دورية أكاديمية
أعرض في EDS

Effects of alternate-day fasting and time-restricted feeding in obese middle-aged female rats.

التفاصيل البيبلوغرافية
العنوان: Effects of alternate-day fasting and time-restricted feeding in obese middle-aged female rats.
المؤلفون: Bilibio BLE; Research Group in Physiology, Regional University of Northwestern Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil; Postgraduate Program in Integral Attention to Health, Regional University of Northwestern Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil., Dos Reis WR; Research Group in Physiology, Regional University of Northwestern Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil., Compagnon L; Research Group in Physiology, Regional University of Northwestern Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil; Postgraduate Program in Integral Attention to Health, Regional University of Northwestern Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil., de Batista DG; Research Group in Physiology, Regional University of Northwestern Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil; Postgraduate Program in Integral Attention to Health, Regional University of Northwestern Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil; Postgraduate Program in Mathematical and Computational Modelling, Regional University of North-western Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil., Sulzbacher LM; Research Group in Physiology, Regional University of Northwestern Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil; Postgraduate Program in Integral Attention to Health, Regional University of Northwestern Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil., Pinheiro JF; Research Group in Physiology, Regional University of Northwestern Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil., Ludwig MS; Research Group in Physiology, Regional University of Northwestern Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil; Postgraduate Program in Integral Attention to Health, Regional University of Northwestern Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil., Frizzo MN; Research Group in Physiology, Regional University of Northwestern Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil; Postgraduate Program in Integral Attention to Health, Regional University of Northwestern Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil., Cruzat V; Faculty of Health, Southern Cross University, Gold Coast, Queensland, Australia. Electronic address: vini.cruzat@scu.edu.au., Heck TG; Research Group in Physiology, Regional University of Northwestern Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil; Postgraduate Program in Integral Attention to Health, Regional University of Northwestern Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil; Postgraduate Program in Mathematical and Computational Modelling, Regional University of North-western Rio Grande do Sul State, Ijuí, Rio Grande do Sul State, Brazil.
المصدر: Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2023 Dec; Vol. 116, pp. 112198. Date of Electronic Publication: 2023 Aug 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8802712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1244 (Electronic) Linking ISSN: 08999007 NLM ISO Abbreviation: Nutrition Subsets: MEDLINE
أسماء مطبوعة: Publication: Tarrytown, NY : Elsevier Science
Original Publication: [Burbank, Calif. : Nutrition, c1987-
مواضيع طبية MeSH: Insulin Resistance*/physiology, Rats ; Female ; Animals ; Rats, Wistar ; Obesity ; Fasting ; Body Weight ; Lipids
مستخلص: Objectives: Obesity is a multifactorial condition associated with metabolic alterations that can be aggravated during female aging. Calorie restriction via intermittent fasting (IF) diets may reduce body weight and therefore have the potential to decrease obesity and associated comorbidities, such as insulin resistance. This study investigated the effects of two IF protocols, alternate-day fasting (ADF) and time-restricted feeding (TRF) in middle-aged obese female rats.
Methods: Wistar rats (age 15 mo) were fed with standard chow or high-fat diet for 8 wk and then separated into the following groups (n = 5-8 each) for another 8 wk: control (received standard chow), obese (received high-fat diet), obese + ADF (24-h fasting protocol), and obese + TRF (14 h daily).
Results: At the end of the study, both IF protocols were able to reduce body weight and body mass index compared with the obese group. However, no changes were observed in adiposity and glucose homeostasis. We also found an increase in total leukocytes, lymphocytes, and monocytes in the TRF group and a higher number of platelets in the ADF group. Blood lipid profiles, including triglycerides and high-density lipoprotein, as well as liver stress responses, such as heat shock protein 70 and malondialdehyde, were not changed by IF.
Conclusions: Although ADF and TRF protocols resulted in a reduction of body weight and body mass index, these dietary interventions did not promote health benefits, such as reducing blood lipid profile, adiposity, and insulin resistance. In addition, ADF and TRF increased inflammatory biomarkers, which may increase the risk of obesity-associated comorbidities.
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to declare regarding the execution of this study nor manuscript for publication. All authors have agreed with the contents of the manuscript and there is no financial interest to report. We also confirm that the submission is original work and is not under review at any other publication.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: adiposity; high-fat diet; inflammation; intermittent fasting; obesity; oxidative stress; weight loss
المشرفين على المادة: 0 (Lipids)
تواريخ الأحداث: Date Created: 20230917 Date Completed: 20231114 Latest Revision: 20231114
رمز التحديث: 20240628
DOI: 10.1016/j.nut.2023.112198
PMID: 37717500
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-1244
DOI:10.1016/j.nut.2023.112198