دورية أكاديمية
A fruit extract of Styphnolobium japonicum (L.) counteracts oxidative stress and mediates neuroprotection in Caenorhabditis elegans.
العنوان: | A fruit extract of Styphnolobium japonicum (L.) counteracts oxidative stress and mediates neuroprotection in Caenorhabditis elegans. |
---|---|
المؤلفون: | Thabit S; Department of Pharmaceutical Biology, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo, 11835, Egypt. sara.thabit@guc.edu.eg., Handoussa H; Department of Pharmaceutical Biology, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo, 11835, Egypt., ElSayed NS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Breitinger HG; Department of Biochemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo, Egypt., Breitinger U; Department of Biochemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo, Egypt., Wink M; Department of Biology, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany. |
المصدر: | BMC complementary medicine and therapies [BMC Complement Med Ther] 2023 Sep 19; Vol. 23 (1), pp. 330. Date of Electronic Publication: 2023 Sep 19. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101761232 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-7671 (Electronic) Linking ISSN: 26627671 NLM ISO Abbreviation: BMC Complement Med Ther Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : BioMed Central, [2020]- |
مواضيع طبية MeSH: | Sophora japonica* , Parkinson Disease*, Animals ; Neuroprotection ; Caenorhabditis elegans ; Fruit ; alpha-Synuclein ; Amyloid beta-Peptides ; Oxidative Stress ; Plant Extracts/pharmacology |
مستخلص: | Background: Despite its widespread uses in Chinese and European medicine, Styphnolobium japonicum (Chinese scholar tree, formerly Sophora japonicum) has not been extensively investigated for its potential to protect against neurodegenerative processes and to promote resistance to oxidative stress. In this study, we evaluated the neuroprotective activities of a hydroalcoholic extract from Chinese scholar tree fruits that could be possibly linked to its antioxidant properties using Caenorhabditis elegans as a well-established in vivo model. Methods: Survival rate in mutant daf-16 and skn-1 worms, stressed by the pro-oxidant juglone and treated with the extract, was tested. Localization of the transcription factors SKN-1 and DAF-16, and expression of gst-4 were measured. For evaluation of neuroprotective effects, formation of polyglutamine (polyQ40) clusters, α-synuclein aggregates, loss of amphid sensilla (ASH) neuronal function, and amyloid β (Aβ) accumulation (as markers for Huntington's, Parkinson's, and Alzheimer's) was examined. Results: The extract, which contains substantial amounts of phenolic phytochemicals, showed an increase in the survival rate of worms challenged with juglone in daf-16 mutants but not in skn-1 mutants. The transcription factor SKN-1 was activated by the extract, while DAF-16 was not affected. Upon application of the extract, a significant decline in GST-4 levels, polyQ40 cluster formation, number of lost ASH sensory neurons, α-synuclein aggregation, and paralysis resulting from Aβ accumulation was observed. Conclusions: Styphnolobium japonicum fruit extract activated the SKN-1/Nrf2 pathway, resulting in oxidative stress resistance. It revealed promising pharmacological activities towards treatment of Huntington's, Parkinson's, and Alzheimer's diseases. Polyphenolics from Styphnolobium japonicum may be a promising route towards treatment of CNS disorders, but need to be tested in other in vivo systems. (© 2023. BioMed Central Ltd., part of Springer Nature.) |
