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A bioinformatics screen reveals hox and chromatin remodeling factors at the Drosophila histone locus.

التفاصيل البيبلوغرافية
العنوان: A bioinformatics screen reveals hox and chromatin remodeling factors at the Drosophila histone locus.
المؤلفون: Hodkinson LJ; Genetics and Molecular Biology graduate program, Emory University, Atlanta, GA, 30322, USA., Smith C; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Comstra HS; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Ajani BA; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Albanese EH; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Arsalan K; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Daisson AP; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Forrest KB; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Fox EH; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Guerette MR; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Khan S; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Koenig MP; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Lam S; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Lewandowski AS; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Mahoney LJ; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Manai N; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Miglay J; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Miller BA; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Milloway O; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Ngo N; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Ngo VD; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Oey NF; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Punjani TA; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., SiMa H; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Zeng H; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA., Schmidt CA; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA. casey.schmidt@emory.edu., Rieder LE; Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, 30322, USA. leila.rieder@emory.edu.
المصدر: BMC genomic data [BMC Genom Data] 2023 Sep 21; Vol. 24 (1), pp. 54. Date of Electronic Publication: 2023 Sep 21.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101775394 Publication Model: Electronic Cited Medium: Internet ISSN: 2730-6844 (Electronic) Linking ISSN: 27306844 NLM ISO Abbreviation: BMC Genom Data Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2021]-
مواضيع طبية MeSH: Drosophila Proteins*/genetics , Infertility*, Female ; Animals ; Drosophila ; Drosophila melanogaster/genetics ; Histones/genetics ; Chromatin Assembly and Disassembly/genetics ; Computational Biology ; Transcription Factors/genetics ; Homeodomain Proteins/genetics ; Protein Serine-Threonine Kinases
مستخلص: Background: Cells orchestrate histone biogenesis with strict temporal and quantitative control. To efficiently regulate histone biogenesis, the repetitive Drosophila melanogaster replication-dependent histone genes are arrayed and clustered at a single locus. Regulatory factors concentrate in a nuclear body known as the histone locus body (HLB), which forms around the locus. Historically, HLB factors are largely discovered by chance, and few are known to interact directly with DNA. It is therefore unclear how the histone genes are specifically targeted for unique and coordinated regulation.
Results: To expand the list of known HLB factors, we performed a candidate-based screen by mapping 30 publicly available ChIP datasets of 27 unique factors to the Drosophila histone gene array. We identified novel transcription factor candidates, including the Drosophila Hox proteins Ultrabithorax (Ubx), Abdominal-A (Abd-A), and Abdominal-B (Abd-B), suggesting a new pathway for these factors in influencing body plan morphogenesis. Additionally, we identified six other factors that target the histone gene array: JIL-1, hormone-like receptor 78 (Hr78), the long isoform of female sterile homeotic (1) (fs(1)h) as well as the general transcription factors TBP associated factor 1 (TAF-1), Transcription Factor IIB (TFIIB), and Transcription Factor IIF (TFIIF).
Conclusions: Our foundational screen provides several candidates for future studies into factors that may influence histone biogenesis. Further, our study emphasizes the powerful reservoir of publicly available datasets, which can be mined as a primary screening technique.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
التعليقات: Update of: bioRxiv. 2023 Jan 06;:. (PMID: 36711759)
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معلومات مُعتمدة: R35 GM142724 United States GM NIGMS NIH HHS; K12 GM000680 United States GM NIGMS NIH HHS; T32 GM008490 United States GM NIGMS NIH HHS; R00 HD092625 United States HD NICHD NIH HHS; F32 GM140778 United States GM NIGMS NIH HHS; F31 HD105452 United States HD NICHD NIH HHS
فهرسة مساهمة: Keywords: ChIP-seq; Course-based Undergraduate Research Experience; Drosophila; Galaxy; Histone locus; Histone locus body; Hox factors
المشرفين على المادة: 0 (Histones)
0 (Drosophila Proteins)
0 (Ubx protein, Drosophila)
0 (Transcription Factors)
0 (Homeodomain Proteins)
EC 2.7.11.1 (JIL-1 protein, Drosophila)
EC 2.7.11.1 (Protein Serine-Threonine Kinases)
تواريخ الأحداث: Date Created: 20230922 Date Completed: 20230925 Latest Revision: 20240423
رمز التحديث: 20240423
مُعرف محوري في PubMed: PMC10515271
DOI: 10.1186/s12863-023-01147-0
PMID: 37735352
قاعدة البيانات: MEDLINE
الوصف
تدمد:2730-6844
DOI:10.1186/s12863-023-01147-0