دورية أكاديمية
Effects of folate deficiency and sex on carcinogenesis in a mouse model of oral cancer.
العنوان: | Effects of folate deficiency and sex on carcinogenesis in a mouse model of oral cancer. |
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المؤلفون: | Pitstick L; Department of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA., Goral J; Department of Anatomy, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA., Ciancio MJ; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA., Meyer A; Department of Anatomy, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA., Pytynia M; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA., Bychek S; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA., Zidan S; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA., Shuey J; Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois, USA., Jham BC; College of Dental Medicine-Illinois, Midwestern University, Downers Grove, Illinois, USA., Green JM; Department of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA. |
المصدر: | Oral diseases [Oral Dis] 2024 May; Vol. 30 (4), pp. 1989-2003. Date of Electronic Publication: 2023 Sep 20. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9508565 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-0825 (Electronic) Linking ISSN: 1354523X NLM ISO Abbreviation: Oral Dis Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2001- : Copenhagen, Denmark : Munksgaard Original Publication: Houndmills, Basingstoke, Hampshire, UK : Stockton Press, c1995- |
مواضيع طبية MeSH: | Folic Acid Deficiency*/complications , 4-Nitroquinoline-1-oxide* , Mice, Inbred C57BL* , Mouth Neoplasms*/pathology , Mouth Neoplasms*/metabolism , Mouth Neoplasms*/etiology , Disease Models, Animal*, Animals ; Female ; Male ; Mice ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/etiology ; Sex Factors ; Proton-Coupled Folate Transporter/metabolism ; Reduced Folate Carrier Protein/metabolism ; T-Lymphocytes/metabolism ; Carcinogenesis ; Folic Acid ; Cell Proliferation/drug effects ; Macrophages ; Tongue Neoplasms/pathology ; Tongue Neoplasms/metabolism ; Tongue Neoplasms/chemically induced ; Neutrophil Infiltration ; Neutrophils ; Folic Acid Transporters/metabolism |
مستخلص: | Objectives: To investigate the effects of dietary folate and sex on histopathology of oral squamous cell carcinoma in mice. Materials and Methods: Mice (C57Bl/6, 30/sex) were fed either a deficient folate or sufficient folate diet. Vehicle or 4-nitroquinoline1-oxide (50 μg/mL) in vehicle were administered in drinking water for 20 weeks, followed by 6 weeks of regular drinking water. Oral lesions were observed weekly. Tongues were studied for histopathologic changes. Immunohistochemical techniques were used to measure cell proliferation (Ki67+), and to quantify expression of folate receptor, reduced folate carrier, and proton-coupled folate transporter. T cells, macrophages, and neutrophils were counted and normalized to area. Results: All 4NQO-treated mice developed oral tumors. Dietary folate level did not affect tumor burden. More tumors were observed on the ventral aspect of the tongue than in other locations within the oral cavity. 4-nitroquinoline-1-oxide-treated mice displayed 27%-46% significantly lower expression of all three folate transport proteins; diet and sex had no effect on folate transporter expression. T-cell and neutrophil infiltration in tongues were 9.1-fold and 18.1-fold increased in the 4-nitroquinoline-1-oxide-treated mouse tongues than in controls. Conclusion: Treatment with 4NQO was the primary factor in determining cancer development, decreased folate transport expression, and lymphoid cell infiltration. (© 2023 Wiley Periodicals LLC.) |
