دورية أكاديمية
أعرض في EDS

Effects of folate deficiency and sex on carcinogenesis in a mouse model of oral cancer.

التفاصيل البيبلوغرافية
العنوان: Effects of folate deficiency and sex on carcinogenesis in a mouse model of oral cancer.
المؤلفون: Pitstick L; Department of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA., Goral J; Department of Anatomy, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA., Ciancio MJ; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA., Meyer A; Department of Anatomy, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA., Pytynia M; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA., Bychek S; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA., Zidan S; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA., Shuey J; Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois, USA., Jham BC; College of Dental Medicine-Illinois, Midwestern University, Downers Grove, Illinois, USA., Green JM; Department of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA.
المصدر: Oral diseases [Oral Dis] 2024 May; Vol. 30 (4), pp. 1989-2003. Date of Electronic Publication: 2023 Sep 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9508565 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-0825 (Electronic) Linking ISSN: 1354523X NLM ISO Abbreviation: Oral Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: 2001- : Copenhagen, Denmark : Munksgaard
Original Publication: Houndmills, Basingstoke, Hampshire, UK : Stockton Press, c1995-
مواضيع طبية MeSH: Folic Acid Deficiency*/complications , 4-Nitroquinoline-1-oxide* , Mice, Inbred C57BL* , Mouth Neoplasms*/pathology , Mouth Neoplasms*/metabolism , Mouth Neoplasms*/etiology , Disease Models, Animal*, Animals ; Female ; Male ; Mice ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/etiology ; Sex Factors ; Proton-Coupled Folate Transporter/metabolism ; Reduced Folate Carrier Protein/metabolism ; T-Lymphocytes/metabolism ; Carcinogenesis ; Folic Acid ; Cell Proliferation/drug effects ; Macrophages ; Tongue Neoplasms/pathology ; Tongue Neoplasms/metabolism ; Tongue Neoplasms/chemically induced ; Neutrophil Infiltration ; Neutrophils ; Folic Acid Transporters/metabolism
مستخلص: Objectives: To investigate the effects of dietary folate and sex on histopathology of oral squamous cell carcinoma in mice.
Materials and Methods: Mice (C57Bl/6, 30/sex) were fed either a deficient folate or sufficient folate diet. Vehicle or 4-nitroquinoline1-oxide (50 μg/mL) in vehicle were administered in drinking water for 20 weeks, followed by 6 weeks of regular drinking water. Oral lesions were observed weekly. Tongues were studied for histopathologic changes. Immunohistochemical techniques were used to measure cell proliferation (Ki67+), and to quantify expression of folate receptor, reduced folate carrier, and proton-coupled folate transporter. T cells, macrophages, and neutrophils were counted and normalized to area.
Results: All 4NQO-treated mice developed oral tumors. Dietary folate level did not affect tumor burden. More tumors were observed on the ventral aspect of the tongue than in other locations within the oral cavity. 4-nitroquinoline-1-oxide-treated mice displayed 27%-46% significantly lower expression of all three folate transport proteins; diet and sex had no effect on folate transporter expression. T-cell and neutrophil infiltration in tongues were 9.1-fold and 18.1-fold increased in the 4-nitroquinoline-1-oxide-treated mouse tongues than in controls.
Conclusion: Treatment with 4NQO was the primary factor in determining cancer development, decreased folate transport expression, and lymphoid cell infiltration.
(© 2023 Wiley Periodicals LLC.)
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معلومات مُعتمدة: Midwestern University funded this work.
فهرسة مساهمة: Keywords: 4NQO; 4‐Nitroquinoline‐1‐oxide; folate deficiency; folate transporter; inflammation; mouse model; oral cancer; oral squamous cell carcinoma
المشرفين على المادة: 56-57-5 (4-Nitroquinoline-1-oxide)
0 (Proton-Coupled Folate Transporter)
0 (Reduced Folate Carrier Protein)
935E97BOY8 (Folic Acid)
0 (Folic Acid Transporters)
تواريخ الأحداث: Date Created: 20230921 Date Completed: 20240531 Latest Revision: 20240703
رمز التحديث: 20240703
DOI: 10.1111/odi.14728
PMID: 37731277
قاعدة البيانات: MEDLINE
الوصف
تدمد:1601-0825
DOI:10.1111/odi.14728