دورية أكاديمية
Multi-Cancer Early Detection: The New Frontier in Cancer Early Detection.
| العنوان: | Multi-Cancer Early Detection: The New Frontier in Cancer Early Detection. |
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| المؤلفون: | Guerra CE; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; email: carmen.guerra@pennmedicine.upenn.edu.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Leonard David Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Sharma PV; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; email: Prateek.Sharma@pennmedicine.upenn.edu., Castillo BS; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; email: carmen.guerra@pennmedicine.upenn.edu.; Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA; email: Brenda.Castillo@pennmedicine.upenn.edu. |
| المصدر: | Annual review of medicine [Annu Rev Med] 2024 Jan 29; Vol. 75, pp. 67-81. Date of Electronic Publication: 2023 Sep 20. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Annual Reviews Country of Publication: United States NLM ID: 2985151R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-326X (Electronic) Linking ISSN: 00664219 NLM ISO Abbreviation: Annu Rev Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Palo Alto Ca : Annual Reviews Original Publication: Palo Alto, Calif., Annual Reviews, inc. |
| مواضيع طبية MeSH: | Early Detection of Cancer* , Neoplasms*/diagnosis, Humans |
| مستخلص: | The new generation of cancer early detection tests holds remarkable promise for revolutionizing and changing the paradigm of cancer early detection. Dozens of cancer early detection tests are being developed and evaluated. Some are already commercialized and available for use, most as a complement to and not in place of existing recommended cancer screening tests. This review evaluates existing single- and multi-cancer early detection tests (MCEDs), discussing their performance characteristics including sensitivity, specificity, positive and negative predictive values, and accuracy. It also critically looks at the potential harms that could result from these tests, including false positive and negative results, the risk of overdiagnosis and overtreatment, psychological and economic harms, and the risk of widening cancer inequities. We also review the large-scale, population-based studies that are being launched in the United States and United Kingdom to determine the impact of MCEDs on clinically relevant outcomes and implications for current practice. |
| فهرسة مساهمة: | Keywords: MCED; biomarkers; cancer screening; early detection of cancer; liquid biopsy; multi-cancer early detection |
| تواريخ الأحداث: | Date Created: 20230920 Date Completed: 20240130 Latest Revision: 20240130 |
| رمز التحديث: | 20240130 |
| DOI: | 10.1146/annurev-med-050522-033624 |
| PMID: | 37729031 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1545-326X |
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| DOI: | 10.1146/annurev-med-050522-033624 |