دورية أكاديمية
Determination of urinary deanol-N-oxide excretion profiles after ingestion of nutritional supplements containing deanol.
العنوان: | Determination of urinary deanol-N-oxide excretion profiles after ingestion of nutritional supplements containing deanol. |
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المؤلفون: | Krug O; Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Cologne, Germany.; European Monitoring Center for Emerging Doping Agents (EuMoCEDA), Cologne/Bonn, Germany., Guddat S; Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Cologne, Germany., Görgens C; Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Cologne, Germany., Piper T; Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Cologne, Germany., Möller T; Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Cologne, Germany., Thevis M; Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Cologne, Germany.; European Monitoring Center for Emerging Doping Agents (EuMoCEDA), Cologne/Bonn, Germany. |
المصدر: | Drug testing and analysis [Drug Test Anal] 2023 Nov-Dec; Vol. 15 (11-12), pp. 1312-1318. Date of Electronic Publication: 2023 Sep 21. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: England NLM ID: 101483449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-7611 (Electronic) Linking ISSN: 19427603 NLM ISO Abbreviation: Drug Test Anal Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Chichester, UK : John Wiley & Sons |
مواضيع طبية MeSH: | Deanol* , Doping in Sports*, Humans ; Male ; Female ; Meclofenoxate ; Mass Spectrometry ; Eating ; Substance Abuse Detection/methods |
مستخلص: | 2-(Dimethylamino)ethan-1-ol (Deanol) is a widely produced chemical used by both industry and consumers in a variety of applications. Meclofenoxate, a stimulant classified on the World Anti-Doping Agency Prohibited List, metabolizes into deanol and, presumably, its main metabolite deanol-N-oxide. Hence, using liquid chromatography-tandem mass spectrometry, a quantitative detection method for deanol-N-oxide in urine was developed. Subsequently, the urinary excretion of deanol-N-oxide after oral application of 130 mg of deanol was determined in six volunteers, and urine samples of a cohort of 180 male and female athletes from different sports were analyzed. In addition, urinary deanol-N-oxide was determined in an exploratory study with one volunteer ingesting 250 mg of meclofenoxate. The developed test method allowed for limits of detection and quantification for deanol-N-oxide at 0.05 and 0.15 μg/mL, respectively. Urinary deanol-N-oxide c (© 2023 The Authors. Drug Testing and Analysis published by John Wiley & Sons Ltd.) |
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معلومات مُعتمدة: | Federal Ministry of the Interior and Community (Berlin, Germany); Manfred Donike Institute for Doping Analysis e.V. |
فهرسة مساهمة: | Keywords: DMAE; LC-MS; deanol; deanol-N-oxide; doping |
المشرفين على المادة: | 2N6K9DRA24 (Deanol) C76QQ2I0RG (Meclofenoxate) |
تواريخ الأحداث: | Date Created: 20230922 Date Completed: 20231204 Latest Revision: 20231204 |
رمز التحديث: | 20231215 |
DOI: | 10.1002/dta.3580 |
PMID: | 37735938 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1942-7611 |
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DOI: | 10.1002/dta.3580 |