oudenarder Str. 16, D-13347, Berlin, Germany., Hewitt NJ; Cosmetics Europe, Avenue Herrmann-Debroux 40, 1160, Auderghem, Belgium., Kühnl J; Beiersdorf AG, Unnastraße 48, D-20253, Hamburg, Germany., Maschmeyer I; TissUse GmbH, Oudenarder Str. 16, D-13347, Berlin, Germany. |
المصدر: | Journal of applied toxicology : JAT [J Appl Toxicol] 2024 Mar; Vol. 44 (3), pp. 333-343. Date of Electronic Publication: 2023 Sep 12. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: John Wiley And Sons Country of Publication: England NLM ID: 8109495 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1263 (Electronic) Linking ISSN: 0260437X NLM ISO Abbreviation: J Appl Toxicol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Original Publication: [Philadelphia, Pa. : Heyden & Son, c1981- |
مواضيع طبية MeSH: | Hair Dyes*/metabolism , Cresols*, Humans ; Skin/metabolism ; Aniline Compounds/metabolism ; Liver |
مستخلص: | The HUMIMIC skin-liver Chip2 microphysiological systems model using the epidermal model, EpiDerm™, was reported previously to mimic application route-dependent metabolism of the hair dye, 4-amino-2-hydroxytoluene (AHT). Therefore, we evaluated the use of alternative skin models-SkinEthic™, EpiDermFT™ and PhenionFT™-for the same purpose. In static incubations, AHT permeation was similar using SkinEthic™ and EpiDerm™ models. Older Day 21 (D21) SkinEthic™ models with a thicker stratum corneum did not exhibit a greater barrier to AHT (overall permeation was the same in D17 and D21 models). All epidermal models metabolised AHT, with the EpiDerm™ exhibiting higher N-acetylation than SkinEthic™ models. AHT metabolism by D21 SkinEthic™ models was lower than that by D17 SkinEthic™ and EpiDerm™ models, thus a thicker stratum corneum was associated with fewer viable cells and a lower metabolic activity. AHT permeation was much slower using PhenionFT™ compared to epidermal models and better reflected permeation of AHT through native human skin. This model also extensively metabolised AHT to N-acetyl-AHT. After a single topical or systemic application of AHT to Chip2 model with PhenionFT™, medium was analysed for parent and metabolites over 5 days. The first-pass metabolism of AHT was demonstrated, and the introduction of a wash step after 30 min decreased the exposure to AHT and its metabolites by 33% and 40%-43%, respectively. In conclusion, epidermal and FT skin models used in the Chip2 can mimic the first-pass skin metabolism of AHT. This highlights the flexibility of the Chip2 to incorporate different skin models according to the purpose. (© 2023 The Authors. Journal of Applied Toxicology published by John Wiley & Sons Ltd.) |
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معلومات مُعتمدة: | Cosmetics Europe Long Range Science Strategy programme |
فهرسة مساهمة: | Keywords: 4-amino-2-hydroxytoluene; Chip2; EpiDerm; EpiDermFT; PhenionFT; cosmetics; first-pass metabolism; microphysiological systems; skin; skin models |
المشرفين على المادة: | UBB8XEB10B (4-amino-2-hydroxytoluene) 0 (Hair Dyes) 0 (Aniline Compounds) 0 (Cresols) |
تواريخ الأحداث: | Date Created: 20230912 Date Completed: 20240214 Latest Revision: 20240520 |
رمز التحديث: | 20240520 |
DOI: | 10.1002/jat.4542 |
PMID: | 37699698 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1099-1263 |
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DOI: | 10.1002/jat.4542 |