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Initial experience with an electron FLASH research extension (FLEX) for the Clinac system.

التفاصيل البيبلوغرافية
العنوان: Initial experience with an electron FLASH research extension (FLEX) for the Clinac system.
المؤلفون: Oh K; University of Nebraska Medical Center, Omaha, Nebraska, USA., Gallagher KJ; University of Nebraska Medical Center, Omaha, Nebraska, USA., Hyun M; University of Nebraska Medical Center, Omaha, Nebraska, USA., Schott D; University of Nebraska Medical Center, Omaha, Nebraska, USA., Wisnoskie S; University of Nebraska Medical Center, Omaha, Nebraska, USA., Lei Y; University of Nebraska Medical Center, Omaha, Nebraska, USA., Hendley S; University of Nebraska Medical Center, Omaha, Nebraska, USA., Wong J; University of Nebraska Medical Center, Omaha, Nebraska, USA., Wang S; University of Nebraska Medical Center, Omaha, Nebraska, USA., Graff B; University of Nebraska Medical Center, Omaha, Nebraska, USA., Jenkins C; University of Nebraska Medical Center, Omaha, Nebraska, USA., Rutar F; University of Nebraska Medical Center, Omaha, Nebraska, USA., Ahmed M; Varian Medical Systems, Palo Alto, California, USA., McNeur J; Varian Medical Systems, Palo Alto, California, USA., Taylor J; Varian Medical Systems, Palo Alto, California, USA., Schmidt M; Varian Medical Systems, Palo Alto, California, USA., Senadheera L; Varian Medical Systems, Palo Alto, California, USA., Smith W; Varian Medical Systems, Palo Alto, California, USA., Umstadter D; University of Nebraska, Lincoln, Nebraska, USA., Lele SM; University of Nebraska Medical Center, Omaha, Nebraska, USA., Dai R; University of Nebraska Medical Center, Omaha, Nebraska, USA., Jianghu James D; University of Nebraska Medical Center, Omaha, Nebraska, USA., Yan Y; University of Nebraska Medical Center, Omaha, Nebraska, USA., Su-Min Z; University of Nebraska Medical Center, Omaha, Nebraska, USA.
المصدر: Journal of applied clinical medical physics [J Appl Clin Med Phys] 2024 Feb; Vol. 25 (2), pp. e14159. Date of Electronic Publication: 2023 Sep 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley on behalf of American Association of Physicists in Medicine Country of Publication: United States NLM ID: 101089176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-9914 (Electronic) Linking ISSN: 15269914 NLM ISO Abbreviation: J Appl Clin Med Phys Subsets: MEDLINE
أسماء مطبوعة: Publication: 2017- : Malden, MA : Wiley on behalf of American Association of Physicists in Medicine
Original Publication: Reston, VA : American College of Medical Physics, c2000-
مواضيع طبية MeSH: Electrons* , Radiometry*, Humans ; Radiotherapy Dosage ; Particle Accelerators ; Radiation Dosimeters
مستخلص: Purpose: Radiotherapy delivered at ultra-high-dose-rates (≥40 Gy/s), that is, FLASH, has the potential to effectively widen the therapeutic window and considerably improve the care of cancer patients. The underlying mechanism of the FLASH effect is not well understood, and commercial systems capable of delivering such dose rates are scarce. The purpose of this study was to perform the initial acceptance and commissioning tests of an electron FLASH research product for preclinical studies.
Methods: A linear accelerator (Clinac 23EX) was modified to include a non-clinical FLASH research extension (the Clinac-FLEX system) by Varian, a Siemens Healthineers company (Palo Alto, CA) capable of delivering a 16 MeV electron beam with FLASH and conventional dose rates. The acceptance, commissioning, and dosimetric characterization of the FLEX system was performed using radiochromic film, optically stimulated luminescent dosimeters, and a plane-parallel ionization chamber. A radiation survey was conducted for which the shielding of the pre-existing vault was deemed sufficient.
Results: The Clinac-FLEX system is capable of delivering a 16 MeV electron FLASH beam of approximately 1 Gy/pulse at isocenter and reached a maximum dose rate >3.8 Gy/pulse near the upper accessory mount on the linac gantry. The percent depth dose curves of the 16 MeV FLASH and conventional modes for the 10 × 10 cm 2 applicator agreed within 0.5 mm at a range of 50% of the maximum dose. Their respective profiles agreed well in terms of flatness but deviated for field sizes >10 × 10 cm 2 . The output stability of the FLASH system exhibited a dose deviation of <1%. Preliminary cell studies showed that the FLASH dose rate (180 Gy/s) had much less impact on the cell morphology of 76N breast normal cells compared to the non-FLASH dose rate (18 Gy/s), which induced large-size cells.
Conclusion: Our studies characterized the non-clinical Clinac-FLEX system as a viable solution to conduct FLASH research that could substantially increase access to ultra-high-dose-rate capabilities for scientists.
(© 2023 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.)
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معلومات مُعتمدة: U54 GM115458 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: FLASH Research Extension (FLEX); cell viability; conventional dose rate (CONV); dosimetry; electron Ultra-high dose rate (eFLASH); linear accelerator; stress-activated senescence
تواريخ الأحداث: Date Created: 20230922 Date Completed: 20240214 Latest Revision: 20240228
رمز التحديث: 20240228
مُعرف محوري في PubMed: PMC10860433
DOI: 10.1002/acm2.14159
PMID: 37735808
قاعدة البيانات: MEDLINE
الوصف
تدمد:1526-9914
DOI:10.1002/acm2.14159