دورية أكاديمية
Boerelasins A-D, Four Unprecedented Cytochalasins from the Endophytic Fungus Boeremia Exigua .
| العنوان: | Boerelasins A-D, Four Unprecedented Cytochalasins from the Endophytic Fungus Boeremia Exigua . |
|---|---|
| المؤلفون: | Shi BB; School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan 430074, People's Republic of China., Tian C; School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan 430074, People's Republic of China., Lv X; School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan 430074, People's Republic of China., Schinnerl J; Department of Botany and Biodiversity Research, University of Vienna, Rennweg 14, Vienna A-1030, Austria., Ye K; School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan 430074, People's Republic of China., Guo H; School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan 430074, People's Republic of China., Xu F; School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan 430074, People's Republic of China., He Y; School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan 430074, People's Republic of China., Ai HL; School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan 430074, People's Republic of China., Liu JK; School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan 430074, People's Republic of China. |
| المصدر: | The Journal of organic chemistry [J Org Chem] 2023 Oct 06; Vol. 88 (19), pp. 13926-13933. Date of Electronic Publication: 2023 Sep 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Columbus Oh : American Chemical Society Original Publication: Easton, Pa. [etc.] |
| مستخلص: | Four undescribed cytochalasins ( 1-4 ) were isolated from the endophytic fungus Boeremia exigua . Structurally, boerelasin A ( 1 ) represents the first example of a cytochalasin with a rare 5/5 bicyclic carbon core. Boerelasin B ( 2 ) possesses an unprecedented 5/6/5/6/8 pentacyclic ring system. Boerelasin C ( 3 ), a derivative from the common biosynthetic intermediate to 1 , is a macrocyclic ring-opening cytochalasin, and boerelasin D ( 4 ) contains an uncommon six-carbon alkyl acid side chain. The structures were elucidated based on spectroscopic methods, electronic circular dichroism, spin-spin coupling constants, and calculated nuclear magnetic resonance with DP4+ analysis. These compounds exhibited significant cytotoxicity against the tumor cells. |
| تواريخ الأحداث: | Date Created: 20230920 Latest Revision: 20231006 |
| رمز التحديث: | 20231006 |
| DOI: | 10.1021/acs.joc.3c01515 |
| PMID: | 37728955 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-6904 |
|---|---|
| DOI: | 10.1021/acs.joc.3c01515 |