دورية أكاديمية
أعرض في EDS

Antineoplastic therapy in childhood cancer patients presents a negative impact in the periodontal tissues: a cohort study.

التفاصيل البيبلوغرافية
العنوان: Antineoplastic therapy in childhood cancer patients presents a negative impact in the periodontal tissues: a cohort study.
المؤلفون: Longo BC; Department of Dentistry, State University of Maringá (UEM), Av. Mandacaru, 1550, Campus Universitário, Maringá, Paraná, Brazil., Rohling IB; Department of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, Paraná, Brazil., Silva PLMOE; Department of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, Paraná, Brazil., de Morais MEF; Department of Dentistry, State University of Maringá (UEM), Av. Mandacaru, 1550, Campus Universitário, Maringá, Paraná, Brazil., Paz HES; Department of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil., Casarin RCV; Department of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil., Nishiyama SAB; Department of Basic Health Sciences, State University of Maringá (UEM), Maringá, Paraná, Brazil., de Souza MDB; Department of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, Paraná, Brazil., Silva CO; Department of Dentistry, State University of Maringá (UEM), Av. Mandacaru, 1550, Campus Universitário, Maringá, Paraná, Brazil. prof.cleversonsilva@gmail.com.
المصدر: Clinical oral investigations [Clin Oral Investig] 2023 Nov; Vol. 27 (11), pp. 6637-6644. Date of Electronic Publication: 2023 Sep 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 9707115 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1436-3771 (Electronic) Linking ISSN: 14326981 NLM ISO Abbreviation: Clin Oral Investig
أسماء مطبوعة: Publication: Berlin : Springer-Verlag
Original Publication: Berlin : Springer, c1997-
مواضيع طبية MeSH: Neoplasms*/drug therapy , Periodontitis*/microbiology , Gingivitis*/microbiology , Antineoplastic Agents*/pharmacology, Humans ; Child ; Adolescent ; Cohort Studies ; Periodontal Pocket/microbiology ; Porphyromonas gingivalis ; Fusobacterium nucleatum ; Aggregatibacter actinomycetemcomitans
مستخلص: Objectives: To investigate the effect of antineoplastic therapy (AT) in the periodontal tissues of childhood cancer (CC) patients.
Materials and Methods: Seventy-two individuals were divided into CC (n=36) and healthy individuals (control group-CG, n=36). Demographics, hygiene habits, CC type, and AT were collected. Salivary flow and the presence and concentration of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, and Fusobacterium nucleatum were analyzed. Clinical evaluation included plaque (PI) and gingival indexes (GI), periodontal probing depth (PPD), and clinical attachment level (CAL). Patients were classified into periodontal health, gingivitis, or periodontitis. Descriptive statistics, T test, Mann-Whitney test, chi-square, Fisher's exact test, and two-way analysis of variance were used (p<0.05).
Results: The mean age of the patients was similar (CC 12.0±3.9 years and CG 12.0±4.0 years). In the CC group, all patients underwent chemotherapy and nine radiotherapy. Color/race, income, and family education showed significant differences between groups. There was no difference between groups in salivary flow. Higher levels of Fusobacterium nucleatum were seen in CC (p=0.02). Significant difference between groups was found for PI (CC: 30.5%, CG: 22.6%), GI (CC: 28.8%, CG: 17.3%), PPD (CC: 1.77 mm, CG: 1.61 mm), and CAL (CC: 1.77 mm, CG: 1.57 mm), periodontal health (CC: 3, CG: 7), gingivitis (CC: 16, CG: 24), or periodontitis (CC: 17, CG: 5).
Conclusion: AT in CC patients presents a negative impact in the periodontal and microbiological parameters.
Clinical Relevance: Childhood cancer individuals showed worse periodontal parameters and higher levels of Fusobacterium nucleatum in the saliva when compared to healthy individuals.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
References: International Agency for Research on Cancer - IARC (2016) World health organization: international childhood cancer day: much remains to be done to fight childhood cancer. https://www.iarc.fr/en/media-centre/pr/2016/pdfs/pr241&#95;E.pdf . Accessed 10 January 2023.
