دورية أكاديمية
Pythium insidiosum: insights into biofilm formation and antibiofilm activity of antifungal drugs.
| العنوان: | Pythium insidiosum: insights into biofilm formation and antibiofilm activity of antifungal drugs. |
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| المؤلفون: | Pippi B; Graduation Program in Pharmacology, Federal University of Santa Maria, Santa Maria, RS, Brazil., Loreto ES; Sobresp Faculty of Health Sciences, Santa Maria, RS, Brazil., Merkel S; Graduation Program in Biological Sciences: Pharmacology and Therapeutics, Department of Pharmacology, Basic Health Sciences Institute, Federal University of Rio Grande Do Sul, 2600 Ramiro Barcelos Street, Porto Alegre, RS, 90035-003, Brazil., Joaquim AR; Graduation Program in Pharmaceutical Sciences, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil., Krummenauer ME; Biotechnology Center, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil., Reginatto P; Graduation Program in Pharmaceutical Sciences, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil., Vainstein MH; Biotechnology Center, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil., Andrade SF; Graduation Program in Pharmaceutical Sciences, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil., Fuentefria AM; Graduation Program in Biological Sciences: Pharmacology and Therapeutics, Department of Pharmacology, Basic Health Sciences Institute, Federal University of Rio Grande Do Sul, 2600 Ramiro Barcelos Street, Porto Alegre, RS, 90035-003, Brazil.; Graduation Program in Pharmaceutical Sciences, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil., Santurio JM; Graduation Program in Pharmacology, Federal University of Santa Maria, Santa Maria, RS, Brazil., Zanette RA; Graduation Program in Biological Sciences: Pharmacology and Therapeutics, Department of Pharmacology, Basic Health Sciences Institute, Federal University of Rio Grande Do Sul, 2600 Ramiro Barcelos Street, Porto Alegre, RS, 90035-003, Brazil. regnitro@yahoo.com.br. |
| المصدر: | Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2023 Dec; Vol. 54 (4), pp. 2603-2607. Date of Electronic Publication: 2023 Sep 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Publishing Country of Publication: Brazil NLM ID: 101095924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4405 (Electronic) Linking ISSN: 15178382 NLM ISO Abbreviation: Braz J Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2019- : Switzerland, AG : Springer International Publishing Original Publication: Rio de Janeiro, RJ, Brasil : Sociedade Brasileira de Microbiologia |
| مواضيع طبية MeSH: | Pythium* , Pythiosis*/drug therapy , Pythiosis*/microbiology, Animals ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use |
| مستخلص: | In this study, we investigate the ability of Pythium insidiosum to form biofilms across various substrates and the antibiofilm efficacy of 8-hydroxyquinoline derivatives (8-HQs). Biofilms of P. insidiosum were cultured on polystyrene plates, contact lenses, and horsehair. We provide the first evidence of P. insidiosum's biofilm-forming capability, thus considerably expanding our understanding of its transmission and pathogenesis. Our results demonstrate that 8-HQs effectively inhibit biofilm formation and eradicate pre-existing biofilms, underscoring their potential as a novel treatment strategy for pythiosis, a disease currently lacking a gold-standard treatment. This finding has particular relevance for ocular pythiosis associated with contact lens usage and potential infection sources in animals. Our results contribute to the scientific knowledge base and directly impact innovative therapeutic interventions' development. (© 2023. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.) |
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| فهرسة مساهمة: | Keywords: 8-Hydroxyquinoline; Antimicrobial resistance; Biofilm formation; Clioquinol; Pythium insidiosum |
| المشرفين على المادة: | 0 (Antifungal Agents) |
| تواريخ الأحداث: | Date Created: 20230913 Date Completed: 20231204 Latest Revision: 20231205 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10689302 |
| DOI: | 10.1007/s42770-023-01123-x |
| PMID: | 37702922 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1678-4405 |
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| DOI: | 10.1007/s42770-023-01123-x |