دورية أكاديمية
Detection of plasma anti-lipopolysaccharide (LPS) antibodies against enterohemorrhagic Escherichia coli (EHEC) in asymptomatic kindergarten teachers from Buenos Aires province.
| العنوان: | Detection of plasma anti-lipopolysaccharide (LPS) antibodies against enterohemorrhagic Escherichia coli (EHEC) in asymptomatic kindergarten teachers from Buenos Aires province. |
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| المؤلفون: | Fernandez-Brando RJ; Laboratorio de Patogénesis e Inmunología de Procesos Infecciosos, Instituto de Medicina Experimental (IMEX)-CONICET, Academia Nacional de Medicina, J.A. Pacheo de Melo 3081, C1425 CABA, Argentina., Sacerdoti F; Laboratorio de Fisiopatogenia, IFIBIO-Houssay (UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, C1121 CABA, Argentina., Amaral MM; Laboratorio de Fisiopatogenia, IFIBIO-Houssay (UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, C1121 CABA, Argentina., Bernal AM; Laboratorio de Patogénesis e Inmunología de Procesos Infecciosos, Instituto de Medicina Experimental (IMEX)-CONICET, Academia Nacional de Medicina, J.A. Pacheo de Melo 3081, C1425 CABA, Argentina., Da Rocha M; Asociación Lucha contra el Síndrome Urémico Hemolítico (LUSUH), Carlos Pellegrini 781 Piso 8, C1009 CABA, Argentina., Belardo M; Instituto de Estudios Sociales en Contexto de Desigualdades (IESCODE-CONICET), Universidad Nacional de José C. Paz, Leandro N. Alem 4731, B1665, José C. Paz, Buenos Aires, Argentina., Palermo MS; Laboratorio de Patogénesis e Inmunología de Procesos Infecciosos, Instituto de Medicina Experimental (IMEX)-CONICET, Academia Nacional de Medicina, J.A. Pacheo de Melo 3081, C1425 CABA, Argentina. Electronic address: mspalermo@hematologia.anm.edu.ar., Ibarra CA; Laboratorio de Fisiopatogenia, IFIBIO-Houssay (UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, C1121 CABA, Argentina. Electronic address: cristinaadrianaibarra@gmail.com. |
| المصدر: | Revista Argentina de microbiologia [Rev Argent Microbiol] 2024 Jan-Mar; Vol. 56 (1), pp. 25-32. Date of Electronic Publication: 2023 Sep 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Asociación Argentina de Microbiología Country of Publication: Argentina NLM ID: 8002834 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0325-7541 (Print) Linking ISSN: 03257541 NLM ISO Abbreviation: Rev Argent Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Buenos Aires, Asociación Argentina de Microbiología. |
| مواضيع طبية MeSH: | Enterohemorrhagic Escherichia coli* , Escherichia coli Infections*/epidemiology , Hemolytic-Uremic Syndrome*/epidemiology, Child ; Adult ; Humans ; Child, Preschool ; Lipopolysaccharides ; Diarrhea/epidemiology ; Immunoglobulin G ; Immunoglobulin M |
| مستخلص: | In Argentina, hemolytic uremic syndrome (HUS) caused by EHEC has the highest incidence in the world. EHEC infection has an endemo-epidemic behavior, causing 20-30% of acute bloody diarrhea syndrome in children under 5 years old. In the period 2016-2020, 272 new cases per year were notified to the National Health Surveillance System. Multiple factors are responsible for HUS incidence in Argentina including person-to-person transmission. In order to detect possible EHEC carriers, we carried out a preliminary study of the frequency of kindergarten teachers with anti-LPS antibodies against the most prevalent EHEC serotypes in Argentina. We analyzed 61 kindergarten teachers from 26 institutions from José C. Paz district, located in the suburban area of Buenos Aires province, Argentina. Fifty-one percent of the plasma samples had antibodies against O157, O145, O121 and O103 LPS: 6.4% of the positive samples had IgM isotype (n=2), 61.3% IgG isotype (n=19) and 32.3% IgM and IgG (n=10). Given that antibodies against LPS antigens are usually short-lived specific IgM detection may indicate a recent infection. In addition, the high percentage of positive samples may indicate a frequent exposure to EHEC strains in the cohort studied, as well as the existence of a large non-symptomatic population of adults carrying pathogenic strains that could contribute to the endemic behavior through person-to-person transmission. The improvement of continuous educational programs in kindergarten institutions could be a mandatory measure to reduce HUS cases not only in Argentina but also globally. (Copyright © 2023 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anti-LPS antibodies; Anticuerpos antilipopolisacáridos; Asymptomatic kindergarten teachers; Buenos Aires province; EHEC; Escherichia coli enterohemorrágica; Maestras y maestros asintomáticos de jardines de infantes; Provincia de Buenos Aires |
| المشرفين على المادة: | 0 (Lipopolysaccharides) 0 (Immunoglobulin G) 0 (Immunoglobulin M) |
| تواريخ الأحداث: | Date Created: 20230913 Date Completed: 20240320 Latest Revision: 20240320 |
| رمز التحديث: | 20240320 |
| DOI: | 10.1016/j.ram.2023.05.006 |
| PMID: | 37704516 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0325-7541 |
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| DOI: | 10.1016/j.ram.2023.05.006 |