Instituto Nacional do Câncer – INCA (2023) Tipos de câncer: câncer infantojuvenil. https://www.inca.gov.br/tipos-de-cancer/cancer-infantojuvenil . Accessed 10 January 2023.
Çetiner D, Çetiner S, Uraz A, Alpaslan GH, Alpaslan C, Toygar Memikoğlu TU, Karadeniz C (2019) Oral and dental alterations and growth disruption following chemotherapy in long-term survivors of childhood malignancies. Support Care Cancer 27:1891–1899. https://doi.org/10.1007/s00520-018-4454-0. (PMID: 10.1007/s00520-018-4454-030203360)
Oeffinger KC, Mertens AC, Sklar CA, Childhood cancer survivor study et al (2006) Chronic health conditions in adult survivors of childhood cancer. N Engl J Med 12:1572–1582. https://doi.org/10.1056/NEJMsa060185. (PMID: 10.1056/NEJMsa060185)
Cubukcu CE, Sevinir B, Ercan I (2012) Disturbed dental development of permanent teeth in children with solid tumors and lymphomas. Pediatr Blood Cancer 58:80–84. https://doi.org/10.1002/pbc.22902. (PMID: 10.1002/pbc.2290221254371)
Alpaslan G, Alpaslan C, Gögen H, Oğuz A, Cetiner S, Karadeniz C (1999) Disturbances in oral and dental structures in patients with pediatric lymphoma after chemotherapy: a preliminary report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87:317–321. https://doi.org/10.1016/s1079-2104(99)70215-5. (PMID: 10.1016/s1079-2104(99)70215-510102592)
Pedersen LB, Clausen N, Schrøder H, Schmidt M, Poulsen S (2012) Microdontia and hypodontia of premolars and permanent molars in childhood cancer survivors after chemotherapy. Int J Paediatr Dent 22:239–243. https://doi.org/10.1111/j.1365-263X.2011.01199.x. (PMID: 10.1111/j.1365-263X.2011.01199.x22092748)
Nemeth O, Hermann P, Kivovics P, Garami M (2013) Long-term effects of chemotherapy on dental status of children cancer survivors. Pediatr Hematol Oncol 30:208–215. https://doi.org/10.3109/08880018.2013.763391. (PMID: 10.3109/08880018.2013.76339123373734)
Avşar A, Elli M, Darka O, Pinarli G (2007) Long-term effects of chemotherapy on caries formation, dental development, and salivary factors in childhood cancer survivors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:781–789. https://doi.org/10.1016/j.tripleo.2007.02.029. (PMID: 10.1016/j.tripleo.2007.02.02917618135)
Valéra MC, Noirrit-Esclassan E, Pasquet M, Vaysse F (2015) Oral complications and dental care in children with acute lymphoblastic leukaemia. J Oral Pathol Med 44:483–489. https://doi.org/10.1111/jop.12266. (PMID: 10.1111/jop.1226625243950)
Morais EF, Lira JA, Macedo RA, Santos KS, Elias CT, Morais Mde L (2014) Oral manifestations resulting from chemotherapy in children with acute lymphoblastic leukemia. Braz J Otorhinolaryngol 80:78–85. https://doi.org/10.5935/1808-8694.20140015. (PMID: 10.5935/1808-8694.20140015246268969443976)
Oğuz A, Cetiner S, Karadeniz C, Alpaslan G, Alpaslan C, Pinarli G (2004) Long-term effects of chemotherapy on orodental structures in children with non-Hodgkin’s lymphoma. Eur J Oral Sci 112:8–11. https://doi.org/10.1111/j.0909-8836.2004.00094.x. (PMID: 10.1111/j.0909-8836.2004.00094.x14871187)
