دورية أكاديمية
Adrenal function in relation to cytokines and outcome in non-critically ill patients with COVID-19.
| العنوان: | Adrenal function in relation to cytokines and outcome in non-critically ill patients with COVID-19. |
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| المؤلفون: | Athanasiou N; First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece., Diamantopoulos A; Department of Endocrinology Diabetes and Metabolism, National and European Expertise Center for Rare Endocrine Diseases, Evangelismos Hospital, Athens, Greece., Keskinidou C; First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece., Katsaounou P; First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece., Angelousi A; First Department of Internal Medicine, Unit of Endocrinology, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece., Jahaj E; First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece., Mourelatos P; Department of Endocrinology Diabetes and Metabolism, National and European Expertise Center for Rare Endocrine Diseases, Evangelismos Hospital, Athens, Greece., Vrettou CS; First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece., Botoula E; Department of Endocrinology Diabetes and Metabolism, National and European Expertise Center for Rare Endocrine Diseases, Evangelismos Hospital, Athens, Greece., Vassiliou AG; First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece., Kotanidou A; First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece., Tsagarakis S; Department of Endocrinology Diabetes and Metabolism, National and European Expertise Center for Rare Endocrine Diseases, Evangelismos Hospital, Athens, Greece., Dimopoulou I; First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece., Vassiliadi DA; Department of Endocrinology Diabetes and Metabolism, National and European Expertise Center for Rare Endocrine Diseases, Evangelismos Hospital, Athens, Greece. dimitra.vas@gmail.com. |
| المصدر: | Journal of endocrinological investigation [J Endocrinol Invest] 2024 Mar; Vol. 47 (3), pp. 721-728. Date of Electronic Publication: 2023 Sep 13. |
| نوع المنشور: | Observational Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Italy NLM ID: 7806594 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1720-8386 (Electronic) Linking ISSN: 03914097 NLM ISO Abbreviation: J Endocrinol Invest Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Berlin : Springer Original Publication: Milano, Published for the Italian Society of Endocrinology by Editrice Kurtis. |
| مواضيع طبية MeSH: | Cytokines* , COVID-19*, Humans ; Hydrocortisone ; Hypothalamo-Hypophyseal System ; Interleukin-6 ; Pituitary-Adrenal System ; SARS-CoV-2 ; Adrenocorticotropic Hormone |
| مستخلص: | Purpose: We aimed to identify whether hypothalamic-pituitary-adrenal (HPA) axis dysfunction is related to deterioration in a percentage of patients who progress to severe COVID-19. Methods: In this cohort observational study, we evaluated HPA axis activation by measuring cortisol, adrenocorticotropic hormone (ACTH), dehydroepiandrosterone sulfate (DHEA-S) levels, whole blood expression levels of the key glucocorticoid receptor, GCR-α, and the glucocorticoid-induced leucine zipper (GILZ), and cytokines, as markers of the inflammatory phase, in 149 patients with respiratory infection admitted in the ward, without known adrenal disease and/or confounding medications (glucocorticoids). One hundred and four (104) patients were SARS-CoV-2 positive (C +) and controls consisted of 45 SARS-CoV-2-negative patients (NC). Results: No differences in cortisol levels were observed between the C + and the NC patients. Cortisol levels correlated with ACTH (r = 0.284, p = 0.001) and IL-6 (r = 0.289, p = 0.04). In C + patients, cortisol levels mainly correlated with IL-6 levels (r = 0.28; p = 0.017). GCR-α expression was significantly higher in C + patients compared to NC. Patients with higher cortisol levels were more likely to progress to respiratory function deterioration or die. Both GCR-α and GILZ expression were significantly higher in C + non-survivors. Conclusion: Our findings indicate that cortisol serves as an indicator of disease severity. GILZ expression appears to be a more effective marker of mortality prediction in moderate COVID-19 cases. However, routine measurement of GILZ levels is currently unavailable. Elevated levels of cortisol may be indicative of patients with moderate COVID-19 who are at a higher risk of deterioration. This information can aid in identifying individuals who require early medical attention. (© 2023. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).) |
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| فهرسة مساهمة: | Keywords: Adrenal; COVID-19; Cortisol; GILZ, GCR-α; IL-6; SARS-CoV-2 |
| المشرفين على المادة: | 0 (Cytokines) WI4X0X7BPJ (Hydrocortisone) 0 (Interleukin-6) 9002-60-2 (Adrenocorticotropic Hormone) |
| تواريخ الأحداث: | Date Created: 20230913 Date Completed: 20240304 Latest Revision: 20240609 |
| رمز التحديث: | 20240610 |
| DOI: | 10.1007/s40618-023-02189-y |
| PMID: | 37702927 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1720-8386 |
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| DOI: | 10.1007/s40618-023-02189-y |