دورية أكاديمية
أعرض في EDS

Investigating the Impact of Hydrophobic Polymer Segments on the Self-Assembly Behavior of Supramolecular Cyclic Peptide Systems via Asymmetric-Flow Field Flow Fractionation.

التفاصيل البيبلوغرافية
العنوان: Investigating the Impact of Hydrophobic Polymer Segments on the Self-Assembly Behavior of Supramolecular Cyclic Peptide Systems via Asymmetric-Flow Field Flow Fractionation.
المؤلفون: Kariuki M; Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K., Rho JY; Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K., Hall SCL; ISIS Neutron and Muon Source, Rutherford Appleton Laboratory, Didcot OX11 0QX, U.K., Perrier S; Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.; Warwick Medical School, University of Warwick, Coventry CV4 7AL, U.K.; Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
المصدر: Macromolecules [Macromolecules] 2023 Aug 26; Vol. 56 (17), pp. 6618-6632. Date of Electronic Publication: 2023 Aug 26 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0365316 Publication Model: eCollection Cited Medium: Print ISSN: 0024-9297 (Print) Linking ISSN: 00249297 NLM ISO Abbreviation: Macromolecules Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Washington, American Chemical Society.
مستخلص: The present study examines the behavior of cyclic peptide polymer conjugates that have been designed to combine their self-assembling ability via H-bonding with the properties of amphiphilic diblock copolymers. Using a combination of asymmetric flow-field flow fractionation (AF 4 ) and small-angle neutron scattering (SANS), we have uncovered unique insight based on the population of structures established at a 24 h equilibrium profile. Our results determine that by introducing a small quantity of hydrophobicity into the conjugated polymer corona, the resulting nanotube structures exhibit low unimer dissociation which signifies enhanced stability. Furthermore, as the hydrophobicity of the polymer corona is increased, the elongation of the nanotubes is observed due to an increase in the association of unimers. This encompasses not only the H-bonding of unimers into nanotubes but also the self-assembly of single nanotubes into segmented-nanotube structures with high aspect ratios. However, this influence relies on a subtle balance between the hydrophobicity and hydrophilicity of the polymer corona. This balance is proposed to determine the solvent entropic penalty of hydrating the system, whereby the cost scales with the hydrophobic quantity. Consequently, it has been suggested that at a critical hydrophobic quantity, the solvation penalty becomes high enough such that the self-assembly of the system deviates from ordered hydrogen bonding. The association behavior is instead dominated by the hydrophobic effect which results in the undesirable formation of disordered aggregates.
Competing Interests: The authors declare no competing financial interest.
(© 2023 The Authors. Published by American Chemical Society.)
References: Chromatographia. 2022 Apr;85(4):. (PMID: 36620523)
Nat Commun. 2019 Oct 17;10(1):4708. (PMID: 31624265)
Eur J Biochem. 1984 Jan 16;138(2):345-8. (PMID: 6697991)
Chem Rev. 2016 Feb 24;116(4):2414-77. (PMID: 26727633)
Angew Chem Int Ed Engl. 2019 Nov 18;58(47):16730-16740. (PMID: 31271244)
J Am Chem Soc. 2011 Nov 23;133(46):18903-10. (PMID: 21981450)
J Phys Chem B. 2016 Apr 7;120(13):3425-33. (PMID: 26938206)
RSC Chem Biol. 2020 Aug 28;1(4):281-287. (PMID: 34458766)
ACS Macro Lett. 2022 Apr 19;11(4):498-503. (PMID: 35575334)
Chem Commun (Camb). 2021 Feb 15;57(12):1413-1429. (PMID: 33439172)
Nature. 1993 Nov 25;366(6453):324-7. (PMID: 8247126)
Org Lett. 2014 Aug 1;16(15):4016-9. (PMID: 25035966)
J Am Chem Soc. 2007 Dec 19;129(50):15601-5. (PMID: 18034476)
Chem Commun (Camb). 2020 Oct 27;56(85):12901-12904. (PMID: 32996934)
Chem Rev. 2021 Nov 24;121(22):13936-13995. (PMID: 33938738)
Adv Drug Deliv Rev. 2011 Mar 18;63(3):131-5. (PMID: 20304019)
Chem Soc Rev. 2012 Sep 21;41(18):5922-32. (PMID: 22674180)
Chem Soc Rev. 2012 Sep 21;41(18):6023-41. (PMID: 22875035)
Molecules. 2020 Jul 31;25(15):. (PMID: 32751865)
Biopolymers. 2010;94(1):1-18. (PMID: 20091874)
Chem Rev. 2015 Aug 12;115(15):7196-239. (PMID: 25768045)
Angew Chem Int Ed Engl. 2018 Dec 17;57(51):16678-16682. (PMID: 30383920)
Biomaterials. 2018 Sep;178:570-582. (PMID: 29680158)
Angew Chem Int Ed Engl. 2020 Jun 2;59(23):8860-8863. (PMID: 32045099)
J Chromatogr A. 2016 Sep 23;1465:155-64. (PMID: 27575921)
J Am Chem Soc. 2011 Oct 5;133(39):15296-9. (PMID: 21894889)
ACS Macro Lett. 2020 Nov 17;9(11):1700-1707. (PMID: 33299653)
J Phys Chem B. 2020 Nov 19;124(46):10326-10336. (PMID: 33147018)
Soft Matter. 2014 Feb 14;10(6):851-61. (PMID: 24652037)
J Am Chem Soc. 2014 Jun 18;136(24):8540-3. (PMID: 24911245)
Chem Soc Rev. 2017 Jul 17;46(14):4119-4134. (PMID: 28598465)
J Phys Chem B. 2022 Jan 27;126(3):634-642. (PMID: 35025490)
Annu Rev Biophys. 2013;42:121-42. (PMID: 23654303)
Anal Chem. 2003 Aug 15;75(16):4279-91. (PMID: 14632147)
Science. 2012 Feb 17;335(6070):813-7. (PMID: 22344437)
Soft Matter. 2018 Aug 1;14(30):6320-6326. (PMID: 30019044)
Chem Rev. 2009 Nov;109(11):5687-754. (PMID: 19769364)
Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):322-327. (PMID: 28028244)
Chemistry. 2011 Aug 8;17(33):9016-26. (PMID: 21726009)
Small. 2008 Jul;4(7):1008-16. (PMID: 18576283)
Soft Matter. 2015 May 21;11(19):3822-32. (PMID: 25858105)
Adv Mater. 2019 Aug;31(32):e1901556. (PMID: 31148285)
Molecules. 2022 Oct 18;27(20):. (PMID: 36296602)
Biophys Chem. 1994 Aug;51(2-3):271-7; discussion 277-8. (PMID: 7919038)
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5133-8. (PMID: 11929981)
Angew Chem Int Ed Engl. 2021 Feb 19;60(8):4368-4376. (PMID: 33152151)
Environ Sci Technol. 2012 Feb 7;46(3):1496-503. (PMID: 22191628)
J Am Chem Soc. 2004 Dec 29;126(51):16762-71. (PMID: 15612714)
Nature. 2000 Sep 14;407(6801):167-70. (PMID: 11001050)
Anal Bioanal Chem. 2009 Aug;394(7):1887-93. (PMID: 19554314)
تواريخ الأحداث: Date Created: 20230918 Latest Revision: 20230921
رمز التحديث: 20230921
مُعرف محوري في PubMed: PMC10501196
DOI: 10.1021/acs.macromol.3c00442
PMID: 37720562
قاعدة البيانات: MEDLINE
الوصف
تدمد:0024-9297
DOI:10.1021/acs.macromol.3c00442