References: | Alawsi, D. F., Bukhari, A. B., Malhotra, R., & De, A. (2019). The significance of p53, Bcl‐2, and HER‐2/neu protein expression in Iraqi females breast cancer cell line (AMJ13). Indian Journal of Public Health, 10, 181. American Cancer Society. (2018). Cancer facts and figures 2018. American Cancer Society. Bakhtiar, S. M., Ali, A., & Barh, D. (2015). Epigenetics in head and neck cancer. Methods in Molecular Biology, 1238, 751–769. https://doi.org/10.1007/978‐1‐4939‐1804‐1_39. Beydoun, S., Fardous, A. M., Saruna, M. M., Beydoun, A. G., Sorge, J. A., Ma, H., Aoun, G., Unnikrishnan, A., Cabelof, D. C., & Heydari, A. R. (2021). Succinylsulfathiazole modulates the mTOR signaling pathway in the liver of c57BL/6 mice via a folate independent mechanism. Experimental Gerontology, 150, 111387. https://doi.org/10.1016/j.exger.2021.111387. Bhat, A. A., Yousuf, P., Wani, N. A., Rizwan, A., Chauhan, S. S., Siddiqi, M. A., Bedognetti, D., El‐Rifai, W., Frenneaux, M. P., Batra, S. K., Haris, M., & Macha, M. A. (2021). Tumor microenvironment: An evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy. Signal Transduction and Targeted Therapy, 6(1), 12. https://doi.org/10.1038/s41392‐020‐00419‐w. Binnewies, M., Roberts, E. W., Kersten, K., Chan, V., Fearon, D. F., Merad, M., Coussens, L. M., Gabrilovich, D. I., Ostrand‐Rosenberg, S., Hedrick, C. C., Vonderheide, R. H., & Krummel, M. F. (2018). Understanding the tumor immune microenvironment (TIME) for effective therapy. Nature Medicine, 24(5), 541–550. https://doi.org/10.1038/s41591‐018‐0014‐x. Bo, Y., Zhu, Y., Tao, Y., Li, X., Zhai, D., Bu, Y., Wan, Z., Wang, L., Wang, Y., & Yu, Z. (2020). Association between folate and health outcomes: An umbrella review of meta‐analyses. Frontiers in Public Health, 8, 550753. https://doi.org/10.3389/fpubh.2020.550753. Bonomi, M., Patsias, A., Posner, M., & Sikora, A. (2014). The role of inflammation in head and neck cancer. Advances in Experimental Medicine and Biology, 816, 107–127. https://doi.org/10.1007/978‐3‐0348‐0837‐8_5. Boscolo‐Rizzo, P., Furlan, C., Lupato, V., Polesel, J., & Fratta, E. (2017). Novel insights into epigenetic drivers of oropharyngeal squamous cell carcinoma: Role of HPV and lifestyle factors. Clinical Epigenetics, 9, 124. https://doi.org/10.1186/s13148‐017‐0424‐5. Centers for Disease Control and Prevention. (2018). Behavioral risk factor surveillance system survey data. US Department of Health and Human Services, CDC Retrieved from https://chronicdata.cdc.gov/Behavioral‐Risk‐Factors/Behavioral‐Risk‐Factor‐Surveillance‐System‐BRFSS‐H/iuq5‐y9ct. Chanmee, T., Ontong, P., Konno, K., & Itano, N. (2014). Tumor‐associated macrophages as major players in the tumor microenvironment. Cancers (Basel), 6(3), 1670–1690. https://doi.org/10.3390/cancers6031670. Chu, M., Su, Y. X., Wang, L., Zhang, T. H., Liang, Y. J., Liang, L. Z., & Liao, G. Q. (2012). Myeloid‐derived suppressor cells contribute to oral cancer progression in 4NQO‐treated mice. Oral Diseases, 18(1), 67–73. https://doi.org/10.1111/j.1601‐0825.2011.01846.x. Ciappio, E., & Mason, J. B. (2010). Folate and carcinogenesis. In L. J. Bailey (Ed.), Folate in health and disease (pp. 235–262). CRC Press. Cole, B. F., Baron, J. A., Sandler, R. S., Haile, R. W., Ahnen, D. J., Bresalier, R. S., McKeown‐Eyssen, G., Summers, R. W., Rothstein, R. I., Burke, C. A., Snover, D. C., Church, T. R., Allen, J. I., Robertson, D. J., Beck, G. J., Bond, J. H., Byers, T., Mandel, J. S., Mott, L. A., … Greenberg, E. R. (2007). Folic acid for the prevention of colorectal adenomas: A randomized clinical