References: | Eur J Clin Pharmacol. 1996;50(6):443-7. (PMID: 8858269) Molecules. 2013 Aug 19;18(8):9949-65. (PMID: 23966081) Curr Drug Metab. 2008 Dec;9(10):996-1009. (PMID: 19075616) Phytochemistry. 2009 Apr;70(6):785-94. (PMID: 19447452) Br J Haematol. 2008 Feb;140(4):365-77. (PMID: 18162121) Phytomedicine. 2006 Nov;13(9-10):718-23. (PMID: 17085294) Biomed Pharmacother. 2018 Jun;102:812-822. (PMID: 29605769) Molecules. 2019 Jul 19;24(14):. (PMID: 31331055) Pharmacol Res. 2007 Feb;55(2):139-47. (PMID: 17207635) Eur J Pharmacol. 2018 Jan 15;819:169-180. (PMID: 29208474) Exp Gerontol. 2011 Jun;46(6):441-52. (PMID: 21296648) Neurobiol Aging. 2003 May-Jun;24(3):415-20. (PMID: 12600717) Med Res Rev. 2020 Nov;40(6):2650-2681. (PMID: 32767426) Nat Rev Neurol. 2020 Oct;16(10):529-546. (PMID: 32796930) Free Radic Biol Med. 2014 Apr;69:258-64. (PMID: 24491879) Annu Rev Food Sci Technol. 2022 Mar 25;13:337-359. (PMID: 35333591) Ann Neurol. 2003;53 Suppl 3:S26-36; discussion S36-8. (PMID: 12666096) Food Funct. 2020 Jan 29;11(1):347-357. (PMID: 31799533) Genes Dev. 2005 Oct 1;19(19):2278-83. (PMID: 16166371) Toxicology. 2007 May 5;234(1-2):113-23. (PMID: 17376580) Free Radic Biol Med. 2015 Nov;88(Pt B):290-301. (PMID: 26232625) Biosci Biotechnol Biochem. 2006 Oct;70(10):2556-9. (PMID: 17031059) Free Radic Biol Med. 2013 Sep;62:186-201. (PMID: 23743292) J Ethnopharmacol. 2016 Jul 1;187:160-82. (PMID: 27085938) Fitoterapia. 2016 Sep;113:123-7. (PMID: 27370100) Neuromuscul Disord. 2004 Jun;14(6):365-70. (PMID: 15145337) Br J Dermatol. 2016 Oct;175 Suppl 2:26-29. (PMID: 27667312) Mol Cell Biochem. 2006 Dec;293(1-2):211-9. (PMID: 16786186) J Asian Nat Prod Res. 2002 Jun;4(2):123-8. (PMID: 12067157) Biomed Res Int. 2014;2014:701758. (PMID: 25309920) J Neurochem. 2006 Apr;97(1):105-15. (PMID: 16524383) Molecules. 2014 Jun 10;19(6):7757-69. (PMID: 24918543) Adv Exp Med Biol. 2010;694:138-59. (PMID: 20886762) PeerJ. 2018 Jul 13;6:e5159. (PMID: 30023139) J Agric Food Chem. 2011 Dec 14;59(23):12361-7. (PMID: 22023309) Adv Exp Med Biol. 2010;685:34-44. (PMID: 20687493) Mol Cell Neurosci. 2008 Nov;39(3):302-13. (PMID: 18706502) Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):97-103. (PMID: 16433898) Am J Chin Med. 2005;33(3):425-38. (PMID: 16047560) Clin Exp Dermatol. 2006 Jul;31(4):548-52. (PMID: 16716161) J Clin Invest. 2015 Apr;125(4):1433-45. (PMID: 25798616) Biochem J. 2008 Jan 1;409(1):205-13. (PMID: 17714076) Nutr Res. 2013 Dec;33(12):1053-62. (PMID: 24267045) J Ethnopharmacol. 2000 Jul;71(1-2):45-53. (PMID: 10904145) Front Genet. 2014 Sep 05;5:279. (PMID: 25250042) Exp Gerontol. 2006 Oct;41(10):928-34. (PMID: 16839734) Ann N Y Acad Sci. 2003 Jun;991:107-10. (PMID: 12846979) |
معلومات مُعتمدة: | 43260 Science, Technology &. Innovation Funding Authority (STDF) |
فهرسة مساهمة: | Keywords: Caenorhabditis elegans; Neuroprotection; Oxidative stress; SKN-1/Nrf2; Styphnolobium japonicum |
المشرفين على المادة: | W6Q80SK9L6 (juglone) 0 (alpha-Synuclein) 0 (Amyloid beta-Peptides) 0 (Plant Extracts) |
تواريخ الأحداث: | Date Created: 20230919 Date Completed: 20230921 Latest Revision: 20231123 |
رمز التحديث: | 20231123 |
مُعرف محوري في PubMed: | PMC10507854 |
DOI: | 10.1186/s12906-023-04149-8 |
PMID: | 37726773 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2662-7671 |
---|---|
DOI: | 10.1186/s12906-023-04149-8 |