Hegde AM, Joshi S, Rai K, Shetty S (2011) Evaluation of oral hygiene status, salivary characteristics and dental caries experience in acute lymphoblastic leukemic (ALL) children. J Clin Pediatr Dent 35:319–323. https://doi.org/10.17796/jcpd.35.3.u5kx28q33m760834. (PMID: 10.17796/jcpd.35.3.u5kx28q33m76083421678678)
Shayani A, Aravena PC, Rodríguez-Salinas C, Escobar-Silva P, Diocares-Monsálvez Y, Angulo-Gutiérrez C, Rivera C (2022) Chemotherapy as a risk factor for caries and gingivitis in children with acute lymphoblastic leukemia: a retrospective cohort study. Int J Paediatr Dent 32:538–545. https://doi.org/10.1111/ipd.12932. (PMID: 10.1111/ipd.1293234653279)
Soutome S, Otsuru M, Kawashita Y, Funahara M, Ukai T, Saito T (2021) Effect of cancer treatment on the worsening of periodontal disease and dental caries: a preliminary, retrospective study. Oral Health Prev Dent 7:399–404. https://doi.org/10.3290/j.ohpd.b1757253. (PMID: 10.3290/j.ohpd.b1757253)
Papapanou PN, Sanz M, Buduneli N et al (2018) Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions. J Periodontol 89:S173–S182. https://doi.org/10.1002/JPER.17-0721. (PMID: 10.1002/JPER.17-072129926951)
Trombelli L, Farina R, Silva CO, Tatakis DN (2018) Plaque-induced gingivitis: case definition and diagnostic considerations. J Clin Periodontol 45(Suppl 20):S44–S67. https://doi.org/10.1111/jcpe.12939. (PMID: 10.1111/jcpe.1293929926492)
Lang NP, Bartold PM (2018) Periodontal health. J Periodontol 89(Suppl 1):S9–S16. https://doi.org/10.1002/JPER.16-0517. (PMID: 10.1002/JPER.16-051729926938)
Chen Y, Shi T, Li Y, Huang L, Yin D (2022) Fusobacterium nucleatum: the opportunistic pathogen of periodontal and peri-implant diseases. Front Microbiol 13:860149. https://doi.org/10.3389/fmicb.2022.860149. (PMID: 10.3389/fmicb.2022.860149353695228966671)
Araujo MW, Hovey KM, Benedek JR et al (2003) Reproducibility of probing depth measurement using a constant-force electronic probe: analysis of inter- and intraexaminer variability. J Periodontol 74:1736–1740. https://doi.org/10.1902/jop.2003.74.12.1736. (PMID: 10.1902/jop.2003.74.12.173614974813)
Carmo CDS, Ribeiro MRC, Teixeira JXP et al (2018) Added sugar consumption and chronic oral disease burden among adolescents in Brazil. J Dent Res 97:508–514. https://doi.org/10.1177/0022034517745326. (PMID: 10.1177/002203451774532629342369)
Steliarova-Foucher E, Colombet M, Ries LAG, Rous B, Stiller CA (2017) Classification of tumours. In: Steliarova-Foucher E, Colombet M, Ries LAG, Moreno F, Dolya A, Shin HY, Hesseling P, Stiller CA (eds) International incidence of childhood cancer, vol III. International Agency for Research on Cancer, Lyon (In press).  https://seer.cancer.gov/iccc/iccc-iarc-2017.html . Accessed 02 May 2021.
