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Adolescent Alcohol Exposure Produces Sex-Specific Long-term Hyperalgesia via Changes in Central Amygdala Circuit Function.

التفاصيل البيبلوغرافية
العنوان: Adolescent Alcohol Exposure Produces Sex-Specific Long-term Hyperalgesia via Changes in Central Amygdala Circuit Function.
المؤلفون: Secci ME; Department of Physiology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana., Kelley LK; Department of Physiology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana., Avegno EM; Department of Physiology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana; Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana., Holmgren EB; Department of Anatomy and Cell Biology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana., Chen L; Department of Anatomy and Cell Biology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana., Rein SL; Department of Anatomy and Cell Biology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana., Engi SA; Department of Anatomy and Cell Biology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana., Quinlan V; Department of Physiology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana., Wilson L; Department of Anatomy and Cell Biology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana., Gilpin NW; Department of Physiology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana; Neuroscience Center of Excellence, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana; Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana; Veterans Affairs Southeast Louisiana Healthcare System, New Orleans, Louisiana., Wills TA; Department of Anatomy and Cell Biology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana; Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana. Electronic address: twills@lsuhsc.edu.
المصدر: Biological psychiatry [Biol Psychiatry] 2024 Feb 01; Vol. 95 (3), pp. 207-219. Date of Electronic Publication: 2023 Sep 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Elsevier
Original Publication: New York, Plenum Pub. Corp.
مواضيع طبية MeSH: Central Amygdaloid Nucleus* , Underage Drinking*, Humans ; Adolescent ; Male ; Rats ; Female ; Animals ; Hyperalgesia ; Ethanol/pharmacology ; Pain
مستخلص: Background: Exposure to alcohol during adolescence produces many effects that last well into adulthood. Acute alcohol use is analgesic, and people living with pain report drinking alcohol to reduce pain, but chronic alcohol use produces increases in pain sensitivity.
Methods: We tested the acute and lasting effects of chronic adolescent intermittent ethanol (AIE) exposure on pain-related behavioral and brain changes in male and female rats. We also tested the long-term effects of AIE on synaptic transmission in midbrain (ventrolateral periaqueductal gray [vlPAG])-projecting central amygdala (CeA) neurons using whole-cell electrophysiology. Finally, we used circuit-based approaches (DREADDs [designer receptors exclusively activated by designer drugs]) to test the role of vlPAG-projecting CeA neurons in mediating AIE effects on pain-related outcomes.
Results: AIE produced long-lasting hyperalgesia in male, but not female, rats. Similarly, AIE led to a reduction in synaptic strength of medial CeA cells that project to the vlPAG in male, but not female, rats. Challenge with an acute painful stimulus (i.e., formalin) in adulthood produced expected increases in pain reactivity, and this effect was exaggerated in male rats with a history of AIE. Finally, CeA-vlPAG circuit activation rescued AIE-induced hypersensitivity in male rats.
Conclusions: Our findings are the first, to our knowledge, to show long-lasting sex-dependent effects of adolescent alcohol exposure on pain-related behaviors and brain circuits in adult animals. This work has implications for understanding the long-term effects of underage alcohol drinking on pain-related behaviors in humans.
(Copyright © 2023 Society of Biological Psychiatry. All rights reserved.)
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معلومات مُعتمدة: I01 BX003451 United States BX BLRD VA; U01 AA028709 United States AA NIAAA NIH HHS
فهرسة مساهمة: Keywords: Adolescents; Alcohol; Central amygdala; Pain; Rats; Ventral lateral periaqueductal gray
المشرفين على المادة: 3K9958V90M (Ethanol)
تواريخ الأحداث: Date Created: 20230917 Date Completed: 20231226 Latest Revision: 20240216
رمز التحديث: 20240216
مُعرف محوري في PubMed: PMC10866691
DOI: 10.1016/j.biopsych.2023.09.006
PMID: 37717844
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2402
DOI:10.1016/j.biopsych.2023.09.006