دورية أكاديمية
Impaired Reverse Cholesterol Transport is Associated with Changes in Fatty Acid Profile in Children and Adolescents with Abdominal Obesity.
| العنوان: | Impaired Reverse Cholesterol Transport is Associated with Changes in Fatty Acid Profile in Children and Adolescents with Abdominal Obesity. |
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| المؤلفون: | Martin M; Laboratorio de Lípidos y Aterosclerosis, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina. Electronic address: maxie_martin@hotmail.com., Condori AI; Departamento de Sanidad, Nutrición, Bromatología y Toxicología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina., Davico B; Laboratorio de Lípidos y Aterosclerosis, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina., Gómez Rosso L; Laboratorio de Lípidos y Aterosclerosis, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina., Gaete L; Hospital de Niños 'Ricardo Gutiérrez', Buenos Aires, Argentina., Tetzlaff W; Laboratorio de Lípidos y Aterosclerosis, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina., Chiappe EL; Laboratorio de Lípidos y Aterosclerosis, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina., Sáez MS; Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Lorenzon González MV; Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Godoy MF; Departamento de Sanidad, Nutrición, Bromatología y Toxicología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina., Osta V; Hospital de Niños 'Ricardo Gutiérrez', Buenos Aires, Argentina., Trifone L; Hospital de Niños 'Ricardo Gutiérrez', Buenos Aires, Argentina., Ballerini MG; Laboratorio de Lípidos y Aterosclerosis, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina., Cherñavsky A; Instituto de Inmunología, Genética y Metabolismo, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina., Boero L; Laboratorio de Lípidos y Aterosclerosis, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina., Tonietti M; Hospital de Niños 'Ricardo Gutiérrez', Buenos Aires, Argentina., Feliu S; Departamento de Sanidad, Nutrición, Bromatología y Toxicología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina., Brites F; Laboratorio de Lípidos y Aterosclerosis, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina. |
| المصدر: | The Journal of nutrition [J Nutr] 2024 Jan; Vol. 154 (1), pp. 12-25. Date of Electronic Publication: 2023 Sep 15. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0404243 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1541-6100 (Electronic) Linking ISSN: 00223166 NLM ISO Abbreviation: J Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [New York, NY] : Elsevier Original Publication: 1928-1933 : Springfield, Ill. : C. C. Thomas |
| مواضيع طبية MeSH: | Fatty Acids* , Cardiovascular Diseases*, Humans ; Adolescent ; Child ; Obesity, Abdominal ; Obesity ; Cholesterol/metabolism ; Linoleic Acids ; Myristic Acids |
| مستخلص: | Background: Abdominal obesity is an important cardiovascular disease risk factor. Plasma fatty acids display a complex network of both pro and antiatherogenic effects. High density lipoproteins (HDL) carry out the antiatherogenic pathway called reverse cholesterol transport (RCT), which involves cellular cholesterol efflux (CCE), and lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) activities. Objectives: Our aim was to characterize RCT and its relation to fatty acids present in plasma in pediatric abdominal obesity. Methods: Seventeen children and adolescents with abdominal obesity and 17 healthy controls were studied. Anthropometric parameters were registered. Glucose, insulin, lipid levels, CCE employing THP-1 cells, LCAT and CETP activities, plus fatty acids in apo B-depleted plasma were measured. Results: The obese group showed a more atherogenic lipid profile, plus lower CCE (Mean±Standard Deviation) (6 ± 2 vs. 7 ± 2%; P < 0.05) and LCAT activity (11 ± 3 vs. 15 ±5 umol/dL.h; P < 0.05). With respect to fatty acids, the obese group showed higher myristic (1.1 ± 0.3 vs. 0.7 ± 0.3; P < 0.01) and palmitic acids (21.5 ± 2.8 vs. 19.6 ± 1.9; P < 0.05) in addition to lower linoleic acid (26.4 ± 3.3 vs. 29.9 ± 2.6; P < 0.01). Arachidonic acid correlated with CCE (r = 0.37; P < 0.05), myristic acid with LCAT (r = -0.37; P < 0.05), palmitioleic acid with CCE (r = -0.35; P < 0.05), linoleic acid with CCE (r = 0.37; P < 0.05), lauric acid with LCAT (r = 0.49; P < 0.05), myristic acid with LCAT (r = -0.37; P < 0.05) ecoisatrienoic acid with CCE (r = 0.40; P < 0.05) and lignoseric acid with LCAT (r = -0.5; P < 0.01). Conclusions: Children and adolescents with abdominal obesity presented impaired RCT, which was associated with modifications in proinflammatory fatty acids, such as palmitoleic and myristic, thus contributing to increased cardiovascular disease risk. (Copyright © 2023 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: J Nutr. 2024 Jan;154(1):3-4. (PMID: 37806353) |
| فهرسة مساهمة: | Keywords: CETP; HDL; LCAT; abdominal obesity; cholesterol efflux; fatty acid profile |
| المشرفين على المادة: | 0 (Fatty Acids) 97C5T2UQ7J (Cholesterol) 0 (Linoleic Acids) 0 (Myristic Acids) |
| تواريخ الأحداث: | Date Created: 20230916 Date Completed: 20240115 Latest Revision: 20240223 |
| رمز التحديث: | 20240223 |
| DOI: | 10.1016/j.tjnut.2023.08.037 |
| PMID: | 37716606 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1541-6100 |
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| DOI: | 10.1016/j.tjnut.2023.08.037 |