دورية أكاديمية
Goal-seeking compresses neural codes for space in the human hippocampus and orbitofrontal cortex.
| العنوان: | Goal-seeking compresses neural codes for space in the human hippocampus and orbitofrontal cortex. |
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| المؤلفون: | Muhle-Karbe PS; Department of Experimental Psychology, University of Oxford, Oxford OX2 6GG, UK; School of Psychology, University of Birmingham, Birmingham B15 2SA, UK; Centre for Human Brain Health, University of Birmingham, Birmingham B15 2SA, UK. Electronic address: p.muhle-karbe@bham.ac.uk., Sheahan H; Department of Experimental Psychology, University of Oxford, Oxford OX2 6GG, UK; Google DeepMind, London EC4A 3TW, UK., Pezzulo G; Institute of Cognitive Sciences and Technologies, National Research Council, 00185 Rome, Italy., Spiers HJ; Department of Experimental Psychology, University College London, London WC1E 6BT, UK., Chien S; Max Planck Research Group NeuroCode, Max Planck Institute for Human Development, 14195 Berlin, Germany., Schuck NW; Max Planck Research Group NeuroCode, Max Planck Institute for Human Development, 14195 Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Aging Research, 14195 Berlin, Germany; Institute of Psychology, Universität Hamburg, 20146 Hamburg, Germany., Summerfield C; Department of Experimental Psychology, University of Oxford, Oxford OX2 6GG, UK; Centre for Human Brain Health, University of Birmingham, Birmingham B15 2SA, UK. Electronic address: christopher.summerfield@psy.ox.ac.uk. |
| المصدر: | Neuron [Neuron] 2023 Dec 06; Vol. 111 (23), pp. 3885-3899.e6. Date of Electronic Publication: 2023 Sep 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, Mass. : Cell Press, c1988- |
| مواضيع طبية MeSH: | Neocortex* , Spatial Navigation*, Humans ; Goals ; Prospective Studies ; Hippocampus ; Prefrontal Cortex ; Space Perception |
| مستخلص: | Humans can navigate flexibly to meet their goals. Here, we asked how the neural representation of allocentric space is distorted by goal-directed behavior. Participants navigated an agent to two successive goal locations in a grid world environment comprising four interlinked rooms, with a contextual cue indicating the conditional dependence of one goal location on another. Examining the neural geometry by which room and context were encoded in fMRI signals, we found that map-like representations of the environment emerged in both hippocampus and neocortex. Cognitive maps in hippocampus and orbitofrontal cortices were compressed so that locations cued as goals were coded together in neural state space, and these distortions predicted successful learning. This effect was captured by a computational model in which current and prospective locations are jointly encoded in a place code, providing a theory of how goals warp the neural representation of space in macroscopic neural signals. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: cognitive control; cognitive maps; context-based decisions; hippocampus; orbitofrontal cortex; planning; representational geometry; spatial navigation |
| تواريخ الأحداث: | Date Created: 20230919 Date Completed: 20231216 Latest Revision: 20231216 |
| رمز التحديث: | 20231217 |
| DOI: | 10.1016/j.neuron.2023.08.021 |
| PMID: | 37725981 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1097-4199 |
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| DOI: | 10.1016/j.neuron.2023.08.021 |