دورية أكاديمية
Sector-Based Regression Strategies to Reduce Refractive Error-Associated Glaucoma Diagnostic Bias When Using OCT and OCT Angiography.
العنوان: | Sector-Based Regression Strategies to Reduce Refractive Error-Associated Glaucoma Diagnostic Bias When Using OCT and OCT Angiography. |
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المؤلفون: | Liu K; Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA.; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA., You QS; Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA., Chen A; Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA., Choi D; Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA., White E; Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA., Chan JCH; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong., Choy BNK; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong., Shih KC; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong., Wong JKW; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong., Ng ALK; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong., Cheung JJC; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong., Ni MY; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.; The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong.; Healthy High Density Cities Lab, HKUrbanLab, The University of Hong Kong, Hong Kong., Lai JSM; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong., Leung GM; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong., Wong IYH; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.; Department of Ophthalmology, Hong Kong Sanatorium & Hospital, Hong Kong., Huang D; Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA., Tan O; Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA. |
المصدر: | Translational vision science & technology [Transl Vis Sci Technol] 2023 Sep 01; Vol. 12 (9), pp. 10. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Association for Research in Vision and Ophthalmology Country of Publication: United States NLM ID: 101595919 Publication Model: Print Cited Medium: Internet ISSN: 2164-2591 (Electronic) Linking ISSN: 21642591 NLM ISO Abbreviation: Transl Vis Sci Technol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Rockville, Md. : Association for Research in Vision and Ophthalmology |
مواضيع طبية MeSH: | Refractive Errors*/diagnosis , Glaucoma*/diagnosis , Myopia*, Humans ; Tomography, Optical Coherence ; Cross-Sectional Studies ; Angiography |
مستخلص: | Purpose: This cross-sectional study aimed to investigate the sectoral variance of optical coherence tomography (OCT) and OCT angiography (OCTA) glaucoma diagnostic parameters across eyes with varying degrees of refractive error. Methods: Healthy participants, including individuals with axial ametropia, enrolled in the Hong Kong FAMILY cohort were imaged using the Avanti/AngioVue OCT/OCTA system. The OCT and OCTA parameters obtained include peripapillary nerve fiber layer thickness (NFLT), peripapillary nerve fiber layer plexus capillary density (NFLP-CD), and macular ganglion cell complex thickness (GCCT). Sectoral measurements of NFLT, NFLP-CD, and GCCT were based on sectors and hemispheres. Results: A total of 1339 eyes from 791 participants were stratified based on spherical equivalent refraction: high myopia (<-6 D), low myopia (-6 D to -1 D), emmetropia (-1 D to 1 D), and hyperopia (>1 D). Multivariable broken stick regression models, accounting for age, sex, and signal strength, showed that all NFLT sectors except temporally, the inferior GCCT hemisphere, and half of the NFLP-CD sectors were more affected by ametropia-related covariates than the corresponding global parameters. As expected, the false-positive rates in those sectors were elevated. Finally, sector-specific axial length (AL) and spherical equivalent (SE) adjustments helped reduce the elevated false-positive rates. Conclusions: The effect of optical magnification is even more prominent among sectors than the global parameters. AL- and SE-based adjustments should be individualized to each sector to mitigate this magnification bias effectively. Translational Relevance: Identifying sectoral differences among diagnostic parameters and adopting these sector-based adjustments into commercial OCT systems will hopefully reduce false-positive rates related to refractive error. |
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معلومات مُعتمدة: | R01 EY023285 United States EY NEI NIH HHS; R21 EY032146 United States EY NEI NIH HHS; P30 EY010572 United States EY NEI NIH HHS |
تواريخ الأحداث: | Date Created: 20230915 Date Completed: 20230918 Latest Revision: 20240413 |
رمز التحديث: | 20240413 |
مُعرف محوري في PubMed: | PMC10506684 |
DOI: | 10.1167/tvst.12.9.10 |
PMID: | 37713187 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2164-2591 |
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DOI: | 10.1167/tvst.12.9.10 |