trial. JAMA, 297(21), 2351–2359. https://doi.org/10.1001/jama.297.21.2351. Crider, K. S., Yang, T. P., Berry, R. J., & Bailey, L. B. (2012). Folate and DNA methylation: A review of molecular mechanisms and the evidence for folate's role. Advances in Nutrition, 3(1), 21–38. https://doi.org/10.3945/an.111.000992000992. Crowe, A. R., & Yue, W. (2019). Semi‐quantitative determination of protein expression using immunohistochemistry staining and analysis: An integrated protocol. Bio‐Protocol, 9(24), e3465. https://doi.org/10.21769/BioProtoc.3465. Czerninski, R., Amornphimoltham, P., Patel, V., Molinolo, A. A., & Gutkind, J. S. (2009). Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral‐specific chemical carcinogenesis model. Cancer Prevention Research (Philadelphia, Pa.), 2(1), 27–36. https://doi.org/10.1158/1940‐6207.capr‐08‐0147. Danella, E. B., Costa de Medeiros, M., & D'Silva, N. J. (2023). Cytokines secreted by inflamed oral mucosa: Implications for oral cancer progression. Oncogene, 42, 1159–1165. https://doi.org/10.1038/s41388‐023‐02649‐y. Duthie, S. J. (2011). Folate and cancer: How DNA damage, repair and methylation impact on colon carcinogenesis. Journal of Inherited Metabolic Disease, 34(1), 101–109. https://doi.org/10.1007/s10545‐010‐9128‐0. Ehrlich, M. (2002). DNA methylation in cancer: Too much, but also too little. Oncogene, 21(35), 5400–5413. https://doi.org/10.1038/sj.onc.1205651. Erugula, S. R., Kandukuri, M. K., Danappanavar, P. M., Ealla, K. K., Velidandla, S., & Manikya, S. (2016). Clinical utility of serum homocysteine and folate as tumor markers in Oral squamous cell carcinoma ‐ a cross‐sectional study. Journal of Clinical and Diagnostic Research, 10(10), Zc24–zc28. https://doi.org/10.7860/jcdr/2016/19656.8637. Fanidi, A., Relton, C., Ueland, P. M., Midttun, O., Vollset, S. E., Travis, R. C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Bueno‐de‐Mesquita, H. B., Ros, M., Boeing, H., Tumino, R., Panico, S., Palli, D., Sieri, S., Vineis, P., Sánchez, M.‐J., Huerta, J. M., … Johansson, M. (2015). A prospective study of one‐carbon metabolism biomarkers and cancer of the head and neck and esophagus. International Journal of Cancer, 136(4), 915–927. https://doi.org/10.1002/ijc.29051. Faraji, F., Rettig, E. M., Tsai, H. L., El Asmar, M., Fung, N., Eisele, D. W., & Fakhry, C. (2019). The prevalence of human papillomavirus in oropharyngeal cancer is increasing regardless of sex or race, and the influence of sex and race on survival is modified by human papillomavirus tumor status. Cancer, 125(5), 761–769. https://doi.org/10.1002/cncr.31841. Feller, L., Altini, M., & Lemmer, J. (2013). Inflammation in the context of oral cancer. Oral Oncology, 49(9), 887–892. https://doi.org/10.1016/j.oraloncology.2013.07.003. Galdiero, M. R., Garlanda, C., Jaillon, S., Marone, G., & Mantovani, A. (2013). Tumor associated macrophages and neutrophils in tumor progression. Journal of Cellular Physiology, 228(7), 1404–1412. https://doi.org/10.1002/jcp.24260. Ge, W., Jiao, Y., & Chang, L. (2018). The association between MTHFR gene polymorphisms (C677T, A1298C) and oral squamous cell carcinoma: A systematic review and meta‐analysis. PLoS One, 13(8), e0202959. https://doi.org/10.1371/journal.pone.0202959. Gerdes, J. (1990). Ki‐67 and other proliferation markers useful for immunohistological diagnostic and prognostic evaluations in human malignancies. Seminars in Cancer Biology, 1(3), 199–206. Gillison, M. L., Broutian, T., Pickard, R. K., Tong, Z. Y., Xiao, W., Kahle, L., Graubard, B. I., & Chaturvedi, A. K. (2012). Prevalence of oral HPV infection in the United States, 2009–2010. JAMA, 307(7), 693–703. https://doi.org/10.1001/jama.2012.101. Goral, J., Cuadros, K., Pitstick, L., Meyer, A., Jham, B. C., Guimaraes, E. P., Hanemann, J. A. C., & Green, J. M. (2019). Decreased expression of folate transport proteins in oral cancer. