دورية أكاديمية
Misoprostol-Induced Fever and Unnecessary Antibiotic Prescribing: A Retrospective Study.
| العنوان: | Misoprostol-Induced Fever and Unnecessary Antibiotic Prescribing: A Retrospective Study. |
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| المؤلفون: | Abu Esba LC; King Abdulaziz Medical City, Ministry of National Guard, Health Affairs, Riyadh, Saudi Arabia. abuesbala@ngha.med.sa.; King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. abuesbala@ngha.med.sa.; King Abdullah International Medical Research Centre, Riyadh, Kingdom of Saudi Arabia. abuesbala@ngha.med.sa., Al Mardawi G; King Abdulaziz Medical City, Ministry of National Guard, Health Affairs, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Centre, Riyadh, Kingdom of Saudi Arabia., Al Mardawi E; Department of Obstetric and Gynecology, Security Forces Hospital, Riyadh, Saudi Arabia., Almadhi FM; King Abdulaziz Medical City, Ministry of National Guard, Health Affairs, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Centre, Riyadh, Kingdom of Saudi Arabia., Ardah HI; King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.; Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. |
| المصدر: | Infectious diseases and therapy [Infect Dis Ther] 2023 Sep; Vol. 12 (9), pp. 2259-2268. Date of Electronic Publication: 2023 Sep 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Adis Country of Publication: New Zealand NLM ID: 101634499 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2193-8229 (Print) Linking ISSN: 21936382 NLM ISO Abbreviation: Infect Dis Ther Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : [Auckland] Adis Original Publication: [London] : Springer Healthcare |
| مستخلص: | Introduction: Misoprostol is widely used for medication abortion and postpartum hemorrhage. However, it has been associated with the adverse effect of fever, which can pose challenges in management and potentially contribute to unnecessary antibiotic use. The incidence of misoprostol-induced fever in the context of medical abortion has not been extensively studied. Methods: This retrospective cohort study aimed to determine the incidence of fever following misoprostol administration at a tertiary care hospital in Saudi Arabia. The study included female patients who received misoprostol for pregnancy termination or management of missed or incomplete abortion between January 2017 and December 2019. Data on demographics, misoprostol dosage and route, fever characteristics, outcome of abortion, and antibiotic use were collected. Statistical analysis was preformed using appropriate tests. Results: A total of 213 patients were included in the study. The incidence of fever post-misoprostol administration was 8%. Patients who developed fever had a higher gestational age and received higher doses of misoprostol. However, no significant associations were found between other patient variables and fever incidence. Antibiotic therapy was administered to a almost half of the patients who developed fever post-misoprostol but was determined to be unnecessary in all cases. Conclusion: This study contributes to the understanding of misoprostol-induced fever in the context of medical abortion. Further research is needed to explore strategies for reducing unnecessary antibiotic use in this population. (© 2023. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Abortion; Antimicrobial stewardship; Drug-induced fever; Medical abortion; Misoprostol; Misoprostol-induced fever; Missed abortion; Unnecessary antibiotic |
| تواريخ الأحداث: | Date Created: 20230913 Latest Revision: 20231020 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10581965 |
| DOI: | 10.1007/s40121-023-00865-3 |
| PMID: | 37704800 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2193-8229 |
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| DOI: | 10.1007/s40121-023-00865-3 |