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Dosimetric comparison between RapidArc and HyperArc in hippocampal-sparing whole-brain radiotherapy with a simultaneous integrated boost.

التفاصيل البيبلوغرافية
العنوان: Dosimetric comparison between RapidArc and HyperArc in hippocampal-sparing whole-brain radiotherapy with a simultaneous integrated boost.
المؤلفون: Kim J; Departments of Radiation Oncology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea., Kim TG; Departments of Radiation Oncology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea. Electronic address: tg1.kim@samsung.com., Park B; Departments of Radiation Oncology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea., Kim H; Departments of Radiation Oncology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea., Song YG; Departments of Radiology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea., Lee HW; Departments of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea., Kim YZ; Departments of Neurosurgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea., Ji JH; Departments of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea., Kim SH; Departments of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea., Kim SM; Departments of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea., Lee JH; Departments of Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea., Kim H; Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
المصدر: Medical dosimetry : official journal of the American Association of Medical Dosimetrists [Med Dosim] 2024 Summer; Vol. 49 (2), pp. 69-76. Date of Electronic Publication: 2023 Sep 16.
نوع المنشور: Journal Article; Comparative Study
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8908862 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4022 (Electronic) Linking ISSN: 18734022 NLM ISO Abbreviation: Med Dosim Subsets: MEDLINE
أسماء مطبوعة: Publication: <2000->: New York, NY : Elsevier Science
Original Publication: [Southwest Harbor, Me. : Beech Hill Pub.,
مواضيع طبية MeSH: Brain Neoplasms*/radiotherapy , Hippocampus* , Radiotherapy Planning, Computer-Assisted*/methods , Radiotherapy, Intensity-Modulated*/methods , Radiotherapy Dosage* , Cranial Irradiation*/methods, Humans ; Organ Sparing Treatments/methods ; Retrospective Studies ; Organs at Risk
مستخلص: The HyperArc technique is known for generating high-quality radiosurgical treatment plans for intracranial lesions or hippocampal-sparing whole-brain radiotherapy (WBRT). However, there is no reported feasibility of using the HyperArc technique in hippocampal-sparing WBRT with a simultaneous integrated boost (SIB). This study aimed to compare dosimetric parameters of 2 commercially-available volumetric-modulated arc radiotherapy techniques, HyperArc and RapidArc, when using hippocampal-sparing WBRT with a SIB to treat brain metastases. Treatment plans using HyperArc and RapidArc techniques were generated retrospectively for 19 previously treated patients (1 to 3 brain metastases). The planning target volumes for the whole brain (excluding the hippocampal avoidance region; PTV WB ) and metastases (PTV met ) were prescribed 25 and 45 Gy, respectively, in 10 fractions. Each plan included homogeneous and inhomogeneous delivery to the PTV met . Dosimetric parameters for the target (conformity index [CI], homogeneity index [HI], target coverage [D 95% ]), and nontarget organs at risk were compared for the HyperArc and RapidArc plans. For homogeneous delivery, dosimetric parameters, including mean CI, HI, and target coverage in PTV WB and PTV met , were superior for HyperArc than RapidArc plans (all p < 0.01). The PTV WB and PTV met target coverage for HyperArc plans was significantly greater than for RapidArc plans (96.17% vs 93.38%, p < 0.01; 94.02% vs 92.21%, p < 0.01, respectively). HyperArc plans had significantly lower mean hippocampal D max and D min values than RapidArc plans (D max : 15.53 Gy vs, 16.71 Gy, p < 0.01; D min : 8.33 Gy vs 8.93 Gy, p < 0.01, respectively). Similarly, inhomogeneous delivery of hyperArc produced a superior target and lower hippocampal dosimetric parameters than RapidArc, except for the HI of PTV met (all p < 0.01). HyperArc generated superior conformity and target coverage with lower hippocampal doses than RapidArc. HyperArc could be an attractive technique for hippocampal-sparing WBRT with an SIB.
(Copyright © 2023 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Hippocampus; HyperArc; Simultaneous integrated boost; Whole-brain radiation therapy
تواريخ الأحداث: Date Created: 20230917 Date Completed: 20240506 Latest Revision: 20240506
رمز التحديث: 20240507
DOI: 10.1016/j.meddos.2023.08.007
PMID: 37718172
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-4022
DOI:10.1016/j.meddos.2023.08.007