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 127(5), 417–424. https://doi.org/10.1016/j.oooo.2018.09.005. Green, J. M., Ciancio, M. J., Goral, J., Pytynia, M., Pitstick, L., Meyer, A., Nguyen, A., Lee, K., Barakat, A., & Jham, B. C. (2021). Dietary fat and male sex increase histopathological changes in a mouse model of oral cancer. Oral Diseases, 27(2), 215–225. https://doi.org/10.1111/odi.13542. Grivennikov, S. I., Greten, F. R., & Karin, M. (2010). Immunity, inflammation, and cancer. Cell, 140(6), 883–899. https://doi.org/10.1016/j.cell.2010.01.025. Guenther, B. D., Sheppard, C. A., Tran, P., Rozen, R., Matthews, R. G., & Ludwig, M. L. (1999). The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. Nature Structural Biology, 6(4), 359–365. https://doi.org/10.1038/7594. Hadjigol, S., Shah, B. A., & O'Brien‐Simpson, N. M. (2022). The 'Danse Macabre'‐neutrophils the interactive partner affecting Oral cancer outcomes. Frontiers in Immunology, 13, 894021. https://doi.org/10.3389/fimmu.2022.894021. Hashibe, M., Brennan, P., Chuang, S. C., Boccia, S., Castellsague, X., Chen, C., Curado, M. P., Dal Maso, L., Daudt, A. W., Fabianova, E., Fernandez, L., Wünsch‐Filho, V., Franceschi, S., Hayes, R. B., Herrero, R., Kelsey, K., Koifman, S., La Vecchia, C., Lazarus, P., … Boffetta, P. (2009). Interaction between tobacco and alcohol use and the risk of head and neck cancer: Pooled analysis in the international head and neck cancer epidemiology consortium. Cancer Epidemiology, Biomarkers and Prevention, 18(2), 541–550. https://doi.org/10.1158/1055‐9965.EPI‐08‐0347. Hazra, A., Selhub, J., Chao, W. H., Ueland, P. M., Hunter, D. J., & Baron, J. A. (2010). Uracil misincorporation into DNA and folic acid supplementation. The American Journal of Clinical Nutrition, 91(1), 160–165. https://doi.org/10.3945/ajcn.2009.28527. Hsiung, D. T., Marsit, C. J., Houseman, E. A., Eddy, K., Furniss, C. S., McClean, M. D., & Kelsey, K. T. (2007). Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. Cancer Epidemiology, Biomarkers and Prevention, 16(1), 108–114. https://doi.org/10.1158/1055‐9965.epi‐06‐0636. Jamal, A., Phillips, E., Gentzke, A. S., Homa, D. M., Babb, S. D., King, B. A., & Neff, L. J. (2018). Current cigarette smoking among adults ‐ United States, 2016. MMWR. Morbidity and Mortality Weekly Report, 67(2), 53–59. https://doi.org/10.15585/mmwr.mm6702a1. Keeley, T., Costanzo‐Garvey, D. L., & Cook, L. M. (2019). Unmasking the many faces of tumor‐associated neutrophils and macrophages: Considerations for targeting innate immune cells in cancer. Trends Cancer, 5(12), 789–798. https://doi.org/10.1016/j.trecan.2019.10.013. Kim, Y. I. (1999). Folate and carcinogenesis: Evidence, mechanisms, and implications. The Journal of Nutritional Biochemistry, 10(2), 66–88. https://doi.org/10.1016/s0955‐2863(98)00074‐6. Kolb, A. F., & Petrie, L. (2013). Folate deficiency enhances the inflammatory response of macrophages. Molecular Immunology, 54(2), 164–172. https://doi.org/10.1016/j.molimm.2012.11.012. Kumar, V., Donthireddy, L., Marvel, D., Condamine, T., Wang, F., Lavilla‐Alonso, S., Hashimoto, A., Vonteddu, P., Behera, R., Goins, M. A., Mulligan, C., Nam, B., Hockstein, N., Denstman, F., Shakamuri, S., Speicher, D. W., Weeraratna, A. T., Chao, T., Vonderheide, R. H., … Gabrilovich, D. I. (2017). Cancer‐associated fibroblasts neutralize the anti‐tumor effect of CSF1 receptor blockade by inducing PMN‐MDSC