دورية أكاديمية
Platelet status in cancer cachexia progression in Apc Min/+ mice.
| العنوان: | Platelet status in cancer cachexia progression in Apc Min/+ mice. |
|---|---|
| المؤلفون: | Cunningham P; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Unger CA; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Patton EA; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Aiken A; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States.; Columbia Department of Veterans Affairs Health Care System, Columbia, SC, United States., Browne A; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., James E; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Aladhami AK; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Hope Rd MC; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., VanderVeen BN; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Cardaci TD; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Murphy EA; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Enos RT; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Velázquez KT; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States.; Columbia Department of Veterans Affairs Health Care System, Columbia, SC, United States. |
| المصدر: | Frontiers in immunology [Front Immunol] 2023 Aug 28; Vol. 14, pp. 1253587. Date of Electronic Publication: 2023 Aug 28 (Print Publication: 2023). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Blood Platelets* , Colonic Neoplasms*, Animals ; Mice ; Cachexia/etiology ; Quality of Life ; Disease Models, Animal |
| مستخلص: | Cachexia, a complex wasting syndrome, significantly affects the quality of life and treatment options for cancer patients. Studies have reported a strong correlation between high platelet count and decreased survival in cachectic individuals. Therefore, this study aimed to investigate the immunopathogenesis of cancer cachexia using the Apc Min/+ mouse model of spontaneous colorectal cancer. The research focused on identifying cellular elements in the blood at different stages of cancer cachexia, assessing inflammatory markers and fibrogenic factors in the skeletal muscle, and studying the behavioral and metabolic phenotype of Apc Min/+ mice at the pre-cachectic and severely cachectic stages. Platelet measurements were also obtained from other animal models of cancer cachexia - Lewis Lung Carcinoma and Colon 26 adenocarcinoma. Our study revealed that platelet number is elevated prior to cachexia development in Apc Min/+ mice and can become activated during its progression. We also observed increased expression of TGFβ2, TGFβ3, and SMAD3 in the skeletal muscle of pre-cachectic Apc Min/+ mice. In severely cachectic mice, we observed an increase in Ly6g, CD206, and IL-10 mRNA. Meanwhile, IL-1β gene expression was elevated in the pre-cachectic stage. Our behavioral and metabolic phenotyping results indicate that pre-cachectic Apc Min/+ mice exhibit decreased physical activity. Additionally, we found an increase in anemia at pre-cachectic and severely cachectic stages. These findings highlight the altered platelet status during early and late stages of cachexia and provide a basis for further investigation of platelets in the field of cancer cachexia. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Cunningham, Unger, Patton, Aiken, Browne, James, Aladhami, Hope 3rd, VanderVeen, Cardaci, Murphy, Enos and Velázquez.) |
