دورية أكاديمية
أعرض في EDS

Effect of Ramadan fasting on thyroid functions in hypothyroid patients taking levothyroxine: a systematic review and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Effect of Ramadan fasting on thyroid functions in hypothyroid patients taking levothyroxine: a systematic review and meta-analysis.
المؤلفون: Belal MM; Faculty of Medicine, Alexandria University, Alexandria, Egypt., Youssef AR; Faculty of Medicine, Alexandria University, Alexandria, Egypt., Baker H; Faculty of Medicine, Alexandria University, Alexandria, Egypt., Elalaky NA; Faculty of Medicine, Alexandria University, Alexandria, Egypt., Marey AA; Faculty of Medicine, Alexandria University, Alexandria, Egypt., Quaisy MA; Faculty of Medicine, Alexandria University, Alexandria, Egypt., Rabea EM; Faculty of Medicine, Alexandria University, Alexandria, Egypt. eslam.abd-elmonem1783@alexmed.edu.eg.
المصدر: Irish journal of medical science [Ir J Med Sci] 2024 Apr; Vol. 193 (2), pp. 741-753. Date of Electronic Publication: 2023 Sep 21.
نوع المنشور: Meta-Analysis; Systematic Review; Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Royal Academy of Medicine of Ireland Country of Publication: Ireland NLM ID: 7806864 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1863-4362 (Electronic) Linking ISSN: 00211265 NLM ISO Abbreviation: Ir J Med Sci
أسماء مطبوعة: Original Publication: Dublin : Royal Academy of Medicine of Ireland
مواضيع طبية MeSH: Fasting*/blood , Hypothyroidism*/drug therapy , Thyroxine*/therapeutic use , Islam*, Humans ; Thyroid Gland/physiopathology ; Thyroid Gland/drug effects ; Thyrotropin/blood
مستخلص: Background: The major changes in the timing of meals during Ramadan may be challenging for hypothyroid patients on levothyroxine. We aimed to study the effect of Ramadan fasting on thyroid functions in hypothyroid patients taking levothyroxine.
Methods: We did a comprehensive search of 8 databases for Randomized controlled studies (RCTs) and observational studies investigating the effect of Ramadan fasting on thyroid functions in hypothyroid individuals taking levothyroxine. Relevant data was extracted and analyzed. Mean difference (MD) and standard deviation (SD) were used to evaluate the continuous data. Risk ratios (RR) with a 95% confidence interval were used for outcomes constituting dichotomous data. National Institutes of Health (NIH) tools were used to assess the risk of bias.
Results: Fourteen studies met our inclusion criteria, 3 RCTs, and 11 observational studies, all designed as pre-post studies. Ramadan fasting was associated with a statistically significant increase in TSH in patients who were euthyroid before Ramadan (MD = -0.76 [95% CI; -1.27, -0.25]). However, free thyroxine (FT4) was found to be stable (MD = 0.01, [95% CI; -0.03, 0.06]). All timing points were associated with a significant increase in TSH levels after Ramadan, pre-iftar (MD = -0.69 [95% CI; -1.03, -0.36]), post-iftar (MD = -0.76 [95% CI; -1.12, -0.39]), and pre-suhoor (MD = -1.19 [95% CI; -2.18, -0.19]).
Conclusion: TSH increases significantly after Ramadan. No timing point has superiority in maintaining thyroid control. However, choosing the timing should be individualized according to the patient's preference to guarantee the most possible compliance.
(© 2023. The Author(s).)
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فهرسة مساهمة: Keywords: Fasting; Hypothyroidism; Levothyroxine; Ramadan; TSH
المشرفين على المادة: Q51BO43MG4 (Thyroxine)
9002-71-5 (Thyrotropin)
تواريخ الأحداث: Date Created: 20230921 Date Completed: 20240807 Latest Revision: 20240807
رمز التحديث: 20240808
مُعرف محوري في PubMed: PMC10961289
DOI: 10.1007/s11845-023-03526-z
PMID: 37733226
قاعدة البيانات: MEDLINE
الوصف
تدمد:1863-4362
DOI:10.1007/s11845-023-03526-z