دورية أكاديمية
Cellular Blood Flow Modeling with HemoCell.
العنوان: | Cellular Blood Flow Modeling with HemoCell. |
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المؤلفون: | Zavodszky G; University of Amsterdam, Amsterdam, Netherlands. g.zavodszky@uva.nl., Spieker C; University of Amsterdam, Amsterdam, Netherlands., Czaja B; SURF Cooperation, Amsterdam, The Netherlands., van Rooij B; Philips Medical Systems, Best, The Netherlands. |
المصدر: | Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2716, pp. 351-368. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Totowa, NJ : Humana Press Original Publication: Clifton, N.J. : Humana Press, |
مواضيع طبية MeSH: | Erythrocytes* , Glass*, Humans ; Computer Simulation ; Kidney Tubules ; Rheology |
مستخلص: | Many of the intriguing properties of blood originate from its cellular nature. Bulk effects, such as viscosity, depend on the local shear rates and on the size of the vessels. While empirical descriptions of bulk rheology are available for decades, their validity is limited to the experimental conditions they were observed under. These are typically artificial scenarios (e.g., perfectly straight glass tube or in pure shear with no gradients). Such conditions make experimental measurements simpler; however, they do not exist in real systems (i.e., in a real human circulatory system). Therefore, as we strive to increase our understanding on the cardiovascular system and improve the accuracy of our computational predictions, we need to incorporate a more comprehensive description of the cellular nature of blood. This, however, presents several computational challenges that can only be addressed by high performance computing. In this chapter, we describe HemoCell ( https://www.hemocell.eu ), an open-source high-performance cellular blood flow simulation, which implements validated mechanical models for red blood cells and is capable of reproducing the emergent transport characteristics of such a complex cellular system. We discuss the accuracy and the range of validity, and demonstrate applications on a series of human diseases. (© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.) |
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فهرسة مساهمة: | Keywords: Blood rheology; Cellular Blood Simulation; Computational Fluid Dynamics; High-Performance Computation; Immersed Boundary Method; Lattice Boltzmann method; Microfluidics |
تواريخ الأحداث: | Date Created: 20230913 Date Completed: 20230914 Latest Revision: 20230916 |
رمز التحديث: | 20240628 |
DOI: | 10.1007/978-1-0716-3449-3_16 |
PMID: | 37702948 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1940-6029 |
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DOI: | 10.1007/978-1-0716-3449-3_16 |