| References: | N Engl J Med. 2012 Feb 16;366(7):610-8. (PMID: 22335738) Nat Rev Immunol. 2011 Apr;11(4):264-74. (PMID: 21436837) J Med Econ. 2016 Sep;19(9):874-80. (PMID: 27100202) Br J Haematol. 1982 Mar;50(3):509-19. (PMID: 7066203) J Surg Oncol. 2012 Dec;106(7):887-91. (PMID: 22623286) JNCI Cancer Spectr. 2018 Jul;2(3):pky043. (PMID: 30637373) Crit Rev Oncol Hematol. 2023 Jun;186:103989. (PMID: 37061076) PLoS One. 2022 Jun 23;17(6):e0270338. (PMID: 35737651) Curr Osteoporos Rep. 2020 Dec;18(6):646-654. (PMID: 33044689) Cancer Res. 2011 Mar 1;71(5):1710-20. (PMID: 21163868) Sci Adv. 2021 Sep 10;7(37):eabi4852. (PMID: 34516881) Front Immunol. 2023 Mar 15;14:1159411. (PMID: 37006254) J Pathol. 2012 Oct;228(2):251-9. (PMID: 22431140) Cancer Med. 2019 Jun;8(6):3314-3324. (PMID: 31074202) J Cell Biol. 1996 Jan;132(1-2):195-210. (PMID: 8567723) Sci Rep. 2020 May 5;10(1):7535. (PMID: 32371869) Front Oncol. 2021 Jul 12;11:665534. (PMID: 34322381) Muscle Nerve. 1999 Jul;22(7):889-98. (PMID: 10398207) Cancer. 1979 May;43(5 Suppl):2004-12. (PMID: 376104) Lab Invest. 2012 Aug;92(8):1100-14. (PMID: 22584670) Mayo Clin Proc. 2005 Jul;80(7):923-36. (PMID: 16007898) Support Care Cancer. 2016 Aug;24(8):3473-80. (PMID: 27003901) Shock. 2020 Jun;53(6):772-778. (PMID: 32413000) J Nutr. 1998 Aug;128(8):1355-60. (PMID: 9687556) J Hematol Oncol. 2023 Mar 27;16(1):30. (PMID: 36973755) Lancet Oncol. 2011 May;12(5):489-95. (PMID: 21296615) Clin Cancer Res. 2007 Nov 1;13(21):6379-85. (PMID: 17975150) Sci Transl Med. 2014 Dec 17;6(267):267ra176. (PMID: 25520397) Front Oncol. 2021 Dec 20;11:774347. (PMID: 34988017) J Am Med Dir Assoc. 2010 May;11(4):229-30. (PMID: 20439040) J Am Soc Nephrol. 1999 Jun;10(6):1264-73. (PMID: 10361864) Science. 1992 May 1;256(5057):668-70. (PMID: 1350108) J Urol. 2006 Mar;175(3 Pt 1):859-63. (PMID: 16469566) J Cell Biol. 2001 Aug 6;154(3):485-90. (PMID: 11489912) Drugs Context. 2014 Jul 31;3:212265. (PMID: 25126097) Pancreas. 2017 Oct;46(9):1152-1157. (PMID: 28902785) Nat Commun. 2020 May 5;11(1):2212. (PMID: 32371889) Anat Embryol (Berl). 1997 Jul;196(1):1-11. (PMID: 9242884) J Thromb Haemost. 2003 Sep;1(9):1897-905. (PMID: 12941029) Support Care Cancer. 2015 Jan;23(1):79-86. (PMID: 24975045) Cells. 2022 Jun 10;11(12):. (PMID: 35741022) Am J Respir Crit Care Med. 2006 Mar 1;173(5):483-90. (PMID: 16339920) Biochim Biophys Acta. 2011 Dec;1812(12):1601-6. (PMID: 21914473) Cytokine Growth Factor Rev. 2011 Aug;22(4):189-95. (PMID: 22019906) Cell Biochem Funct. 2023 Jun;41(4):478-489. (PMID: 37150891) Front Endocrinol (Lausanne). 2019 Nov 01;10:720. (PMID: 31736871) Thromb Haemost. 2003 Jun;89(6):1098-106. (PMID: 12783124) J Neuroimmunol. 1995 Dec;63(1):9-16. (PMID: 8557829) Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10729-32. (PMID: 1438269) Dig Liver Dis. 2016 Mar;48(3):327-32. (PMID: 26776879) Neuromuscul Disord. 2019 Jul;29(7):487-496. (PMID: 31326192) Thromb Res. 2018 Jun;166:28-36. (PMID: 29655000) Int J Cardiol. 