دورية أكاديمية
Genetic differences in the effects of delta-aminolevulinic acid on seizure latency in mice.
| العنوان: | Genetic differences in the effects of delta-aminolevulinic acid on seizure latency in mice. |
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| المؤلفون: | Wehner JM, Marley RJ |
| المصدر: | Experimental neurology [Exp Neurol] 1986 Nov; Vol. 94 (2), pp. 280-91. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print Cited Medium: Print ISSN: 0014-4886 (Print) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Orlando Fl : Academic Press Original Publication: New York. |
| مواضيع طبية MeSH: | Aminolevulinic Acid/*pharmacology , Levulinic Acids/*pharmacology , Seizures/*metabolism , gamma-Aminobutyric Acid/*metabolism, Aminolevulinic Acid/administration & dosage ; Animals ; Injections, Intraperitoneal ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Seizures/chemically induced ; Seizures/genetics |
| مستخلص: | delta-Aminolevulinic acid, an intermediate in heme formation, is elevated in certain human disorders including acute intermittent porphyria, tyrosinemia, and lead poisoning. It has been implicated in the central nervous system manifestations of these disorders via interactions with the GABAergic system. This potential interaction was examined by testing whether or not delta-aminolevulinic acid could alter the latency to seizure in mice. Seizures were induced in a variety of inbred strains of mice including C57BL, C3H, DBA mice and in a heterogeneous stock of mice. Flurothyl and 3-mercaptopropionic acid were used to induce seizures in the presence and absence of delta-aminolevulinic acid administered either i.p. (0.5 and 1.5 mmol/kg), or i.c.v. (4.5 and 450 nmol). delta-Aminolevulinic acid increased the latency to myoclonic and clonic seizures induced by flurothyl when administered i.p.; i.c.v. injections also delayed clonic seizures induced by flurothyl, and increased the latency to tonic seizures induced by 3-mercaptopropionic acid. The degree to which delta-aminolevulinic acid altered seizure latency in all tests was dependent on strain of mouse tested. These data support the conclusion that delta-aminolevulinic acid can act as an anticonvulsant agent, and mimic the effects of GABA. Moreover, there is genetic variation in the sensitivity of the various strains of mice to delta-aminolevulinic acid. |
| معلومات مُعتمدة: | RR-07013-19 United States RR NCRR NIH HHS; RR-07013-20 United States RR NCRR NIH HHS |
| المشرفين على المادة: | 0 (Levulinic Acids) 56-12-2 (gamma-Aminobutyric Acid) 88755TAZ87 (Aminolevulinic Acid) |
| تواريخ الأحداث: | Date Created: 19861101 Date Completed: 19861202 Latest Revision: 20190722 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1016/0014-4886(86)90102-0 |
| PMID: | 3770119 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0014-4886 |
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| DOI: | 10.1016/0014-4886(86)90102-0 |