دورية أكاديمية
Survivin expression as a prognostic marker for breast cancer.
العنوان: | Survivin expression as a prognostic marker for breast cancer. |
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المؤلفون: | Quidute P; Centro Universitário Faculdade de Medicina do ABC, Laboratório de Análises Clínicas - Santo André (SP), Brazil., Quidute R; Centro Universitário Faculdade de Medicina do ABC, Laboratório de Análises Clínicas - Santo André (SP), Brazil., Perez MM; Centro Universitário Faculdade de Medicina do ABC, Laboratório de Análises Clínicas - Santo André (SP), Brazil., Pereira EC; Universidade Federal de São Paulo, Instituto de Ciências Farmacêuticas - Diadema (SP), Brazil., Veiga GLD; Centro Universitário Faculdade de Medicina do ABC, Laboratório de Análises Clínicas - Santo André (SP), Brazil., Alves BDCA; Centro Universitário Faculdade de Medicina do ABC, Laboratório de Análises Clínicas - Santo André (SP), Brazil., Fonseca FLA; Centro Universitário Faculdade de Medicina do ABC, Laboratório de Análises Clínicas - Santo André (SP), Brazil.; Universidade Federal de São Paulo, Instituto de Ciências Farmacêuticas - Diadema (SP), Brazil. |
المصدر: | Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2023 Sep 18; Vol. 69 (9), pp. e20230167. Date of Electronic Publication: 2023 Sep 18 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Associação Médica Brasileira Country of Publication: Brazil NLM ID: 9308586 Publication Model: eCollection Cited Medium: Internet ISSN: 1806-9282 (Electronic) Linking ISSN: 01044230 NLM ISO Abbreviation: Rev Assoc Med Bras (1992) Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: São Paulo : Associação Médica Brasileira |
مواضيع طبية MeSH: | Breast Neoplasms*, Humans ; Female ; Adult ; Survivin ; Cross-Sectional Studies ; Prognosis ; Receptors, Estrogen |
مستخلص: | Objective: Due to the speed of development observed in breast cancer, several studies aimed at discovering new biomarkers have been carried out in order to arrive at an early diagnosis. As survivin plays a fundamental role in the evasion of apoptosis in tumor cells, the aim of this study was to verify the expression profile of the survivin gene in paraffin-embedded breast tumor samples and associate it with the clinical characteristics of the patients. Methods: This is a cross-sectional study, for which 100 tumor samples were obtained from cancer patients treated throughout the year 2019 at Instituto de Mama do Cariri (Juazeiro do Norte, in the state of Ceará). This study included women over 30 years old who had confirmed breast cancer through anatomopathological examination but excluded those with non-neoplastic breast comorbidities, other neoplasms, or chronic diseases. Survivin gene expression was assessed by quantitative polymerase chain reaction. Results: The expression of survivin is associated with the lack of expression of estrogen (p=0.027) and progesterone (p>0.0005) receptors. It means that survivin expression is higher in patients in which labeling was absent for estrogen receptor and progesterone receptor. Conclusion: Our data reinforce that survivin expression is higher in estrogen receptor-patients, thus representing an additional prognostic tool. |
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المشرفين على المادة: | 0 (Survivin) 0 (Receptors, Estrogen) |
تواريخ الأحداث: | Date Created: 20230920 Date Completed: 20230922 Latest Revision: 20230923 |
رمز التحديث: | 20230923 |
مُعرف محوري في PubMed: | PMC10508893 |
DOI: | 10.1590/1806-9282.20230167 |
PMID: | 37729357 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1806-9282 |
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DOI: | 10.1590/1806-9282.20230167 |