Ericsson Y, Hardwick L (1978) Individual diagnosis, prognosis and counselling for caries prevention. Caries Res 12:94–102. https://doi.org/10.1159/000260369. (PMID: 10.1159/000260369277298)
Falcão DP, de Mota LMH, Pires AL, Bezerra ACB (2013) Sialometria: aspectos de interesse clínico. Rev Bras Reumatol 53:525–531. https://doi.org/10.1016/j.rbr.2013.03.001. (PMID: 10.1016/j.rbr.2013.03.00124477731)
Casarin RC, Peloso Ribeiro ED, Sallum EA, Nociti FH Jr, Gonçalves RB, Casati MZ (2012) The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment. J Periodontol 83:988–998. https://doi.org/10.1902/jop.2012.110513. (PMID: 10.1902/jop.2012.11051322288485)
Ainamo J, Bay I (1975) Problems and proposals for recording gingivitis and plaque. Int Dent J 25:229–235. (PMID: 1058834)
Longo BC, Popiolek IM, Vale NG, ALCA R, MDB S (2021) Epidemiological study of childhood and adolescent cancer in Cascavel cancer hospital UOPECCAN between 2000 and 2014. Rev Bras Cancerol 67:e-201224. https://doi.org/10.32635/2176-9745.RBC.2021v67n3.1224. (PMID: 10.32635/2176-9745.RBC.2021v67n3.1224)
Ward E, DeSantis C, Robbins A, Kohler B, Jemal A (2014) Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin 64:83–103. https://doi.org/10.3322/caac.21219. (PMID: 10.3322/caac.2121924488779)
Da Silva DB, Pires M, Nassar SM (2002) Câncer pediátrico: análise de um registro hospitalar. J Pediatr 78:409–414. https://doi.org/10.1590/S0021-75572002000500012. (PMID: 10.1590/S0021-75572002000500012)
Little J (1999) Epidemiology of childhood cancer. IARC Scientific Publications No. 149, Oxford.
Mataki S (1981) Comparison of the effect of colchicine and vinblastine on the inhibition of dentinogenesis in rat incisors. Arch Oral Biol 26:955–961. https://doi.org/10.1016/0003-9969(81)90103-5. (PMID: 10.1016/0003-9969(81)90103-56951518)
Lyaruu DM, van Duin MA, Bervoets TJM, Wöltgens JHM, Bronckers ALJJ (1997) Effects of actinomycin D on developing hamster molar tooth germs in vitro. Eur J Oral Sci 105:52–58. https://doi.org/10.1111/j.1600-0722.1997.tb00180.x. (PMID: 10.1111/j.1600-0722.1997.tb00180.x9085029)
Jones TE, Henderson JS 3rd, Johnson RB (2005) Effects of doxorubicin on human dental pulp cells in vitro. Cell Biol Toxicol 21:207–214. https://doi.org/10.1007/s10565-005-0165-7. (PMID: 10.1007/s10565-005-0165-716323057)
Sonis AL, Tarbell N, Valachovic RW, Gelber R, Schwenn M, Sallan S (1990) Dentofacial development in long-term survivors of acute lymphoblastic leukemia. A comparison of three treatment modalities. Cancer 15:2645–2652. (PMID: 10.1002/1097-0142(19901215)66:12<2645::AID-CNCR2820661230>3.0.CO;2-S)
Seremidi K, Kloukos D, Polychronopoulou A, Kattamis A, Kavvadia K (2019) Late effects of chemo and radiation treatment on dental structures of childhood cancer survivors. A systematic review and meta-analysis. Head Neck 41:3422–3433. https://doi.org/10.1002/hed.25840. (PMID: 10.1002/hed.2584031228308)
Söder B, Yakob M, Meurman JH, Andersson LC, Söder PÖ (2012) The association of dental plaque with cancer mortality in Sweden. A longitudinal study. BMJ Open 11:e001083. https://doi.org/10.1136/bmjopen-2012-001083. (PMID: 10.1136/bmjopen-2012-001083)
Kinane DF, Stathopoulou PG, Papapanou PN (2017) Periodontal diseases. Nat Rev Dis Primers 22:17038. https://doi.org/10.1038/nrdp.2017.38. (PMID: 10.1038/nrdp.2017.38)
Duggal MS, Curzon ME, Bailey CC, Lewis IJ, Prendergast M (1997) Dental parameters in the long-term survivors of childhood cancer compared with siblings. Oral Oncol 33:348–353. https://doi.org/10.1016/s1368-8375(97)89103-8. (PMID: 10.1016/s1368-8375(97)89103-89415335)