2008 Oct 13;129(3):363-7. (PMID: 18022259) J Exp Med. 2009 Aug 31;206(9):1913-27. (PMID: 19667060) Nutrition. 1996 May;12(5):358-71. (PMID: 8875522) J Thromb Haemost. 2017 Mar;15(3):477-486. (PMID: 28058802) Ann Palliat Med. 2019 Jan;8(1):67-79. (PMID: 30180740) Support Care Cancer. 2011 Sep;19(9):1451-63. (PMID: 20714754) Transfus Med. 2001 Dec;11(6):403-17. (PMID: 11851938) Front Oncol. 2021 Mar 17;11:642170. (PMID: 33816291) Biochim Biophys Acta. 2015 May;1852(5):816-25. (PMID: 25555992) Nutrition. 2005 Sep;21(9):977-85. (PMID: 16043325) Nat Med. 2015 Nov;21(11):1262-1271. (PMID: 26457758) Front Oncol. 2020 Jan 29;10:39. (PMID: 32083001) Front Mol Neurosci. 2020 Feb 04;13:3. (PMID: 32116541) Br J Cancer. 1993 May;67(5):939-44. (PMID: 8494727) J Cachexia Sarcopenia Muscle. 2012 Jun;3(2):117-37. (PMID: 22476915) Eur Respir J. 1996 Sep;9(9):1826-30. (PMID: 8880098) Endocrinology. 1991 May;128(5):2657-9. (PMID: 2019273) J Cancer. 2021 Oct 30;12(24):7436-7444. (PMID: 35003363) Med Sci Sports Exerc. 2020 Nov;52(11):2320-2330. (PMID: 33064407) Cytokine. 2005 Dec 7;32(5):234-9. (PMID: 16338141) Blood Adv. 2016 Nov 22;1(1):5-9. (PMID: 29296690) JAMA Netw Open. 2022 Jan 4;5(1):e2141633. (PMID: 35015064) Cancer Epidemiol Biomarkers Prev. 2003 May;12(5):391-400. (PMID: 12750232) Muscle Nerve. 2008 Feb;37(2):190-5. (PMID: 17912749) Br J Cancer. 2016 Mar 15;114(6):680-7. (PMID: 26954714) Transfus Med Rev. 2020 Oct;34(4):209-220. (PMID: 33051111) Elife. 2021 Nov 02;10:. (PMID: 34726154) Mol Cell Proteomics. 2017 Jan;16(1):86-99. (PMID: 27879288) J Cachexia Sarcopenia Muscle. 2012 Dec;3(4):245-51. (PMID: 22648739) BMC Cancer. 2007 Mar 14;7:45. (PMID: 17359523) Blood. 2001 Nov 1;98(9):2720-5. (PMID: 11675343) J Appl Physiol (1985). 2010 Oct;109(4):1155-61. (PMID: 20651218) BMC Cancer. 2017 Feb 16;17(1):141. (PMID: 28209123) Front Oncol. 2021 Mar 15;11:642761. (PMID: 33791226) Physiol Rep. 2021 Jul;9(14):e14924. (PMID: 34270178) J Immunol. 2015 Jun 15;194(12):5579-87. (PMID: 26048965) Cancer Lett. 1994 Apr 29;79(1):83-9. (PMID: 8187058) Am J Clin Nutr. 2011 Sep;94(3):945-54. (PMID: 21813809) J Cell Physiol. 2004 Apr;199(1):67-76. (PMID: 14978736) Med Sci Sports Exerc. 2022 Jan 1;54(1):77-88. (PMID: 34431825) Thromb Haemost. 2015 Aug 31;114(3):449-58. (PMID: 26293514) Asian Pac J Cancer Prev. 2014;15(15):6421-3. (PMID: 25124636) Pflugers Arch. 2009 Mar;457(5):989-1001. (PMID: 18712412) Cancers (Basel). 2021 Mar 20;13(6):. (PMID: 33804721) Am J Physiol Endocrinol Metab. 2017 May 1;312(5):E447-E459. (PMID: 28292759) Sci Rep. 2021 Nov 3;11(1):21563. (PMID: 34732809) Mol Cell Biol. 1995 Jan;15(1):58-68. (PMID: 7799967) |
| معلومات مُعتمدة: | T34 GM136495 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: TGFβ; muscle wasting; physical activity; platelets; red blood cells |
| تواريخ الأحداث: | Date Created: 20230913 Date Completed: 20230914 Latest Revision: 20240815 |
| رمز التحديث: | 20240815 |
| مُعرف محوري في PubMed: | PMC10493779 |
| DOI: | 10.3389/fimmu.2023.1253587 |
| PMID: | 37701438 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-3224 |
|---|---|
| DOI: | 10.3389/fimmu.2023.1253587 |