infiltration of tumors. Cancer Cell, 32(5), 654–668. https://doi.org/10.1016/j.ccell.2017.10.005. Langevin, S. M., Grandis, J. R., & Taioli, E. (2011). Female hormonal and reproductive factors and head and neck squamous cell carcinoma risk. Cancer Letters, 310(2), 216–221. https://doi.org/10.1016/j.canlet.2011.07.007. Lindsay, C., Seikaly, H., & Biron, V. L. (2017). Epigenetics of oropharyngeal squamous cell carcinoma: Opportunities for novel chemotherapeutic targets. Journal of Otolaryngology ‐ Head and Neck Surgery, 46(1), 9. https://doi.org/10.1186/s40463‐017‐0185‐3. Linhart, H. G., Troen, A., Bell, G. W., Cantu, E., Chao, W. H., Moran, E., Steine, E., He, T., & Jaenisch, R. (2009). Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations. Gastroenterology, 136(1), 227–235. https://doi.org/10.1053/j.gastro.2008.10.016. Ly, A., Hoyt, L., Crowell, J., & Kim, Y. I. (2012). Folate and DNA methylation. Antioxidants and Redox Signaling, 17(2), 302–326. https://doi.org/10.1089/ars.2012.4554. Martell, B. N., Garrett, B. E., & Caraballo, R. S. (2016). Disparities in adult cigarette smoking ‐ United States, 2002–2005 and 2010–2013. MMWR. Morbidity and Mortality Weekly Report, 65(30), 753–758. https://doi.org/10.15585/mmwr.mm6530a1. Marur, S., & Forastiere, A. A. (2016). Head and neck squamous cell carcinoma: Update on epidemiology, diagnosis, and treatment. Mayo Clinic Proceedings, 91(3), 386–396. https://doi.org/10.1016/j.mayocp.2015.12.017S0025‐6196(15)01006‐X. Mason, J. B., Dickstein, A., Jacques, P. F., Haggarty, P., Selhub, J., Dallal, G., & Rosenberg, I. H. (2007). A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: A hypothesis. Cancer Epidemiology, Biomarkers and Prevention, 16(7), 1325–1329. https://doi.org/10.1158/1055‐9965.epi‐07‐0329. Mazilu, L., Suceveanu, A. I., Stanculeanu, D. L., Gheorghe, A. D., Fricatel, G., & Negru, S. M. (2021). Tumor microenvironment is not an 'innocent bystander' in the resistance to treatment of head and neck cancers (review). Experimental and Therapeutic Medicine, 22(4), 1128. https://doi.org/10.3892/etm.2021.10562. Molloy, A. M., & Scott, J. M. (1997). Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method. Methods in Enzymology, 281, 43–53. https://doi.org/10.1016/s0076‐6879(97)81007‐5. Munn, L. L. (2017). Cancer and inflammation. Wiley Interdisciplinary Reviews. Systems Biology and Medicine, 9(2), e1370. https://doi.org/10.1002/wsbm.1370. Nguyen, D. H., Zhou, T., Shu, J., & Mao, J. H. (2013). Quantifying chromogen intensity in immunohistochemistry via reciprocal intensity. Cancer InCytes, 2(1), pp. 1–4. Paludetti, G., Almadori, G., Bussu, F., Galli, J., Cadoni, G., & Maurizi, M. (2005). Hypofolatemia as a risk factor for head and neck cancer. Advances in Oto‐Rhino‐Laryngology, 62, 12–24. https://doi.org/10.1159/000082459. Pejchal, R., Campbell, E., Guenther, B. D., Lennon, B. W., Matthews, R. G., & Ludwig, M. L. (2006). Structural perturbations in the ala → Val polymorphism of methylenetetrahydrofolate reductase: How binding of folates may protect against inactivation. Biochemistry, 45(15), 4808–4818. https://doi.org/10.1021/bi052294c. Peng, Y., Dong, B., & Wang, Z. (2016). Serum folate concentrations and all‐cause, cardiovascular disease and cancer mortality: A cohort study based on 1999–2010 National Health and nutrition examination survey (NHANES). International Journal of Cardiology, 219, 136–142. https://doi.org/10.1016/j.ijcard.2016.06.024. Pezzuto, F., Buonaguro, L., Caponigro, F., Ionna, F., Starita, N., Annunziata, C., Buonaguro, F. M., & Tornesello, M. L. (2015). Update on head and neck cancer: Current knowledge on epidemiology, risk