Sonis ST, Elting LS, Keefe D et al (2004) Mucositis study section of the multinational association for supportive care in cancer; international society for oral oncology. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 1:1995–2025. https://doi.org/10.1002/cncr.20162. (PMID: 10.1002/cncr.20162)
Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr (1998) Microbial complexes in subgingival plaque. J Clin Periodontol 25:134–144. https://doi.org/10.1111/j.1600-051x.1998.tb02419.x. (PMID: 10.1111/j.1600-051x.1998.tb02419.x9495612)
Thurnheer T, Karygianni L, Flury M, Belibasakis GN (2019) Fusobacterium species and subspecies differentially affect the composition and architecture of supra- and subgingival biofilms models. Front Microbiol 10:1716. https://doi.org/10.3389/fmicb.2019.01716. (PMID: 10.3389/fmicb.2019.01716314175146683768)
Brennan CA, Garrett WS (2019) Fusobacterium nucleatum - symbiont, opportunist and oncobacterium. Nat Rev Microbiol 17:156–166. https://doi.org/10.1038/s41579-018-0129-6. (PMID: 10.1038/s41579-018-0129-6305461136589823)
Gursoy UK, Könönen E, Uitto VJ (2008) Intracellular replication of fusobacteria requires new actin filament formation of epithelial cells. APMIS 116:1063–1070. https://doi.org/10.1111/j.1600-0463.2008.00868.x. (PMID: 10.1111/j.1600-0463.2008.00868.x19133009)
Gursoy UK, Pöllänen M, Könönen E, Uitto VJ (2010) Biofilm formation enhances the oxygen tolerance and invasiveness of Fusobacterium nucleatum in an oral mucosa culture model. J Periodontol 81:1084–1091. https://doi.org/10.1902/jop.2010.090664. (PMID: 10.1902/jop.2010.09066420350156)
Kostic AD, Gevers D, Pedamallu CS et al (2012) Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res 22:292–298. https://doi.org/10.1101/gr.126573.111. (PMID: 10.1101/gr.126573.111220099903266036)
Mitsuhashi K, Nosho K, Sukawa Y et al (2015) Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis. Oncotarget 30:7209–7220. https://doi.org/10.18632/oncotarget.3109. (PMID: 10.18632/oncotarget.3109)
Yamamura K, Izumi D, Kandimalla R et al (2019) Intratumoral Fusobacterium nucleatum levels predict therapeutic response to neoadjuvant chemotherapy in esophageal squamous cell carcinoma. Clin Cancer Res 15:6170–6179. https://doi.org/10.1158/1078-0432. (PMID: 10.1158/1078-0432)
Parhi L, Alon-Maimon T, Sol A et al (2020) Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression. Nat Commun 26:3259. https://doi.org/10.1038/s41467-020-16967-2. (PMID: 10.1038/s41467-020-16967-2)
Dadashi M, Hajikhani B, Faghihloo E et al (2021) Proliferative effect of fada recombinant protein from Fusobacterium nucleatum on sw480 colorectal cancer cell line. Infect Disord Drug Targets 21:623–628. https://doi.org/10.2174/1871526520666200720113004. (PMID: 10.2174/187152652066620072011300432691717)
Liu Y, Baba Y, Ishimoto T et al (2021) Fusobacterium nucleatum confers chemoresistance by modulating autophagy in oesophageal squamous cell carcinoma. Br J Cancer 124:963–974. https://doi.org/10.1038/s41416-020-01198-5. (PMID: 10.1038/s41416-020-01198-533299132)
فهرسة مساهمة: Keywords: Antineoplastic protocols; Cancer survivors; Fusobacterium nucleatum; Oral health; Periodontal diseases
المشرفين على المادة: 0 (Antineoplastic Agents)
تواريخ الأحداث: Date Created: 20230921 Date Completed: 20231108 Latest Revision: 20240308
رمز التحديث: 20240308
DOI: 10.1007/s00784-023-05270-1
PMID: 37735213
قاعدة البيانات: MEDLINE
الوصف
تدمد:1436-3771
DOI:10.1007/s00784-023-05270-1