دورية أكاديمية
أعرض في EDS

Sector-Based Regression Strategies to Reduce Refractive Error-Associated Glaucoma Diagnostic Bias When Using OCT and OCT Angiography.

التفاصيل البيبلوغرافية
العنوان: Sector-Based Regression Strategies to Reduce Refractive Error-Associated Glaucoma Diagnostic Bias When Using OCT and OCT Angiography.
المؤلفون: Liu K; Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA.; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA., You QS; Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA., Chen A; Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA., Choi D; Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA., White E; Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA., Chan JCH; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong., Choy BNK; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong., Shih KC; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong., Wong JKW; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong., Ng ALK; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong., Cheung JJC; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong., Ni MY; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.; The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong.; Healthy High Density Cities Lab, HKUrbanLab, The University of Hong Kong, Hong Kong., Lai JSM; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong., Leung GM; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong., Wong IYH; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.; Department of Ophthalmology, Hong Kong Sanatorium & Hospital, Hong Kong., Huang D; Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA., Tan O; Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA.
المصدر: Translational vision science & technology [Transl Vis Sci Technol] 2023 Sep 01; Vol. 12 (9), pp. 10.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Association for Research in Vision and Ophthalmology Country of Publication: United States NLM ID: 101595919 Publication Model: Print Cited Medium: Internet ISSN: 2164-2591 (Electronic) Linking ISSN: 21642591 NLM ISO Abbreviation: Transl Vis Sci Technol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Rockville, Md. : Association for Research in Vision and Ophthalmology
مواضيع طبية MeSH: Refractive Errors*/diagnosis , Glaucoma*/diagnosis , Myopia*, Humans ; Tomography, Optical Coherence ; Cross-Sectional Studies ; Angiography
مستخلص: Purpose: This cross-sectional study aimed to investigate the sectoral variance of optical coherence tomography (OCT) and OCT angiography (OCTA) glaucoma diagnostic parameters across eyes with varying degrees of refractive error.
Methods: Healthy participants, including individuals with axial ametropia, enrolled in the Hong Kong FAMILY cohort were imaged using the Avanti/AngioVue OCT/OCTA system. The OCT and OCTA parameters obtained include peripapillary nerve fiber layer thickness (NFLT), peripapillary nerve fiber layer plexus capillary density (NFLP-CD), and macular ganglion cell complex thickness (GCCT). Sectoral measurements of NFLT, NFLP-CD, and GCCT were based on sectors and hemispheres.
Results: A total of 1339 eyes from 791 participants were stratified based on spherical equivalent refraction: high myopia (<-6 D), low myopia (-6 D to -1 D), emmetropia (-1 D to 1 D), and hyperopia (>1 D). Multivariable broken stick regression models, accounting for age, sex, and signal strength, showed that all NFLT sectors except temporally, the inferior GCCT hemisphere, and half of the NFLP-CD sectors were more affected by ametropia-related covariates than the corresponding global parameters. As expected, the false-positive rates in those sectors were elevated. Finally, sector-specific axial length (AL) and spherical equivalent (SE) adjustments helped reduce the elevated false-positive rates.
Conclusions: The effect of optical magnification is even more prominent among sectors than the global parameters. AL- and SE-based adjustments should be individualized to each sector to mitigate this magnification bias effectively.
Translational Relevance: Identifying sectoral differences among diagnostic parameters and adopting these sector-based adjustments into commercial OCT systems will hopefully reduce false-positive rates related to refractive error.
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معلومات مُعتمدة: R01 EY023285 United States EY NEI NIH HHS; R21 EY032146 United States EY NEI NIH HHS; P30 EY010572 United States EY NEI NIH HHS
تواريخ الأحداث: Date Created: 20230915 Date Completed: 20230918 Latest Revision: 20240413
رمز التحديث: 20240413
مُعرف محوري في PubMed: PMC10506684
DOI: 10.1167/tvst.12.9.10
PMID: 37713187
قاعدة البيانات: MEDLINE
الوصف
تدمد:2164-2591
DOI:10.1167/tvst.12.9.10