دورية أكاديمية
أعرض في EDS

Resolvin D2-G-Protein Coupled Receptor 18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging.

التفاصيل البيبلوغرافية
العنوان: Resolvin D2-G-Protein Coupled Receptor 18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging.
المؤلفون: Fitzgerald H; The Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York., Bonin JL; The Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York., Khan S; The Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York., Eid M; The Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York., Sadhu S; The Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York., Rahtes A; The Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York., Lipscomb M; The Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York., Biswas N; The Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York., Decker C; The Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York., Nabage M; The Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York., Ramos RB; The Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York., Duarte GA; The Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York., Marinello M; The Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York., Chen A; Department of Pathology, Albany Medical College, Albany, New York., Aydin HB; Department of Pathology, Albany Medical College, Albany, New York., Mena HA; Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Gilliard K; The Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York., Spite M; Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., DiPersio CM; The Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York; Department of Surgery, Albany Medical College, Albany, New York., Adam AP; The Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York., MacNamara KC; The Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York. Electronic address: macnamk@amc.edu., Fredman G; The Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York. Electronic address: fredmag@amc.edu.
المصدر: The American journal of pathology [Am J Pathol] 2023 Dec; Vol. 193 (12), pp. 1953-1968. Date of Electronic Publication: 2023 Sep 16.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0370502 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-2191 (Electronic) Linking ISSN: 00029440 NLM ISO Abbreviation: Am J Pathol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011-: New York : Elsevier
Original Publication: Philadelphia [etc.] American Assn. of Pathologists [etc.]
مواضيع طبية MeSH: Bone Marrow*/metabolism , Fatty Liver*, Middle Aged ; Humans ; Mice ; Animals ; Aged ; Receptors, G-Protein-Coupled/metabolism ; Aging ; Liver Cirrhosis ; Fibrosis ; Collagen/genetics ; Mice, Inbred C57BL
مستخلص: Aging is associated with nonresolving inflammation and tissue dysfunction. Resolvin D2 (RvD2) is a proresolving ligand that acts through the G-protein-coupled receptor called GPR18. Unbiased RNA sequencing revealed increased Gpr18 expression in macrophages from old mice, and in livers from elderly humans, which was associated with increased steatosis and fibrosis in middle-aged (MA) and old mice. MA mice that lacked GPR18 on myeloid cells had exacerbated steatosis and hepatic fibrosis, which was associated with a decline in Mac2 + macrophages. Treatment of MA mice with RvD2 reduced steatosis and decreased hepatic fibrosis, correlating with increased Mac2 + macrophages, increased monocyte-derived macrophages, and elevated numbers of monocytes in the liver, blood, and bone marrow. RvD2 acted directly on the bone marrow to increase monocyte-macrophage progenitors. A transplantation assay further demonstrated that bone marrow from old mice facilitated hepatic collagen accumulation in young mice. Transient RvD2 treatment to mice transplanted with bone marrow from old mice prevented hepatic collagen accumulation. Together, this study demonstrates that RvD2-GPR18 signaling controls steatosis and fibrosis and provides a mechanistic-based therapy for promoting liver repair in aging.
(Copyright © 2023 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 HL106173 United States HL NHLBI NIH HHS; R01 HL153019 United States HL NHLBI NIH HHS; R01 AR063778 United States AR NIAMS NIH HHS; R35 GM131842 United States GM NIGMS NIH HHS; R01 HL170249 United States HL NHLBI NIH HHS
المشرفين على المادة: 0 (resolvin D2)
0 (Receptors, G-Protein-Coupled)
9007-34-5 (Collagen)
تواريخ الأحداث: Date Created: 20230917 Date Completed: 20231120 Latest Revision: 20240130
رمز التحديث: 20240130
مُعرف محوري في PubMed: PMC10699127
DOI: 10.1016/j.ajpath.2023.08.011
PMID: 37717941
قاعدة البيانات: MEDLINE
الوصف
تدمد:1525-2191
DOI:10.1016/j.ajpath.2023.08.011