دورية أكاديمية
Determination of urinary deanol-N-oxide excretion profiles after ingestion of nutritional supplements containing deanol.
| العنوان: | Determination of urinary deanol-N-oxide excretion profiles after ingestion of nutritional supplements containing deanol. |
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| المؤلفون: | Krug O; Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Cologne, Germany.; European Monitoring Center for Emerging Doping Agents (EuMoCEDA), Cologne/Bonn, Germany., Guddat S; Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Cologne, Germany., Görgens C; Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Cologne, Germany., Piper T; Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Cologne, Germany., Möller T; Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Cologne, Germany., Thevis M; Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Cologne, Germany.; European Monitoring Center for Emerging Doping Agents (EuMoCEDA), Cologne/Bonn, Germany. |
| المصدر: | Drug testing and analysis [Drug Test Anal] 2023 Nov-Dec; Vol. 15 (11-12), pp. 1312-1318. Date of Electronic Publication: 2023 Sep 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: England NLM ID: 101483449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-7611 (Electronic) Linking ISSN: 19427603 NLM ISO Abbreviation: Drug Test Anal Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Chichester, UK : John Wiley & Sons |
| مواضيع طبية MeSH: | Deanol* , Doping in Sports*, Humans ; Male ; Female ; Meclofenoxate ; Mass Spectrometry ; Eating ; Substance Abuse Detection/methods |
| مستخلص: | 2-(Dimethylamino)ethan-1-ol (Deanol) is a widely produced chemical used by both industry and consumers in a variety of applications. Meclofenoxate, a stimulant classified on the World Anti-Doping Agency Prohibited List, metabolizes into deanol and, presumably, its main metabolite deanol-N-oxide. Hence, using liquid chromatography-tandem mass spectrometry, a quantitative detection method for deanol-N-oxide in urine was developed. Subsequently, the urinary excretion of deanol-N-oxide after oral application of 130 mg of deanol was determined in six volunteers, and urine samples of a cohort of 180 male and female athletes from different sports were analyzed. In addition, urinary deanol-N-oxide was determined in an exploratory study with one volunteer ingesting 250 mg of meclofenoxate. The developed test method allowed for limits of detection and quantification for deanol-N-oxide at 0.05 and 0.15 μg/mL, respectively. Urinary deanol-N-oxide c (© 2023 The Authors. Drug Testing and Analysis published by John Wiley & Sons Ltd.) |
| References: | Shipkowski KA, Sanders JM, McDonald JD, et al. Comparative disposition of dimethylaminoethanol and choline in rats and mice following oral or intravenous administration. Toxicol Appl Pharmacol. 2019;378:114592. doi:10.1016/j.taap.2019.05.011. Pfeiffer CC, Denny EH, Gallagher W, et al. Stimulant effects of 2-dimethylaminoethanol-possible precursor of brain acetylcholine. Science. 1957;126:610-611. doi:10.1126/science.126.3274.610. Casey DE, Denny D. Pharmacological characterization of tardive dyskinesia. Psychopharmacology (Berl). 1977;54(1):1-8. doi:10.1007/BF00426532. Simpson GM, Voitashevsky A, Young MA, Lee JH. Deanol in the treatment of tardive dyskinesia. Psychopharmacology (Berl). 1977;52(3):257-261. doi:10.1007/BF00426709. De Silva L. Biochemical mechanisms and management of choreiform movement disorders. Drugs. 1977;14(4):300-310. doi:10.2165/00003495-197714040-00005. Malanga G, Aguiar MB, Martinez HD, Puntarulo S. New insights on dimethylaminoethanol (DMAE) features as a free radical scavenger. Drug Metab Lett. 2012;6(1):54-59. doi:10.2174/187231212800229282. Dormard Y, Levron JC, Le Fur JM. Pharmacokinetic study of maleate acid of 2-(N,N-dimethylaminoethanol-14C1)-cyclohexylpropionate (cyprodenate) and of N,N-dimethylaminoethanol-14C1 in animals. Arzneimittelforschung. 1975;25(2):201-207. Rubio A, Görgens C, Krug O, et al. Chromatographic-mass spectrometric analysis of the urinary metabolite profile of chlorphenesin observed after dermal application of chlorphenesin-containing sunscreen. Rapid Commun Mass Spectrom. 2021;35(21):e9183. doi:10.1002/rcm.9183. World Anti-Doping Agency (WADA). Accessed August 15, 2023. https://www.wada-ama.org/sites/default/files/resources/files/WADA_Prohibited_List_2006_EN.pdf. Cymerman Craiq J, Purushothaman KK. An improved preparation of tertiary amine N-oxides. J Org Chem. 1970;35(5):1721-1722. doi:10.1021/jo00830a121. Beckett AH, Coutts RT, OGunbona FA. Synthesis of N-alkyl-N-hydroxyamphetamines and related nitrones. Tetrahedron. 1973;29(24):4189-4193. doi:10.1016/0040-4020(73)80256-X. Honegger CG, Honegger R. Occurrence and quantitative determination of 2-dimethylaminoethanol in animal tissue extracts. Nature. 1959;184(4685):550-552. doi:10.1038/184550a0. |
| معلومات مُعتمدة: | Federal Ministry of the Interior and Community (Berlin, Germany); Manfred Donike Institute for Doping Analysis e.V. |
| فهرسة مساهمة: | Keywords: DMAE; LC-MS; deanol; deanol-N-oxide; doping |
| المشرفين على المادة: | 2N6K9DRA24 (Deanol) C76QQ2I0RG (Meclofenoxate) |
| تواريخ الأحداث: | Date Created: 20230922 Date Completed: 20231204 Latest Revision: 20231204 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/dta.3580 |
| PMID: | 37735938 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1942-7611 |
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| DOI: | 10.1002/dta.3580 |