factors, molecular features and novel therapies. Oncology, 89(3), 125–136. https://doi.org/10.1159/000381717. Pieroth, R., Paver, S., Day, S., & Lammersfeld, C. (2018). Folate and its impact on cancer risk. Current Nutrition Reports, 7(3), 70–84. https://doi.org/10.1007/s13668‐018‐0237‐y. Qu, Y., He, Y., Ruan, H., Qin, L., & Han, Z. (2023). Abnormal downregulation of 10‐formyltetrahydrofolate dehydrogenase promotes the progression of oral squamous cell carcinoma by activating PI3K/Akt/Rb pathway. Cancer Medicine, 12(5), 5781–5797. https://doi.org/10.1002/cam4.5327. Rad, H. S., Shiravand, Y., Radfar, P., Ladwa, R., Perry, C., Han, X., Warkiani, M. E., Adams, M. N., Hughes, B. G., O'Byrne, K., & Kulasinghe, A. (2022). Understanding the tumor microenvironment in head and neck squamous cell carcinoma. Clinical and Translational Immunology, 11(6), e1397. https://doi.org/10.1002/cti2.1397. Ramaswamy, G., Rao, V. R., Kumaraswamy, S. V., & Anantha, N. (1996). Serum vitamins' status in oral leucoplakias—A preliminary study. European Journal of Cancer. Part B, Oral Oncology, 32b, 120–122. https://doi.org/10.1016/0964‐1955(95)00076‐3. Raval, G. N., Sainger, R. N., Rawal, R. M., Patel, J. B., Patel, B. P., Jha, F. P., Patel, D. D., & Patel, P. S. (2002). Vitamin B(12) and folate status in head and neck cancer. Asian Pacific Journal of Cancer Prevention, 3(2), 155–162. Rethman, M. P., Carpenter, W., Cohen, E. E., Epstein, J., Evans, C. A., Flaitz, C. M., Graham, F. J., Hujoel, P. P., Kalmar, J. R., Koch, W. M., Lambert, P. M., & Meyer, D. M. (2010). Evidence‐based clinical recommendations regarding screening for oral squamous cell carcinomas. Journal of the American Dental Association (1939), 141(5), 509–520. https://doi.org/10.14219/jada.archive.2010.0223. Ruffin, A. T., Li, H., Vujanovic, L., Zandberg, D. P., Ferris, R. L., & Bruno, T. C. (2023). Improving head and neck cancer therapies by immunomodulation of the tumour microenvironment. Nature Reviews. Cancer, 23(3), 173–188. https://doi.org/10.1038/s41568‐022‐00531‐9. Rumgay, H., Murphy, N., Ferrari, P., & Soerjomataram, I. (2021). Alcohol and cancer: Epidemiology and biological mechanisms. Nutrients, 13(9), 3173. https://doi.org/10.3390/nu13093173. Sauer, J., Mason, J. B., & Choi, S. W. (2009). Too much folate: A risk factor for cancer and cardiovascular disease? Current Opinion in Clinical Nutrition and Metabolic Care, 12(1), 30–36. https://doi.org/10.1097/MCO.0b013e32831cec62. Schietinger, A., Philip, M., Krisnawan, V. E., Chiu, E. Y., Delrow, J. J., Basom, R. S., Lauer, P., Brockstedt, D. G., Knoblaugh, S. E., Hämmerling, G. J., Schell, T. D., & Greenberg, P. D. (2016). Tumor‐specific T cell dysfunction is a dynamic antigen‐driven differentiation program initiated early during tumorigenesis. Immunity, 45(2), 389–401. https://doi.org/10.1016/j.immuni.2016.07.011. Schoop, R. A., Noteborn, M. H., & Baatenburg de Jong, R. J. (2009). A mouse model for oral squamous cell carcinoma. Journal of Molecular Histology, 40(3), 177–181. https://doi.org/10.1007/s10735‐009‐9228‐z. Sim, F., Leidner, R., & Bell, R. B. (2019). Immunotherapy for head and neck cancer. Hematology/Oncology Clinics of North America, 33(2), 301–321. https://doi.org/10.1016/j.hoc.2018.12.006. Spitz, M. R. (1994). Epidemiology and risk factors for head and neck cancer. Seminars in Oncology, 21(3), 281–288. Stolzenberg‐Solomon, R. Z., Chang, S. C., Leitzmann, M. F., Johnson, K. A., Johnson, C., Buys, S. S., Hoover, R. N., & Ziegler, R. G. (2006). Folate intake, alcohol use, and postmenopausal breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial. The American Journal of Clinical Nutrition, 83(4), 