دورية أكاديمية
Antineoplastic therapy in childhood cancer patients presents a negative impact in the periodontal tissues: a cohort study.
العنوان: | Antineoplastic therapy in childhood cancer patients presents a negative impact in the periodontal tissues: a cohort study. |
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المؤلفون: | Longo BC; Department of Dentistry, State University of Maringá (UEM), Av. Mandacaru, 1550, Campus Universitário, Maringá, Paraná, Brazil., Rohling IB; Department of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, Paraná, Brazil., Silva PLMOE; Department of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, Paraná, Brazil., de Morais MEF; Department of Dentistry, State University of Maringá (UEM), Av. Mandacaru, 1550, Campus Universitário, Maringá, Paraná, Brazil., Paz HES; Department of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil., Casarin RCV; Department of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil., Nishiyama SAB; Department of Basic Health Sciences, State University of Maringá (UEM), Maringá, Paraná, Brazil., de Souza MDB; Department of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, Paraná, Brazil., Silva CO; Department of Dentistry, State University of Maringá (UEM), Av. Mandacaru, 1550, Campus Universitário, Maringá, Paraná, Brazil. prof.cleversonsilva@gmail.com. |
المصدر: | Clinical oral investigations [Clin Oral Investig] 2023 Nov; Vol. 27 (11), pp. 6637-6644. Date of Electronic Publication: 2023 Sep 22. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 9707115 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1436-3771 (Electronic) Linking ISSN: 14326981 NLM ISO Abbreviation: Clin Oral Investig |
أسماء مطبوعة: | Publication: Berlin : Springer-Verlag Original Publication: Berlin : Springer, c1997- |
مواضيع طبية MeSH: | Neoplasms*/drug therapy , Periodontitis*/microbiology , Gingivitis*/microbiology , Antineoplastic Agents*/pharmacology, Humans ; Child ; Adolescent ; Cohort Studies ; Periodontal Pocket/microbiology ; Porphyromonas gingivalis ; Fusobacterium nucleatum ; Aggregatibacter actinomycetemcomitans |
مستخلص: | Objectives: To investigate the effect of antineoplastic therapy (AT) in the periodontal tissues of childhood cancer (CC) patients. Materials and Methods: Seventy-two individuals were divided into CC (n=36) and healthy individuals (control group-CG, n=36). Demographics, hygiene habits, CC type, and AT were collected. Salivary flow and the presence and concentration of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, and Fusobacterium nucleatum were analyzed. Clinical evaluation included plaque (PI) and gingival indexes (GI), periodontal probing depth (PPD), and clinical attachment level (CAL). Patients were classified into periodontal health, gingivitis, or periodontitis. Descriptive statistics, T test, Mann-Whitney test, chi-square, Fisher's exact test, and two-way analysis of variance were used (p<0.05). Results: The mean age of the patients was similar (CC 12.0±3.9 years and CG 12.0±4.0 years). In the CC group, all patients underwent chemotherapy and nine radiotherapy. Color/race, income, and family education showed significant differences between groups. There was no difference between groups in salivary flow. Higher levels of Fusobacterium nucleatum were seen in CC (p=0.02). Significant difference between groups was found for PI (CC: 30.5%, CG: 22.6%), GI (CC: 28.8%, CG: 17.3%), PPD (CC: 1.77 mm, CG: 1.61 mm), and CAL (CC: 1.77 mm, CG: 1.57 mm), periodontal health (CC: 3, CG: 7), gingivitis (CC: 16, CG: 24), or periodontitis (CC: 17, CG: 5). Conclusion: AT in CC patients presents a negative impact in the periodontal and microbiological parameters. Clinical Relevance: Childhood cancer individuals showed worse periodontal parameters and higher levels of Fusobacterium nucleatum in the saliva when compared to healthy individuals. (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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فهرسة مساهمة: | Keywords: Antineoplastic protocols; Cancer survivors; Fusobacterium nucleatum; Oral health; Periodontal diseases |
المشرفين على المادة: | 0 (Antineoplastic Agents) |
تواريخ الأحداث: | Date Created: 20230921 Date Completed: 20231108 Latest Revision: 20240308 |
رمز التحديث: | 20240308 |
DOI: | 10.1007/s00784-023-05270-1 |
PMID: | 37735213 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1436-3771 |
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DOI: | 10.1007/s00784-023-05270-1 |