Survivin expression as a prognostic marker for breast cancer.

التفاصيل البيبلوغرافية
العنوان:	Survivin expression as a prognostic marker for breast cancer.
المؤلفون:	Quidute P; Centro Universitário Faculdade de Medicina do ABC, Laboratório de Análises Clínicas - Santo André (SP), Brazil., Quidute R; Centro Universitário Faculdade de Medicina do ABC, Laboratório de Análises Clínicas - Santo André (SP), Brazil., Perez MM; Centro Universitário Faculdade de Medicina do ABC, Laboratório de Análises Clínicas - Santo André (SP), Brazil., Pereira EC; Universidade Federal de São Paulo, Instituto de Ciências Farmacêuticas - Diadema (SP), Brazil., Veiga GLD; Centro Universitário Faculdade de Medicina do ABC, Laboratório de Análises Clínicas - Santo André (SP), Brazil., Alves BDCA; Centro Universitário Faculdade de Medicina do ABC, Laboratório de Análises Clínicas - Santo André (SP), Brazil., Fonseca FLA; Centro Universitário Faculdade de Medicina do ABC, Laboratório de Análises Clínicas - Santo André (SP), Brazil.; Universidade Federal de São Paulo, Instituto de Ciências Farmacêuticas - Diadema (SP), Brazil.
المصدر:	Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2023 Sep 18; Vol. 69 (9), pp. e20230167. Date of Electronic Publication: 2023 Sep 18 (Print Publication: 2023).
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Associação Médica Brasileira Country of Publication: Brazil NLM ID: 9308586 Publication Model: eCollection Cited Medium: Internet ISSN: 1806-9282 (Electronic) Linking ISSN: 01044230 NLM ISO Abbreviation: Rev Assoc Med Bras (1992) Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: São Paulo : Associação Médica Brasileira
مواضيع طبية MeSH:	Breast Neoplasms*, Humans ; Female ; Adult ; Survivin ; Cross-Sectional Studies ; Prognosis ; Receptors, Estrogen
مستخلص:	Objective: Due to the speed of development observed in breast cancer, several studies aimed at discovering new biomarkers have been carried out in order to arrive at an early diagnosis. As survivin plays a fundamental role in the evasion of apoptosis in tumor cells, the aim of this study was to verify the expression profile of the survivin gene in paraffin-embedded breast tumor samples and associate it with the clinical characteristics of the patients. Methods: This is a cross-sectional study, for which 100 tumor samples were obtained from cancer patients treated throughout the year 2019 at Instituto de Mama do Cariri (Juazeiro do Norte, in the state of Ceará). This study included women over 30 years old who had confirmed breast cancer through anatomopathological examination but excluded those with non-neoplastic breast comorbidities, other neoplasms, or chronic diseases. Survivin gene expression was assessed by quantitative polymerase chain reaction. Results: The expression of survivin is associated with the lack of expression of estrogen (p=0.027) and progesterone (p>0.0005) receptors. It means that survivin expression is higher in patients in which labeling was absent for estrogen receptor and progesterone receptor. Conclusion: Our data reinforce that survivin expression is higher in estrogen receptor-patients, thus representing an additional prognostic tool.
References:	Biochim Biophys Acta Mol Basis Dis. 2017 Mar;1863(3):663-673. (PMID: 27915033) Genet Test Mol Biomarkers. 2022 Sep;26(9):411-421. (PMID: 36166738) Mol Cell Biochem. 1999 Dec;202(1-2):53-61. (PMID: 10705995) Appl Immunohistochem Mol Morphol. 2016 Jan;24(1):20-5. (PMID: 26317313) Indian J Med Sci. 2009 Nov;63(11):481-90. (PMID: 20075549) Nucleic Acids Res. 2001 May 1;29(9):e45. (PMID: 11328886) Mol Biol Rep. 2014 Jan;41(1):233-40. (PMID: 24197699) Target Oncol. 2014 Dec;9(4):349-57. (PMID: 24233638) J Exp Clin Cancer Res. 2019 Aug 22;38(1):368. (PMID: 31439015) Nat Med. 1997 Aug;3(8):917-21. (PMID: 9256286) Hum Immunol. 2023 Apr;84(4):301-310. (PMID: 36754653) J Breast Cancer. 2019 Apr 19;22(2):248-259. (PMID: 31281727) Cell Mol Biol Lett. 2017 Apr 5;22:8. (PMID: 28536639) Oral Oncol. 2021 Jan;112:105049. (PMID: 33221541) AJR Am J Roentgenol. 2021 Aug;217(2):278-290. (PMID: 33594908) Cancer Treat Rev. 2021 Nov;100:102286. (PMID: 34534820) Breast Cancer Res. 2020 Jun 9;22(1):61. (PMID: 32517735) Technol Cancer Res Treat. 2021 Jan-Dec;20:1533033820983298. (PMID: 33499770) Biomed Res Int. 2022 Apr 18;2022:9605439. (PMID: 35480139) Surg Oncol. 2012 Jun;21(2):125-31. (PMID: 21334875) J Biol Chem. 2020 Oct 2;295(40):13737-13752. (PMID: 32709750)
المشرفين على المادة:	0 (Survivin) 0 (Receptors, Estrogen)
تواريخ الأحداث:	Date Created: 20230920 Date Completed: 20230922 Latest Revision: 20230923
رمز التحديث:	20230923
مُعرف محوري في PubMed:	PMC10508893
DOI:	10.1590/1806-9282.20230167
PMID:	37729357
قاعدة البيانات:	MEDLINE

Full Text Finder

الوصف
تدمد:	1806-9282
DOI:	10.1590/1806-9282.20230167