895–904. https://doi.org/10.1093/ajcn/83.4.895. Stover, P. J. (2010). Folate biochemical pathways and their regulation. In L. B. Bailey (Ed.), Folate in health and disease (2nd ed., pp. 49–74). CRC Press. Su, W. W., Su, C. W., Chang, D. C., Chuang, S. L., Chen, S. L., Hsu, C. Y., Yen, A. M. F., Chiu, S. Y. H., Fann, J. C. Y., Lee, Y. H., Jeng, Y. C., & Chen, M. K. (2019). Impact of varying anatomic sites on advanced stage and survival of oral cancer: 9‐year prospective cohort of 27 717 cases. Head and Neck, 41(5), 1475–1483. https://doi.org/10.1002/hed.25579. Tham, T., Wotman, M., Roche, A., Kraus, D., & Costantino, P. (2019). The prognostic effect of anatomic subsite in HPV‐positive oropharyngeal squamous cell carcinoma. American Journal of Otolaryngology, 40(4), 567–572. https://doi.org/10.1016/j.amjoto.2019.05.006. Thomson, B., Emberson, J., Lacey, B., Lewington, S., Peto, R., Jemal, A., & Islami, F. (2022). Association between smoking, smoking cessation, and mortality by race, ethnicity, and sex among US adults. JAMA Network Open, 5(10), e2231480. https://doi.org/10.1001/jamanetworkopen.2022.31480. Varghese, F., Bukhari, A. B., Malhotra, R., & De, A. (2014). IHC profiler: An open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples. PLoS One, 9(5), e96801. https://doi.org/10.1371/journal.pone.0096801. Wang, H. F., Jiang, J., Wu, J. S., Zhang, M., Pang, X., Dai, L., Tang, Y. L., & Liang, X. H. (2022). Hypermethylation of PRKCZ regulated by E6 inhibits invasion and EMT via Cdc42 in HPV‐related head and neck squamous cell carcinoma. Cancers (Basel), 14(17), 4151. https://doi.org/10.3390/cancers14174151. Warnakulasuriya, S. (2009). Global epidemiology of oral and oropharyngeal cancer. Oral Oncology, 45(4–5), 309–316. https://doi.org/10.1016/j.oraloncology.2008.06.002. Wherry, E. J. (2011). T cell exhaustion. Nature Immunology, 12(6), 492–499. https://doi.org/10.1038/ni.2035. Willimsky, G., & Blankenstein, T. (2005). Sporadic immunogenic tumours avoid destruction by inducing T‐cell tolerance. Nature, 437(7055), 141–146. https://doi.org/10.1038/nature03954. Xiang, Y., Gong, M., Deng, Y., Wang, H., & Ye, D. (2023). T cell effects and mechanisms in immunotherapy of head and neck tumors. Cell Communication and Signaling: CCS, 21(1), 49. https://doi.org/10.1186/s12964‐023‐01070‐y. Yang, Q., Bostick, R. M., Friedman, J. M., & Flanders, W. D. (2009). Serum folate and cancer mortality among U.S. adults: Findings from the third National Health and nutritional examination survey linked mortality file. Cancer Epidemiology, Biomarkers and Prevention, 18(5), 1439–1447. https://doi.org/10.1158/1055‐9965.epi‐08‐0908. Zhu, L., Wang, Y., Yuan, X., Ma, Y., Zhang, T., Zhou, F., & Yu, G. (2022). Effects of immune inflammation in head and neck squamous cell carcinoma: Tumor microenvironment, drug resistance, and clinical outcomes. Frontiers in Genetics, 13, 1085700. https://doi.org/10.3389/fgene.2022.1085700. |
معلومات مُعتمدة: | Midwestern University funded this work. |
فهرسة مساهمة: | Keywords: 4NQO; 4‐Nitroquinoline‐1‐oxide; folate deficiency; folate transporter; inflammation; mouse model; oral cancer; oral squamous cell carcinoma |
المشرفين على المادة: | 56-57-5 (4-Nitroquinoline-1-oxide) 0 (Proton-Coupled Folate Transporter) 0 (Reduced Folate Carrier Protein) 935E97BOY8 (Folic Acid) 0 (Folic Acid Transporters) |
تواريخ الأحداث: | Date Created: 20230921 Date Completed: 20240531 Latest Revision: 20240703 |
رمز التحديث: | 20240703 |
DOI: | 10.1111/odi.14728 |
PMID: | 37731277 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1601-0825 |
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DOI: | 10.1111/odi.14728 |