دورية أكاديمية
أعرض في EDS

Gestational glucose intolerance and pregnancy outcomes: a retrospective study in the primary care setting of Macau.

التفاصيل البيبلوغرافية
العنوان: Gestational glucose intolerance and pregnancy outcomes: a retrospective study in the primary care setting of Macau.
المؤلفون: Lei SK; Seac Pai Van Health Center, Health Bureau, Macao SAR, China., Wong CL; Center for Disease Control and Prevention, Health Bureau, Macao SAR, China., Leung KP; Seac Pai Van Health Center, Health Bureau, Macao SAR, China., Shum TC; Seac Pai Van Health Center, Health Bureau, Macao SAR, China.
المصدر: Medicine [Medicine (Baltimore)] 2023 Sep 15; Vol. 102 (37), pp. e35175.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins
مواضيع طبية MeSH: Glucose Intolerance*/epidemiology , Hyperglycemia* , Diabetes, Gestational*/epidemiology, Pregnancy ; Infant ; Infant, Newborn ; Female ; Humans ; Retrospective Studies ; Cesarean Section ; Macau ; Glucose ; Primary Health Care
مستخلص: Although glucose intolerance is prevalent in Macau, it is rarely assessed during pregnancy. This study examined short-term maternal and neonatal outcomes at different maternal glucose levels in Macau. A total of 2388 pregnant women who received antenatal care at Health Centers and delivered at the Centro Hospitalar Conde de São Januário between June 2018 and December 2019 were included in this study. Gestational diabetes mellitus (GDM) was diagnosed using Carpenter and Coustan criteria, involving a 50 g glucose challenge test (GCT) followed by a 100g oral glucose tolerance test (OGTT). Participants were categorized into 4 groups: normal glucose tolerance if GCT was negative; mild gestational hyperglycemia in this study if positive GCT without GDM; GDM patients with normal fasting blood glucose (FBG) or high FBG in OGTT. Logistic regression analysis was employed to compare pregnancy outcomes among these 4 groups. Due to the limited number of cases, we combined several adverse maternal outcomes, including pregnancy-induced hypertension, assisted delivery, primary Caesarean section, moderate to severe perineal trauma, and postpartum hemorrhage, into a composite measure. The results showed higher rates of the aforementioned outcomes for mild gestational hyperglycemia and GDM with high FBG in OGTT groups [adjusted odds ratio (aOR) 1.32, 95% confidence interval (CI) 1.06-1.64; aOR 2.04, 95% CI 1.24-3.37], as well as macrosomia risk (aOR 2.02, 95% CI 1.11-3.66; aOR 5.04, 95% CI 2.03-12.52) and large-for-gestational age infants (aOR 1.48, 95% CI 1.02-2.16; aOR 4.34, 95% CI 2.31-8.15). Pregnancy outcomes were similar for normal glucose tolerance and GDM with normal FBG in OGTT. Mild gestational hyperglycemia raised the likelihood of adverse maternal outcomes and excessive infant birth weights. Even after achieving target glucose levels, GDM patients with elevated fasting glucose readings in OGTT remained at significant risk for these events. Instead, fasting normoglycemic GDM was treated effectively at Macau Health Centers.
Competing Interests: The authors have no funding and conflicts of interest to disclose.
(Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)
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المشرفين على المادة: IY9XDZ35W2 (Glucose)
تواريخ الأحداث: Date Created: 20230915 Date Completed: 20230918 Latest Revision: 20230921
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10508387
DOI: 10.1097/MD.0000000000035175
PMID: 37713817
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-5964
DOI:10.1097/MD.0000000000035175